E X T O X N E T
Extension Toxicology Network
A Pesticide Information Project of Cooperative Extension Offices of
Cornell University, Michigan State University, Oregon State University, and
University of California at Davis. Major support and funding was provided
by the USDA/Extension Service/National Agricultural Pesticide Impact
Assessment Program.
| |
Pesticide
Information
Profile
|
Dodine
Publication Date: 9/93
|
|
TRADE AND OTHER NAMES
Other common names include dodine acetate, doguadine (France), and
tsitrex (USSR). Trade names include AC 5223, Apadodine, Carpene, Curitan,
Cyprex, Efuzin, Melprex, Sulgen, Syllit, Tebulan, Vandodine and Venturol.
REGULATORY STATUS
Products containing dodine must bear the signal word "Danger" on the
label (1).
INTRODUCTION
Dodine is a fungicide used to control scab on apples, pears and pecans,
brown rot of peaches, and several foliar diseases of cherries, strawberries,
peaches, sycamore trees and black walnuts (1). It is also used as an
industrial biocide and preservative (3). It is available as soluble
concentrate and wettable powder formulations (1).
TOXICOLOGICAL EFFECTS
ACUTE TOXICITY
Because it may cause severe eye irritation, dodine is considered a highly
toxic material (1). Dodine is not acutely toxic via inhalation or ingestion
(3).
The oral LD50 for technical dodine in rats is 1,000 mg/kg (1, 4). The
dermal LD50 on rats is > 6,000 mg/kg, and on rabbits is > 1,500 mg/kg for a
single 24-hour contact (1). Dodine did not cause allergic skin reactions
when tested on humans. It is an eye and skin irritant (3).
CHRONIC TOXICITY
Chronic dietary exposure in rats caused reduced weight gain in both sexes
and reduced food consumption in males. The NOEL in this study was 10 mg/kg
(3). Dogs fed dodine for 12 months exhibited histological changes in the
thyroid indicative of thyroid stimulation. The NOEL in this study was 50 ppm
(1.25 mg/kg) (3).
Reproductive Effects
In a 2 year feeding study, rats given dietary doses of 800 mg/kg
exhibited slight retardation of growth, but no adverse effects on reproduction
or lactation (4). Offspring of mice fed dodine in the diet exhibited
decreased numbers of pups surviving to weaning (3).
Teratogenic Effects
No information was found.
Mutagenic Effects
The Ames test for mutagenicity was negative on 5 strains of bacteria (3).
Carcinogenic Effects
No information was found.
Organ Toxicity
No information was found.
Fate in Humans and Animals
No information was found.
ECOLOGICAL EFFECTS
Effects on Birds
The oral LD50 for dodine in mallard ducks is 1,142 mg/kg (4).
Effects on Aquatic Organisms
Dodine is toxic to fish (1). The 48-hour LC50 for dodine in harlequin
fish is 0.53 mg/l (4).
Effects on Other Animals (Nontarget species)
Dodine is non-toxic to bees (1). Its LD50 in honeybees is > 11 mg/bee
for topical application (4).
ENVIRONMENTAL FATE
Breakdown of Chemical in Soil and Groundwater
Dodine may have a large potential to leach and contaminate groundwater.
Its soil half-life is 10 days (2).
Breakdown of Chemical in Surface Water
No information was found.
Breakdown of Chemical in Vegetation
No information was found.
PHYSICAL PROPERTIES AND GUIDELINES
Dodine is a colorless or white, slightly waxy crystalline solid (1, 3).
It is not compatible with lime or chlorobenzilate (1).
Workers handling dodine should wear goggles and protective clothing that
will prevent prolonged skin contact with this material.
Exposure Guidelines:
| PADI: | 0.0013 mg/kg/day based on NOEL of 1.25 mg/kg in a 12 month dog studyand a 1000 fold safety factor (3). |
| MPI: | 0.078 mg/day (3) |
Physical Properties:
| CAS #: | 2439-10-3 |
| Chemical name: | 1-dodecylguanidinium acetate |
| Chemical Class/Use: | aliphatic and alicyclic fungicide |
| H20 solubility: | 63 mg/l at 25 degrees C (4). |
| Solubility in other solvents: | soluble in methanol and ethanol; practically insoluble in most organic solvents (1). |
| Melting point: | 136 degrees C (4) |
| Vapor pressure: | < 10-7, negligible (2) |
| Koc: | 100,000 (2) |
BASIC MANUFACTURER
Rhone Poulenc Ag Co.
PO Box 12014
2 T.W. Alexander Dr.
Research Triangle Park, NC 27609
Telephone: 919-549-2000
Review by Basic Manufacturer:
Comments solicited: April, 1993
Comments received: May, 1993
REFERENCES
Meister, R.T. (ed.). 1992. Farm Chemicals Handbook '92. Meister
Publishing Company, Willoughby, OH.
U. S. Department of Agriculture, Soil Conservation Service. 1990
(Nov.). SCS/ARS/CES Pesticide Properties Database: Version 2.0
(Summary). USDA - Soil Conservation Service, Syracuse, NY.
U.S. Environmental Protection Agency. Feb. 2, 1987. Pesticide Fact
Sheet Number 135: Dodine. US EPA, Office of Pesticide Programs,
Registration Div., Washington, DC.
British Crop Protection Council. 1983. The Pesticide Manual: A World
Compendium, 7th ed. Croydon, England.
Disclaimer: Please read
the pesticide label prior to use. The information contained at this web
site is not a substitute for a pesticide label. Trade names used herein
are for convenience only; no endorsement of products is intended, nor is
criticism of unnamed products implied. Most of this information is historical
in nature and may no longer be applicable.
To Top
For more information relative to pesticides and their use in New York State, please contact the PMEP staff at:
| |
5123 Comstock Hall
Cornell University
Ithaca, NY 14853-0901
(607) 255-1866
|
PLEASE NOTE: If you are not in New York State, you must contact the appropriate
agency for your area.
|
 |
This site is supported, in part, by funding from the
 |
Questions regarding the development of this web site should be directed to the
PMEP Webmaster
