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Validamycin

Publication Date: 9/95

TRADE OR OTHER NAMES

Validamycin is also called Validamycin A. Trade names include Validacin, Valimon; and Solacol (1, 2, 3).

REGULATORY STATUS

Validamycin is not registered for sale or use in the U.S. (2).

INTRODUCTION

Validamycin is a non-systemic antibiotic with fungicide action. It is produced from fermentation of streptomyces hygroscopicus variety limoneus (1, 2). It is most effective against soil borne diseases and is used for the control of Rhizoctonia solani in rice, potatoes, vegetables, and others as well as damping off diseases in vegetable seedlings, cotton, sugar beets, rice and other plants (2, 3, 4).The U.S. EPA has classified validamycin as Toxicity Class IV- practically non-toxic. For products containing validamycin, bearing a Signal Word is not required (3). Validamycin is found as a soluble concentrate, a dustable powder, and a seed treatment (4).

TOXICOLOGICAL EFFECTS

ACUTE TOXICITY

Validamycin is practically non-toxic. The dose which kills half of the test animals, the LD50, is 20,000 mg/kg for rats and 2,000 mg/kg in mice (4). For skin exposure, the LD50 is greater than 5 gm/kg in rats. It is non- irritating to skin when tested on rabbits (2).

CHRONIC TOXICITY

Reproductive Effects

No information currently available.

Teratogenic Effects

No information currently available.

Mutagenic Effects

Spot tests and other studies of potential affects to DNA of Bacillus subtilis indicate that validamycin is not mutagenic (5).

Carcinogenic Effects

No information currently available.

Organ Toxicity

No information currently available.

Fate in Humans and Animals

No information currently available.

ECOLOGICAL EFFECTS

Effects on Birds

No data are currently available.

Effects on Aquatic Organisms

Validamycin is relatively non-toxic to fish. The LC50 (96 hrs) for carp is 10 mg/l (3).

Effects on Other Animals (Nontarget species)

Validamycin is not toxic to bees (3).

ENVIRONMENTAL FATE

Breakdown of Chemical in Soil and Groundwater

Validamycin undergoes rapid microbial degradation in soil. The half-life is less than 5 hours (3).

Breakdown of Chemical in Water

No information currently available.

Breakdown of Chemical in Vegetation

No information currently available.

PHYSICAL PROPERTIES AND GUIDELINES

Validamycin is a colorless, odorless hygroscopic powder. It is stable at room temperature in neutral or alkaline media. It is slightly unstable in acidic media. Validamycin is non-corrosive.

Physical Properties:

Chemical Name: 1,5,6-Trideoxy-3-O-B-D-Glucopyranosyl-5-hydroxymethyl-1-((4,5,6-Trihydroxy-3-Hydroxymethyl)-2-cyclohexen-1-yl)amino)D-chiro-Inositol
CAS#: 37248-47-8
Melting point: 130-135 degrees C
Solubility in water: Readily soluble in water.
Solubility in other solvents: Soluble in methanol, dimethylformamide, and dimethyl sulfoxide. Slightly soluble in ethanol and acetone

Exposure Guidelines:

NOEL: 40.4 mg/kg/day (rats)(3)

BASIC MANUFACTURER

Takeda Chemical Industries Ltd.
12-10 Nihonbashi 2-Chome
Chuo-ku Tokyo 103 Japan
Telephone: 81-3-3278-2567

Review by Basic Manufacturer:

Comments solicited: October, 1994
Comments received:

REFERENCES

  1. Meister, R.T. 1994. Farm Chemicals Handbook '94. Meister Publishing Company. Willoughby, OH.
  2. Thomson, W. T. 1982. Agricultural Chemicals Book IV Fungicides. Thomson Publications. Fresno, CA.
  3. The Agrochemicals Handbook, Third Edition. 1994. Royal Society of Chemistry Information Systems, Unwin Brothers Ltd., Surrey, England.
  4. National Institute for Occupational Safety and Health (NIOSH). 1993. Registry of Toxic Effects of Chemical Substances (RTECS). NIOSH. Cincinnati, OH.
  5. U.S. Environmental Protection Agency. 1994. GENE-TOX in Toxicology Data Network. U.S. Dept. Health and Human Services. Bethesda, MD.