1,2-dibromo-3-chloropropane - Chemical Profile 6/84
CHEMICAL NAME: 1,2-Dibromo-3-chloropropane (principal constituent)
TRADE NAME(S): DBCP, Nematocide (56)
FORMULATION(S): Emulsifiable and non-emulsifiable concentrates.
Available are Nematocide Solution 17.1,
Nematocide Solution 12.1, Nematocide EM 15.1 and
Nematocide EM 12.1 (56).
TYPE: Soil fumigant-nematicide
BASIC PRODUCER(S): Amvac Chemical Corp.
4100 E. Washington Blvd.
Los Angeles, CA 90023
STATUS: Restricted use. RPAR issued 9/22/77; criteria
possibly met or exceeded: oncogenicity,
reproductive effects. Suspension Order (affecting
all uses except pineapple) and Notice of Intent to
Cancel all uses published 10/29/79. Agreement
reached with registants that all uses, except on
pineapples are cancelled (22).
PRINCIPAL USES: In the U.S. for use on pineapples only (56).
Preplant and postplant fumigant for control of
nematodes on certain crops tolerant to DBCP (48).
To be developed.
II. PHYSICAL PROPERTIES
MOLECULAR FORMULA: C3 H5 Br2 Cl (26)
MOLECULAR WEIGHT: 236.3 (26)
PHYSICAL STATE: Amber to dark brown liquid (pure compound) (26)
ODOR: Mildly pungent odor (pure compound) (26)
BOILING POINT: 196 C (pure compound) (26)
VAPOR PRESSURE: 0.8 mmHg at 21 C (pure compound) (26)
SOLUBILITY: 1 g/kg water at room temperature (pure compound)
III. HEALTH HAZARD INFORMATION
OSHA STANDARD: 1 ug/m3 in manufacturing plants (26)
NIOSH RECOMMENDED LIMIT: NA
ACGIH RECOMMENDED LIMIT: NA
A. ACUTE TOXICITY
DERMAL: LD50 = 1420 mg/kg (rabbit) (26)
ORAL: LD50 = 170-300 mg/kg (rat); 260-400 mg/kg (mouse)
INHALATION: Acute vapor toxicity, 103 ppm (8-hour exposure),
369 ppm (1-hour exposure) (56).
EYES: Not markedly irritant to the eyes (26)
B. SUB-CHRONIC AND CHRONIC TOXICITY:
In 90-day feeding trials the lowest dose level causing a decrease
in growth rate was: for female rats 150 mg/kg, for male rats 450
mg/kg. In lifetime studies in rats and mice it has been shown by the
oral gavage to be carcinogenic (26).
Overexposure can cause reduced sperm count in human males (56).
IV. ENVIRONMENTAL CONSIDERATIONS
Not harmful to beneficial soil microorganisms. Nonhazardous to
honey bees (48).
The LC50 (48 hr) is: for bass 30-50 mg/l; for sunfish 50-125 mg/l
Many perennial plants tolerate high concentrations but others,
including potatoes and tobacco, require a long aeration period before
planting. It does not persist in soil to the extent that creates an
accumulation problem (26).
V. EMERGENCY AND FIRST AID PROCEDURES
The chemical information provided below has been condensed
from original source documents, primarily from "Recognition and
Management of Pesticide Poisonings", 3rd ed. by Donald P. Morgan,
which have been footnoted. This information has been provided in
this form for your convenience and general guidance only. In
specific cases, further consultation and reference may be required
and is recommended. This information is not intended as a sub-
stitute for a more exhaustive review of the literature nor for the
judgement of a physician or other trained professional.
If poisoning is suspected, do not wait for symptoms to develop.
Contact a physician, the nearest hospital, or the nearest Poison
Frequent Symptoms and Signs of Poisoning
headACHE, DIZZINESS, NAUSEA, and vomiting are prominent early
symptoms of excessive exposure to these gases (including
DROWSINESS, TREMORS, double vision, and weakness are the common
early manifestations of central nervous system impairment. Tremors may
progress to myoclonic movements, then to generalized SEIZURES,
UNCONSCIOUSNESS, and death.
Injuries to the skin by liquid fumigants may be manifest as areas of
redness or as BLISTERS which rupture, leaving raw skin or deep ulcers.
If ingested, the LIQUID forms of HALOCARBONS often cause pulmonary
edema and SHOCK within a few moments. If victim survives, injuries to
the brain, liver and kidney are life-threatening.
Longer-term low level inhalation of CHLOROCARBONS may cause liver
damage, first manifest as ANOREXIA, then as JAUNDICE. Biochemical
studies confirm hepatocellular injury (25).
SKIN CONTACT: In case of contact immediately remove contaminated
shoes and clothing and wash with soap and water (56).
INGESTION: If swallowed, drink 1 or 2 glasses of water and
induce vomiting by touching back of throat with finger, or blunt
object. Do not induce vomiting or give anything by mouth to an
unconscious person. Get medical attention (56).
INHALATION: If illness results from inhalation, remove to fresh
air and call a doctor (56).
EYE CONTACT: Flush eyes with plenty of water and get medical
NOTES TO PHYSICIAN:
VI. FIRE AND EXPLOSION INFORMATION
To be developed.
Compatible with other soil fumigants, insecticides and dry
fertilizers. May be corrosive to aluminum and magnesium (48).
VIII. PROTECTIVE MEASURES
STORAGE AND HANDLING: Harmful liquid and vapor. May be fatal if
swallowed, inhaled or absorbed through skin. May cause functional
infertility. Combustible mixture causes skin irritation and blisters
upon prolonged contact. Causes irritation of eyes, nose, throat. May
be absorbed through skin. Do not allow material to remain on skin. If
clothing or shoes become contaminated remove them promptly and do not
wear again until completely free of material (56).
PROTECTIVE CLOTHING: Wear impermeable fullbody clothing except drivers
of surface soil injection equipment who are only required to wear
impermeable protective fullbody clothing during mixing, loading and
transferring operations, and during the calibration of and performance
of maintenance upon the soil injection equipment to avoid any skin or
eye contact (56).
PROTECTIVE EQUIPMENT: Wear a respirator jointly approved by the Mining
Enforcement and Safety Administration and National Institute of
Occupational Safety and Health (56).
IX. PROCEDURES FOR SPILLS AND LEAKS
IN CASE OF EMERGENCY, CALL, DAY OR NIGHT
PESTICIDE TEAM SAFETY NETWORK/CHEMTREC
X. LITERATURE CITED
22. U.S. Environmental Protection Agency, Office of Pesticide
Programs. 1983. June 1983 status report on rebuttable
presumption against registration (RPAR) or special review
process, registration standards and the data call in
programs. Washington, DC. 45 pp.
25. Morgan, D.P. 1982. Recognition and management of
pesticide poisonings, 3rd ed. U. S. Environmental Protection
Agency, Washington, DC. 120 pp.
26. The Pesticide Manual: A World Compendium, 6th ed. 1979. C. R.
Worthing, ed. The British Crop Protection Council, Croydon,
England. 655 pp.
48. Harding, W.C. 1979-80. Pesticide profiles, part two: fungicides
and nematicides. Univ. Maryland, Coop. Ext. Service Bull.
283, 22 pp.
56. Farm Chemicals Handbook, 70th ed. 1984. R. T. Meister, G. L.
Berg, C. Sine, S. Meister, and J. Poplyk, eds. Meister
Publishing Co., Willoughby, OH.