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1,2-dibromo-3-chloropropane - Chemical Profile 6/84


      CHEMICAL NAME:      1,2-Dibromo-3-chloropropane (principal constituent)

      TRADE NAME(S):      DBCP, Nematocide (56)

      FORMULATION(S):     Emulsifiable and non-emulsifiable concentrates.
                          Available are Nematocide Solution 17.1,
                          Nematocide Solution 12.1, Nematocide EM 15.1 and
                          Nematocide EM 12.1 (56).

      TYPE:               Soil fumigant-nematicide

      BASIC PRODUCER(S):  Amvac Chemical Corp.
                          4100 E. Washington Blvd.
                          Los Angeles, CA 90023

      STATUS:             Restricted use.  RPAR issued 9/22/77; criteria
                          possibly met or exceeded:  oncogenicity,
                          reproductive effects.  Suspension Order (affecting
                          all uses except pineapple) and Notice of Intent to
                          Cancel all uses published 10/29/79.  Agreement
                          reached with registants that all uses, except on
                          pineapples are cancelled (22).

      PRINCIPAL USES:     In the U.S. for use on pineapples only (56).
                          Preplant and postplant fumigant for control of
                          nematodes on certain crops tolerant to DBCP (48).

                                   I.  EFFICACY

           To be developed.

                             II.  PHYSICAL PROPERTIES

      MOLECULAR FORMULA:  C3 H5 Br2 Cl (26)

      MOLECULAR WEIGHT:   236.3 (26)

      PHYSICAL STATE:     Amber to dark brown liquid (pure compound) (26)

      ODOR:               Mildly pungent odor (pure compound) (26)

      BOILING POINT:      196 C (pure compound) (26)

      VAPOR PRESSURE:     0.8 mmHg at 21 C (pure compound) (26)

      SOLUBILITY:         1 g/kg water at room temperature (pure compound)

                          III.  HEALTH HAZARD INFORMATION

      OSHA STANDARD:      1 ug/m3 in manufacturing plants (26)




           A.  ACUTE TOXICITY

               DERMAL:    LD50 = 1420 mg/kg (rabbit) (26)

               ORAL:      LD50 = 170-300 mg/kg (rat); 260-400 mg/kg (mouse)

               INHALATION:  Acute vapor toxicity, 103 ppm (8-hour exposure),
                            369 ppm (1-hour exposure) (56).

               EYES:      Not markedly irritant to the eyes (26)


           In 90-day feeding trials the lowest dose level causing a decrease
      in growth rate was:  for female rats 150 mg/kg, for male rats 450
      mg/kg.  In lifetime studies in rats and mice it has been shown by the
      oral gavage to be carcinogenic (26).
           Overexposure can cause reduced sperm count in human males (56).

                        IV.  ENVIRONMENTAL  CONSIDERATIONS

           Not harmful to beneficial soil microorganisms.  Nonhazardous to
      honey bees (48).
           The LC50 (48 hr) is:  for bass 30-50 mg/l; for sunfish 50-125 mg/l
           Many perennial plants tolerate high concentrations but others,
      including potatoes and tobacco, require a long aeration period before
      planting.  It does not persist in soil to the extent that creates an
      accumulation problem (26).


           The chemical information provided below has been condensed
      from original source documents, primarily from "Recognition and
      Management of Pesticide Poisonings", 3rd ed. by Donald P.  Morgan,
      which have been footnoted.  This information has been provided in
      this form for your convenience and general guidance only.  In
      specific cases, further consultation and reference may be required
      and is recommended.  This information is not intended as a sub-
      stitute for a more exhaustive review of the literature nor for the
      judgement of a physician or other trained professional.

           If poisoning is suspected, do not wait for symptoms to develop.
      Contact a physician, the nearest hospital, or the nearest Poison
      Control Center.

      Frequent Symptoms and Signs of Poisoning

           headACHE, DIZZINESS, NAUSEA, and vomiting are prominent early
      symptoms of excessive exposure to these gases (including
           DROWSINESS, TREMORS, double vision, and weakness are the common
      early manifestations of central nervous system impairment.  Tremors may
      progress to myoclonic movements, then to generalized SEIZURES,
      UNCONSCIOUSNESS, and death.
           Injuries to the skin by liquid fumigants may be manifest as areas of
      redness or as BLISTERS which rupture, leaving raw skin or deep ulcers.
           If ingested, the LIQUID forms of HALOCARBONS often cause pulmonary
      edema and SHOCK within a few moments.  If victim survives, injuries to
      the brain, liver and kidney are life-threatening.
           Longer-term low level inhalation of CHLOROCARBONS may cause liver
      damage, first manifest as ANOREXIA, then as JAUNDICE.  Biochemical
      studies confirm hepatocellular injury (25).

           SKIN CONTACT:  In case of contact immediately remove contaminated
      shoes and clothing and wash with soap and water (56).

           INGESTION:     If swallowed, drink 1 or 2 glasses of water and
      induce vomiting by touching back of throat with finger, or blunt
      object.  Do not induce vomiting or give anything by mouth to an
      unconscious person.  Get medical attention (56).

           INHALATION:    If illness results from inhalation, remove to fresh
      air and call a doctor (56).

           EYE CONTACT:   Flush eyes with plenty of water and get medical
      attention (56).


                        VI.  FIRE AND EXPLOSION INFORMATION

           To be developed.

                                VII.  COMPATIBILITY

           Compatible with other soil fumigants, insecticides and dry
      fertilizers.  May be corrosive to aluminum and magnesium (48).

                            VIII.  PROTECTIVE MEASURES

      STORAGE AND HANDLING:  Harmful liquid and vapor.  May be fatal if
      swallowed, inhaled or absorbed through skin.  May cause functional
      infertility.  Combustible mixture causes skin irritation and blisters
      upon prolonged contact.  Causes irritation of eyes, nose, throat.  May
      be absorbed through skin.  Do not allow material to remain on skin.  If
      clothing or shoes become contaminated remove them promptly and do not
      wear again until completely free of material (56).

      PROTECTIVE CLOTHING:  Wear impermeable fullbody clothing except drivers
      of surface soil injection equipment who are only required to wear
      impermeable protective fullbody clothing during mixing, loading and
      transferring operations, and during the calibration of and performance
      of maintenance upon the soil injection equipment to avoid any skin or
      eye contact (56).

      PROTECTIVE EQUIPMENT:  Wear a respirator jointly approved by the Mining
      Enforcement and Safety Administration and National Institute of
      Occupational Safety and Health (56).

                       IX.  PROCEDURES FOR SPILLS AND LEAKS

                                  (800) 424-9300

                               X.  LITERATURE CITED

      22.  U.S. Environmental Protection Agency, Office of Pesticide
               Programs.  1983.  June 1983 status report on rebuttable
               presumption against registration (RPAR) or special review
               process, registration standards and the data call in
               programs.  Washington, DC.  45 pp.

      25.  Morgan, D.P.  1982.  Recognition and management of
               pesticide poisonings, 3rd ed.  U. S. Environmental Protection
               Agency, Washington, DC.  120 pp.

      26.  The Pesticide Manual:  A World Compendium, 6th ed.  1979.  C. R.
               Worthing, ed.  The British Crop Protection Council, Croydon,
               England.  655 pp.

      48.  Harding, W.C.  1979-80.  Pesticide profiles, part two:  fungicides
               and nematicides.  Univ. Maryland, Coop. Ext. Service Bull.
               283, 22 pp.

      56.  Farm Chemicals Handbook, 70th ed.  1984.  R. T. Meister, G. L.
               Berg, C. Sine, S. Meister, and J. Poplyk, eds.  Meister
               Publishing Co., Willoughby, OH.