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anilazine (Dyrene) Chemical Fact Sheet 12/83

                            CHEMICAL FACT SHEET FOR:
                                   ANILAZINE

FACT SHEET NUMBER:  12
DATE ISSUED:  DECEMBER 16, 1983

                    1. DESCRIPTION OF CHEMICAL

Generic Name:  2,4-dichloro-6-(D-chloroanilino)-s-triazine
Common Name:  anilazine
Trade Names:  Dyrene, Direz, Kemate, Triasyn, B-622, Ent-26,058,
  HCl-C08684, 4,6-dichloro-N-(2-chlorophenyl)-l,3.5-triazin-2-amine.
EPA Shaughnessy Code:  080811
Chemical Abstracts Service (CAS) Number:  101-05-3
Year of Initial Registration:  1957
Pesticide Type:  Fungicide
Chemical Family:  Triazine
U.S. and Foreign Producers:  Mobay Chemical Corporation

              2. USE PATTERNS AND FORMULATIONS

Application sites:  turf, tobacco, ornamentals, various fruits and vegetables
Types of formulations:  dust, wettable powder, granular
Types and methods of application:  foliar application, additive to vinyl
  plastics
Application rates:  1.0 to 3.0 lb active ingredient per acre
Usual carriers:  water

                   3. SCIENCE FINDINGS

Chemical Characteristics

Anilazine is a white to tan crystalline solid. It is stable in neutral to 
slightly acidic media and subject to hydrolysis. It has a melting point of 
159-160 C. The chemical does not present any unusual handling hazards.

Toxicological Characteristics

Anilazine is considered a skin sensitizer. It demonstrates low toxicity from 
oral routes of exposure. The chemical has been found to be highly toxic to 
fish and aquatic invertebrates.

Acute toxicology results:

- Oral LD50 in rats:  2.71 g/kg body weight (28-33) days) 
  (Toxicity Category III)
- Oral LD50 in rabbits:  460 mg/kg (Toxicity Category II)
- Oral LD50 in dogs:  MLD > 7.1 g/kg (Toxicity Category IV)
- Oral LD50 in monkeys:  MLD > 3.2 g/kg (Toxicity Category III)
- Dermal LD50 in rabbits:  > 9.4 g/kg (intact skin) (Toxicity 
  Category III) > 2.5 g/kg (abraded skin)
- Eye irritation in rabbits:  Corneal opacity in 3/6 animals, iris
  irritation. redness, chemosis which persisted through day 21
  (Toxicity Category I)

Chronic toxicology results:
- Rat and mouse oncogenicity studies were negative at dose levels
  tested (500 and 1000 ppm). Clinical toxic signs were noted at
  both doses in second year.

- Major routes of exposure:  dermal

Environmental Characteristics

- Microbial breakdown:  Anilazine is degraded rapidly in both moist and
  dry soils under aerobic conditions, with half-lives of 0.5 and 2.5
  days, respectively.

- Adsorption and leaching in basic soil types:  Anilazine is classified
  to be of intermediate mobility in a sandy loam and of low mobility
  in agricultural sand, sandy clay loam, silt loam, and silty clay
  soils based on soil TLC.

Ecological Characteristics

Hazards to fish and wildlife:

- Avian dietary LC50:  Anilazine did not cause 50% mortality when birds were
  exposed to a diet containing 5000 ppm for > 10 to < 100 days
- Avian oral LD50:  > 2,000 mg/kg
- Fish LC50:  0.14 to 0.326 ppm (highly toxic)
- Aquatic invertebrate LC50:  0.270 ppm (highly toxic)

Tolerance Assessment

- Due to the absence of pertinent data, the Agency is unable to complete its
  reassessment of anilazine tolerances.

- List of present tolerances:

  Crop                               ppm

Blackberries                        10.0
Blueberries                         10.0
Celery                              10.0
Cranberries                         10.0
Cucumbers, including pickles        10.0
Dewberries                          10.0
Garlic                               1.0
Onions, dry bulb                     1.0
Onions, green                       10.0
Potatoes.............................1.0

Problems Known to Have Occurred From Use

The Pesticide Incident Monitoring System (PIMS) includes a report of 
dermatitis and delayed dermal hypersensitivity in several laborers hand-
harvesting anilazine-treated strawberries and tomatoes in Tennessee. With 
treatment recovery required at least one week, but symptoms recurred with 
increased severity upon re-exposure.

Summary Science Statement

Extensive data gaps exist for anilazine. No human toxicological hazards of 
concern have been identified in studies reviewed by the Agency for the 
standard. The Agency has no information that indicates continued use will 
result in any unreasonable adverse effects to man or his environment during 
the time required to develop the data.

             4. SUMMARY OF REGULATORY POSITION AND RATIONALE

Use classification:  General

Unique label warning statements:

All product labeling is required to bear the statement:  Protective clothing 
should be worn during periods of exposure, such as during application, or when 
contacting treated foliage.

Manufacturing-use labels must contain the statements:  This pesticide is toxic 
to fish and aquatic invertebrates. Do not discharge into lakes. streams, 
ponds, or public water unless in accordance with an NPDES permit. For 
guidance, contact your Regional Office of EPA.

All end-use labels, except those for use on cranberries, must contain the 
statements:  This pesticide is toxic to fish and aquatic invertebrates. Do not 
apply directly to water or wetlands. Drift and runoff from treated areas may 
be hazardous to aquatic organisms in neighboring areas. Do not contaminate 
water by cleaning of equipment or disposal of wastes.

All end-use labels for use on cranberries must contain the statements:  This 
pesticide is toxic to fish and aquatic invertebrates. Movement from treated 
areas may be hazardous to aquatic organisms in neighboring areas. Do not 
contaminate water by cleaning of equipment or disposal of wastes.

All end-use labels must contain the following statements:  Do not use on seed 
crops intended to be used for feed or forage. Do not graze treated areas. Do 
not reenter treated fields within 24 hours following application of this 
product.

                5. SUMMARY OF MAJOR DATA GAPS

Product Chemistry (Due August, 1984)

- Product identity
- Analysis and certification of product ingredients
- Physical and chemical characteristics

Residue Chemistry (Due June, 1986)

- Nature of residue and analytical method for plants and animal
  residues
- Storage stability data
- Crop field trials on all crops except cucumbers, summer squash
  dewberries, loganberries, and raspberries
- Processed food/feed studies on potatoes and tomatoes

Environmental Fate (Due December, 1987)

- Hydrolysis
- Photodegradation
- Metabolism studies
- Mobility studies
- Soil and aquatic dissipation studies
- Accumulation studies

Toxicology (Due December, 1987)

- Inhalation LC50 - rat
- 21-day dermal
- 90-day dermal (vinyl additive use only)
- 90-day inhalation-rat
- Chronic toxicity - rodent and non-rodent
- Teratogenicity - 2 species
- Reproduction - 2 generation
- Mutagenicity testing
- General metabolism
- Reentry Protection (Due December, 1987)
- Dermal exposure
- Wildlife and Aquatic Organisms (Due December, 1987)
- Avian oral LD50
- Avian dietary LC50 - upland game bird and waterfowl
- Acute LC50 - freshwater invertebrates
- Fish early life stage and aquatic invertebrate life cycle -
  invertebrate and fish

              6. CONTACT PERSON AT EPA

Henry M. Jacoby
EPA (TS-767C)
401 M. St., SW
Washington, DC  20460

(703) 557-1900

DISCLAIMER:  THE INFORMATION PRESENTED IN THIS CHEMICAL INFORMATION FACT SHEET 
IS FOR INFORMATIONAL PURPOSES ONLY AND NOT TO BE USED TO FULFILL DATA 
REQUIREMENTS FOR PESTICIDE REGISTRATION AND REREGISTRATION.