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carboxin (Vitavax) Chemical Profile 1/85

                                      carboxin

      CHEMICAL NAME:      5,6-dihydro-2-methyl-1,4-oxathiin-3-carboxamide (56)

      TRADE NAME(S):      Vitavax (48)

      FORMULATION(S):     75% wettable powder, 17% flowable, in combination
                          with captan and thiram (48).

      TYPE:               Organic fungicide

      BASIC PRODUCER(S):  Uniroyal Chemical Co.
                          Emic Bldg.
                          Naugatuck, CT

      STATUS:             General use

      PRINCIPAL USES:  Systemic seed protectant for wheat, oats, corn and
      barley seed against smuts, bunts and other diseases (48).
           Used against Rhizoctonia spp. of vegetables (26).


                                   I.  EFFICACY

           To be developed.


                             II.  PHYSICAL PROPERTIES

      MOLECULAR FORMULA:  C12 H13 NO2 S (26)

      MOLECULAR WEIGHT:   235.3 (26)

      PHYSICAL STATE:     Colorless solid (pure compound) (26)

      MELTING POINT:      91.5-92.5 C; a dimorphic form has m.p. 98-100 C
                          (pure compound) (26).

      SOLUBILITY:         170 mg/l water at 25 C (pure compound) (26)


                          III.  HEALTH HAZARD INFORMATION

      OSHA STANDARD:  NA

      NIOSH RECOMMENDED LIMIT:  NA

      ACGIH RECOMMENDED LIMIT:  NA

      TOXICOLOGY

           A.  ACUTE TOXICITY

               DERMAL:  LD50 = >8000 mg/kg (rabbit) (56)

               ORAL:    LD50 = 3820 mg/kg (rat) (56)

           B.  SUBACUTE AND CHRONIC TOXICITY:

           In 2-year feeding trials albino rats receiving 600 mg/kg diet
      suffered no detectable symptom (26).


                        IV.  ENVIRONMENTAL  CONSIDERATIONS

           Hazardous to fish.  Relatively nonhazardous to honey bees.
      Nonphytotoxic when used as directed.  Does not persist in the soil (48).


                      V.  EMERGENCY AND FIRST AID PROCEDURES

           The chemical information provided below has been condensed
      from original source documents, primarily from "Recognition and
      Management of Pesticide Poisonings", 3rd ed. by Donald P.  Morgan,
      which have been footnoted.  This information has been provided in
      this form for your convenience and general guidance only.  In
      specific cases, further consultation and reference may be required
      and is recommended.  This information is not intended as a sub-
      stitute for a more exhaustive review of the literature nor for the
      judgement of a physician or other trained professional.

           If poisoning is suspected, do not wait for symptoms to develop.
      Contact a physician, the nearest hospital, or the nearest Poison
      Control Center.

           SKIN CONTACT:  Flush with plenty of water.  Wash skin with soap
                          and water (21c).

           INGESTION:     Induce vomiting and see a physician (41b).

           INHALATION:    See a physician if an abnormal reaction occurs
                          (41b).

           EYE CONTACT:   Flush with plenty of water (21c).


                        VI.  FIRE AND EXPLOSION INFORMATION

           To be developed.


                                VII.  COMPATIBILITY

           Compatible with other pesticides used as seed treatments (48).


                            VIII.  PROTECTIVE MEASURES

      STORAGE AND HANDLING:  Do not contaminate food or feedstuffs.  Keep out
      of reach of children.  Avoid inhaling dust or spray mist.  Do not get
      in eyes or on skin.  Do not graze or feed livestock on treated areas
      for ten weeks after planting.  Do not spill treated grain or otherwise
      expose to wild birds.  Do not store treated seed longer than one year
      (21c).  Store in a cool dry place (56).

      PROTECTIVE EQUIPMENT:  Wear a mask suitable for protection against
      Vitavax dust or spray vapors when applying this chemical to seed (21c).


                       IX.  PROCEDURES FOR SPILLS AND LEAKS

                     IN CASE OF EMERGENCY, CALL, DAY OR NIGHT
                                  (800) 424-9300
                      PESTICIDE TEAM SAFETY NETWORK/CHEMTREC


                               X.  LITERATURE CITED

      21c. Canada Department of Agriculture, Production and Marketing Branch,
               Plant Products Division.  1970.  Memorandum (re:  Vitavax).
               Ottawa, Ontario, Canada.

      26.  The Pesticide Manual:  A World Compendium, 6th ed.  1979.  C. R.
               Worthing, ed.  The British Crop Protection Council, Croydon,
               England.  655 pp.

      41b. Uniroyal Chemical, Division of Uniroyal, Inc.  1977.  Specimen
               label:  Vitavax fungicide.  Naugatuck, CT.

      48.  Harding, W.C.  1979-80.  Pesticide profiles, part two:  fungicides
               and nematicides.  Univ. Maryland, Coop. Ext. Service Bull.
               283, 22 pp.

      56.  Farm Chemicals Handbook, 70th ed.  1984.  R. T. Meister, G. L.
               Berg, C. Sine, S. Meister, and J. Poplyk, eds.  Meister
               Publishing Co., Willoughby, OH.

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