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etridiazole (Ethazol, Terrazole) Chemical Profile 2/85

                                      ethazol

      CHEMICAL NAME:      5-Ethoxy-3-trichloromethyl-1,2,4-thiadiazole (56)

      TRADE NAME(S):      Koban, Dwell, TerraFlo, Truban, Terrazole (56)

      FORMULATION(S):     Wettable powder 35%, 25% emulsifiable, and 4 lb./
                          gal. emulsifiable, 5% granular (56)

      TYPE:               Organic fungicide

      BASIC PRODUCER(S):  Mallinckrodt Chemical Co.
                          P.O. Box 5439
                          St. Louis, MO 63147

                          Olin Corp.
                          First National Bldg.
                          P.O. Box 991
                          Little Rock, AR 72203

      STATUS:             General use

      PRINCIPAL USES:  Soil treatment against seeding and other diseases
      on field crops, vegetables and ornamentals (48).


                                   I.  EFFICACY

           Controls Pythium at low rates (56).


                             II.  PHYSICAL PROPERTIES

      MOLECULAR FORMULA:  C5 H5 Cl3 N2 O S (26)

      MOLECULAR WEIGHT:   247.5 (26)

      PHYSICAL STATE:     Pale yellow liquid (pure compound); reddish brown
                          liquid (technical product) (26).

      ODOR:               Persistent odor (pure compound) (26)

      VAPOR PRESSURE:     1 x 10-4 mmHg at room temperature (pure compound)
                          (26)

      SOLUBILITY:         50 mg/l water at 25 C (pure compound) (26)


                          III.  HEALTH HAZARD INFORMATION

      OSHA STANDARD:  NA

      NIOSH RECOMMENDED LIMIT:  NA

      ACGIH RECOMMENDED LIMIT:  NA

      TOXICOLOGY

           A.  ACUTE TOXICITY

               DERMAL:  LD50 = 1700 mg/kg (rabbit) (6)

               ORAL:    LD50 = 4000 mg/kg (rat) (6)
                        LD50 = 2000 mg/kg (mouse) (26)
                        LD50 = 1077 mg/kg (rat) (56)

           B.  SUBACUTE AND CHRONIC TOXICITY:

           To be developed.

                        IV.  ENVIRONMENTAL  CONSIDERATIONS

           Some hazard to fish.  Nonphytotoxic when used as directed (48).


                      V.  EMERGENCY AND FIRST AID PROCEDURES

           The chemical information provided below has been condensed
      from original source documents, primarily from "Recognition and
      Management of Pesticide Poisonings", 3rd ed. by Donald P.  Morgan,
      which have been footnoted.  This information has been provided in
      this form for your convenience and general guidance only.  In
      specific cases, further consultation and reference may be required
      and is recommended.  This information is not intended as a sub-
      stitute for a more exhaustive review of the literature nor for the
      judgement of a physician or other trained professional.

           If poisoning is suspected, do not wait for symptoms to develop.
      Contact a physician, the nearest hospital, or the nearest Poison
      Control Center.

      KNOWN OR SUSPECTED ADVERSE EFFECTS:  Moderately irritating to skin,
      eyes, and respiratory tract (25).

           SKIN CONTACT:  Wash contaminated skin with soap and water (25).

           INGESTION:  Ingestions of small amounts (less than 10 mg/kg
      body weight) occurring less than an hour before treatment, are probably
      best treated by:  Syrup of Ipecac, followed by 1-2 glasses of water.
      Dose for adults and children over 12 years:  30 ml.  Dose for children
      under 12 years:  15 ml (25).

           EYE CONTACT:   Flush contaminated eyes with copious amounts of
      fresh water for 15 minutes (25).

      NOTES TO PHYSICIAN:

      INGESTIONS of LARGE amounts (more than 10 mg/kg) occurring less than an
      hour before treatment, should probably be treated by gastric lavage:
      A.   INTUBATE stomach and ASPIRATE contents.
      B.   LAVAGE stomach with slurry of ACTIVATED CHARCOAL IN 0.9% saline.
           Leave 30-50 gm activated charcoal in the stomach before
           withdrawing tube.
      C.   SODIUM SULFATE, 0.25 gm/kg in tap water, as a cathartic.
           CAUTION:  Hydrocarbons (kerosene, petroleum distillates) are
                     included in some formulations of these chemicals.
                     Ingestion of very LARGE AMOUNTS may cause CNS
                     depression.  In this case, IPECAC IS CONTRAINDICATED.
                     Also, gastric intubation incurs a risk of HYDROCARBON
                     PNEUMONITIS.  For this reason observe the following
                     precautions:
                     (1)  If the victim is unconscious or obtunded and
                          facilities are at hand, insert an ENDOTRACHEAL TUBE
                          (cuffed, if available) prior to gastric intubation.
                     (2)  Keep victim's HEAD BELOW LEVEL OF STOMACH during
                          intubation and lavage (Trendelenburg, or left
                          lateral decubitus, with head of table tipped
                          downward).  Keep victim's head turned to the left.
                     (3)  ASPIRATE PHARYNX as regularly as possible to remove
                          gagged or vomited stomach contents.
      INGESTIONS occurring MORE THAN an HOUR before treatment are probably
      best treated only by ACTIVATED CHARCOAL, 30-50 gm, and SODIUM or
      MAGNESIUM SULFATE, 0.25 gm/kg, as described above.
      There are no specific antidotes for these chemicals.  Because
      manifestations of toxicity do occasionally occur in peculiarly
      predisposed individuals, MAINTAIN CONTACT with victim for at least 72
      hours so that unexpected adverse effects can be treated promptly (25).


                        VI.  FIRE AND EXPLOSION INFORMATION

           To be developed.


                                VII.  COMPATIBILITY

           Do not mix with other pesticides or fertilizers (48).


                             VIII.  PROTECTIVE MEASURES

           To be developed.


                       IX.  PROCEDURES FOR SPILLS AND LEAKS

                     IN CASE OF EMERGENCY, CALL, DAY OR NIGHT
                                  (800) 424-9300
                      PESTICIDE TEAM SAFETY NETWORK/CHEMTREC


                               X.  LITERATURE CITED

       6.  Farm Chemicals Handbook, 66th ed.  1980.  G. L. Berg, C. Sine,
               S. Meister, and H. Shephard, eds.  Meister Publ. Co.,
               Willoughby, OH.

      25.  Morgan, D.P.  1982.  Recognition and management of
               pesticide poisonings, 3rd ed.  U. S. Environmental Protection
               Agency, Washington, DC.  120 pp.

      26.  The Pesticide Manual:  A World Compendium, 6th ed.  1979.  C. R.
               Worthing, ed.  The British Crop Protection Council, Croydon,
               England.  655 pp.

      48.  Harding, W.C.  1979-80.  Pesticide profiles, part two:  fungicides
               and nematicides.  Univ. Maryland, Coop. Ext. Service Bull.
               283, 22 pp.

      56.  Farm Chemicals Handbook, 70th ed.  1984.  R. T. Meister, G. L.
               Berg, C. Sine, S. Meister, and J. Poplyk, eds.  Meister
               Publishing Co., Willoughby, OH.

      2/5/85