fenamiphos (Nemacur) Chemical Profile 2/85
CHEMICAL NAME: Ethyl 3-methyl-4-(methylthio) phenyl (1-methylethyl)
TRADE NAME(S): Nemacur (48)
FORMULATION(S): Emulsifiable concentrate and granule (56)
TYPE: Organophosphorus nematicide
BASIC PRODUCER(S): Mobay Chemical Corp.
Agri. Chemicals Div.
P.O. Box 4913
Kansas City, MO 64120
STATUS: Restricted use
PRINCIPAL USES: Systemic and contact poison against the major
genera of nematodes attacking field crops, vegetables and turf (48).
A compound with high nematicidal activity which can be applied
broadcast, in-the-row, in band, by drench, before or at planting time,
or to established plants. Complete soil incorporation is not
Results show it to be a broad spectrum nematicide with good plant
tolerance to many field, vegetable, and fruit crops. Presently
registered for control of the major genera of nematodes attacking cotton,
peanuts, soybeans, cabbage, Brussels sprouts, bananas, turf grasses,
and non-bearing fruit trees in many major fruit producing states.
Currently under research in areas where nematodes are a problem (56).
Nematicidal activity has been reported against endoparasitic,
ectoparasitic, cyst forming and root-knotting species belonging to the
genera Belonolaimus, Criconemoides, Helicotylenchus, Hemicycliophora,
Heterodera, Meloidogyne, Paratylenchus, Pratylenchus, Radopholus,
Rotylenchus, Trichodorus, Tylenchorynchus, Tylenchulus, and Tylenchus
species. Results also indicate that Nemacur is active against golden
nematodes (Heterodera rostochiensis) infesting potatoes.
Preliminary data indicate that Nemacur is systemically active
against aphids, mites, thrips, fleahoppers, mealybugs, and adult
cucumber beetles. Excellent insecticidal and acaricidal activity has
also been noted with foliar applications of Nemacur on a broad spectrum
of field and vegetable crops (5c).
II. PHYSICAL PROPERTIES
MOLECULAR FORMULA: C13 H22 NO3 PS (26)
MOLECULAR WEIGHT: 303.4 (26)
PHYSICAL STATE: Colorless solid (pure compound) (26)
MELTING POINT: 49 C (pure compound) (26)
VAPOR PRESSURE: 1 x 10-6 mmHg at 30 C (pure compound) (26)
SOLUBILITY: c. 700 mg/l water at room temperature (pure
III. HEALTH HAZARD INFORMATION
OSHA STANDARD: NA
NIOSH RECOMMENDED LIMIT: NA
ACGIH RECOMMENDED LIMIT: NA
A. ACUTE TOXICITY
DERMAL: LD50 = 178-225 mg/kg (rabbit, technical) (56)
ORAL: LD50 = 8.1-9.6 mg/kg (rat, technical) (56)
INHALATION: LC50 = 110 ug/l/60 min (male rat, technical);
LC50 = 150 ug/l/60 min (female rat, technical) (5c)
B. SUBACUTE AND CHRONIC TOXICITY:
In 2-year feeding trails rats receiving 3 mg/kg diet showed no
symptom of poisoning (26).
IV. ENVIRONMENTAL CONSIDERATIONS
Hazardous to fish. Soil applications not normally phytotoxic
V. EMERGENCY AND FIRST AID PROCEDURES
The chemical information provided below has been condensed
from original source documents, primarily from "Recognition and
Management of Pesticide Poisonings", 3rd ed. by Donald P. Morgan,
which have been footnoted. This information has been provided in
this form for your convenience and general guidance only. In
specific cases, further consultation and reference may be required
and is recommended. This information is not intended as a sub-
stitute for a more exhaustive review of the literature nor for the
judgement of a physician or other trained professional.
If poisoning is suspected, do not wait for symptoms to develop.
Contact a physician, the nearest hospital, or the nearest Poison
FREQUENT SYMPTOMS AND SIGNS OF POISONING BY ORGANOPHOSPHATE PESTICIDES
Symptoms of acute poisoning develop during exposure or within 12
hours (usually within four hours) of contact. HEADACHE, DIZZINESS,
WEAKNESS, INCOORDINATION, MUSCLE TWITCHING, TREMOR, NAUSEA, ABDOMINAL
CRAMPS, DIARRHEA, and SWEATING are common early symptoms. Blurred or
dark vision, confusion, tightness in the chest, wheezing, productive
cough, and PULMONARY EDEMA may occur. Incontinence, unconsciousness
and convulsions indicate very severe poisoning. SLOW HEARTBEAT,
salivation, and tearing are common. TOXIC PSYCHOSIS, with manic or
bizarre behavior, has led to misdiagnosis of acute alcoholism. Slowing
of the heartbeat may rarely progress to complete sinus arrest.
RESPIRATORY DEPRESSION may be fatal. Continuing daily absorption of
organophosphate at intermediate dosage may cause an INFLUENZA-LIKE
ILLNESS characterized by weakness, anorexia, and malaise (25).
SKIN CONTACT: Bathe and shampoo victim with soap and water if
there is any chance that skin and hair are contaminated (25).
INGESTION: If victim is alert and respiration is not
depressed, give Syrup of Ipecac, followed by 1-2 glasses of water to
induce vomiting. Adults (12 years and over): 30 ml; children under 12
years: 15 ml (25).
NOTES TO PHYSICIAN:
Administer ATROPINE SULFATE intravenously, or intramuscularly, if IV
injection is not possible.
In MODERATELY SEVERE poisoning: Adult dosage: 0.4-2.0 mg repeated
every 15 minutes until atropinization is achieved: tachycardia (pulse
of 140 per minute), flushing, dry mouth, dilated pupils. Maintain
atropinization by repeated doses for 2-12 hours or longer depending on
severity of poisoning.
Dosage for children under 12 years: 0.05 mg/kg body weight, repeated
every 15 minutes until atropinization is achieved. Maintain
atropinization with repeated dosage of 0.02-0.05 mg/kg.
SEVERELY POISONED individuals may exhibit remarkable tolerance to
atropine; two or more times the dosages suggested above may be needed.
Administer PRALIDOXIME (Protopam (TM)-Ayerst, 2-PAM) in cases of severe
poisoning in which respiratory depression, muscle weakness and
twitchings are severe.
Adult dosage: 1.0 gm intravenously at no more than 0.5 gm per minute.
Child's dose (under 12 years): 20-50 mg/kg (depending on severity of
poisoning) intravenously, injecting no more than half the total dose
Dosage of pralidoxime may be repeated in 1-2 hours, then at 10-12 hour
intervals if needed. In very severe poisonings, dosage rates may be
VI. FIRE AND EXPLOSION INFORMATION
To be developed.
Incompatible with pesticides alkaline in reaction (48).
VIII. PROTECTIVE MEASURES
To be developed.
IX. PROCEDURES FOR SPILLS AND LEAKS
IN CASE OF EMERGENCY, CALL, DAY OR NIGHT
PESTICIDE TEAM SAFETY NETWORK/CHEMTREC
X. LITERATURE CITED
5c. Chemagro Division of Baychem Corporation. 1973. Technical
information: Nemacur nematicide. Kansas City, MO.
25. Morgan, D.P. 1982. Recognition and management of
pesticide poisonings, 3rd ed. U. S. Environmental Protection
Agency, Washington, DC. 120 pp.
26. The Pesticide Manual: A World Compendium, 6th ed. 1979. C. R.
Worthing, ed. The British Crop Protection Council, Croydon,
England. 655 pp.
48. Harding, W.C. 1979-80. Pesticide profiles, part two: fungicides
and nematicides. Univ. Maryland, Coop. Ext. Service Bull.
283, 22 pp.
56. Farm Chemicals Handbook, 70th ed. 1984. R. T. Meister, G. L.
Berg, C. Sine, S. Meister, and J. Poplyk, eds. Meister
Publishing Co., Willoughby, OH.