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fenarimol (Rubigan) Chemical Fact Sheet 2/85

                         CHEMICAL FACT SHEET FOR:
                                FENARIMOL

FACT SHEET NUMBER:  46

DATE ISSUED:  FEBRUARY 27, 1985


                     1.  DESCRIPTION OF CHEMICAL

- Generic Name:  alpha-(2-chlorophenyl)-alpha-(4-chlorophenyl)-5-
  pyrimidinemethanol
- Common Name:  Fenarimol
- Trade Name:  Rubigan
- EPA Shaughnessy Code:  206600
- Chemical Abstracts Service (CAS) Number:  60168-88-9
- Year of Initial Registration:  1984
- Pesticide Type:  Applied local systemic fungicide
- Chemical Family:  Substituted pyrimidine
- U.S. and Foreign Producers:  Elanco Products Company


                 2.  USE PATTERNS AND FORMULATIONS

- Application sites:  Field and greenhouse grown roses and ornamentals,
  turf, lawns, and golf courses
- Types of formulations:  2.5% emulsifiable concentrate and 50% wettable
  powder
- Types and methods of application:  Commercial spray equipment
- Application rates:  0.25 - 5.0 pounds of active ingredient per acre
  for grass use; 0.075 - 0.2 ounces of active ingredient per 100
  gallons for roses and ornamentals
- Usual carriers:  Water


                         3.  SCIENCE FINDINGS

Chemical Characteristics

- Physical state:  Crystalline solid
- Color:  White to off-white
- Odor:  None
- Melting point:  114-116  degrees C
- Solubility:  Fenarimol is soluble in such organic solvents as
  acetone, acetonitrite, benzene, chloroform, and methanol, but only
  slightly soluble in hexane and practically insoluble in water.


Toxicological Characteristics

- Oral LD50 - Category III
- Dermal LD50 - Category III
- Inhalation LC50 - Category III
- Eye irritation - Category III
- Skin irritation - Category III
- Guinea pig sensitization - not a skin sensitizer
- Rabbit teratology - negative at 35 mg/kg (highest dose tested)
- Rat teratology - teratogenic (hydronephosis) at 35 mg/kg; NOEL 13
  mg/kg
- Rat reproduction (1st study) - NOEL 50 ppm; LEL 130 ppm (infertility);
  test levels 0, 50, 130, & 350 ppm
- Rat reproduction (2nd study) - NOEL 12.5 ppm; LEL 50 ppm
- Guinea pig reproduction - no compound related adverse effect on
  fertility in male and female guinea pigs at 35 mg/kg/day.
- 2 year rat chronic feeding/oncogenicity - statistically significant
  increase in hepatic adenomas and hyperplastic nodules at 350 ppm
  (highest dose tested); NOEL 130 ppm (weight loss)
- 18 month mouse oncogenicity - negative at all dose levels; NOEL 50
  ppm; LEL 130 ppm (atrophy of thymus); test levels 0, 50, 130,
  & 350 ppm
- 90 day dog feeding - NOEL >20 mg/kg
- Mutagenicity
  - Mouse: lymphoma forward mutation assay - negative at 100 micrograms/
    ml with and without enzyme activation
  - Rat dominant lethal - negative at single dose of 350 mg/kg
  - Salmonella typhinurium and E. coli - negative at 100 micrograms/
    ml with and without enzyme activation
  - DNA repair synthesis - negative in primary rat liver culture system

Turf use:
- Oncogenic risks:                         Exposure/day     Risk
                                           for lifetime
________________________________________________________________________

  Applicator/mixer/loader                 .000317 mg     2.78 x 10(-6)
 with protective clothing
  Irrigation/mower                        .000717 mg     6.30 x 10(-6)
  Golfer                                  .000043 mg     3.80 x 10(-7)

  20 kg. child                            .000014 mg     1.20 x 10(-7)

- Teratogenic margins of safety            Exposure/day        MOS

  Applicator/mixer/loader                 .01670  mg           778
 with protective clothing
  Irrigation/mower                        .00250  mg          5200
  Golfer                                  .00015  mg         86667

Ornamentals and roses:
- Oncogenic risks (roses)                  Exposure/day     Risk
                                           for lifetime
  Mixer/loader with
 protective clothing
      Field                               .000011 mg  9.8 x 10(-8)
      Greenhouse                          .000011 mg  9.8 x 10(-8)

  Applicator with
 protective clothing
      Field                               .000023 mg  2.02 x 10(-7)
      Greenhouse                          .000046 mg  4.0 x 10(-7)

  Reentry (field)
      1st day                             .0000055 mg  4.84 x 10(-8)
      2nd day                             .000021 mg   1.85 x 10(-7)
  Reentry (greenhouse)
      4-5 hours                           .00007 mg    6.2 x 10(-7)

- Teratogenic margins of safety            Exposure/day       MOS

  Mixer/loader with
 protective clothing
      Field                               .0015  mg           420
      Greenhouse                          .0015  mg           420
  Applicator with
 protective clothing
      Field                               .003 mg             290
      Greenhouse                          .006 mg             104
  Reentry (field)
      1st day                             .00074 mg           889
      2nd day                             .00051 mg         1,232
  Reentry (greenhouse)
      4-5 hours                           .0045 mg          2.888


Environmental Characteristics

  Fenarimol is degraded in the environment through photodegradation
  with a half-life of approximately 12 hours.  The chemical does not
  degrade in soil under aerobic or anaerobic conditions.  The chemical
  has a bioconcentration factor of 113.  Fenarimol is not likely to
  volatilize, nor is it expected to leach in the soil.


Ecological Characteristics

- Oral LD50 (bobwhite quail)        >2000 mg/kg
- Dietary LC50 (bobwhite quail)     >6125 ppm
- Dietary LC50 (mallard duck)       >6250 ppm
- Acute LC50 (bluegill sunfish)     0.9 ppm
- Acute LC50 (rainbow trout)        2.1 ppm
- Acute LC50 (Daphnia magna)        6.8 ppm
- Mallard duck reproduction         No effects at 250 ppm
- Bobwhite quail reproduction       No effects at 125 ppm
- Honeybee toxicity                 No effects to bees fed 10 or 100
  ppm; however, reduced longevity was observed at 1000 ppm


Summary Science Statement

- Fenarimol is primarily a surface residue that degrades due to photo-
  degradation into many different degradates.  None of the degradates
  comprise a significant portion of the total residues.  Fenarimol is
  immobile in soils and not likely to leach beyond 12 cm into the
  soil.  Fenarimol demonstrates very low toxic effects to mammals and
  birds.  It is moderately to highly toxic to fish and daphnids.
- Fenarimol demonstrates low toxicity via oral, inhalation, skin, and
  eye routes of exposure.  However, the chemical does produce
  reproductive, teratogenic, and oncogenic effects in laboratory
  animals.  The chemical inhibits testosterone aromatase activity,
  which results in irreversible infertility in male rats.  The
  inhibition of testosterone aromatase is not involved in the fertility
  of guinea pigs and humans.


         4.  SUMMARY OF REGULATORY POSITION AND RATIONALE

- Unique warning statements required on labels
  - Under ENVIRONMENTAL HAZARDS:  This product is toxic to fish.  Do not
    apply directly to water.  Do not apply when weather conditions
    favor runoff or drift from the target area.  Do not contaminate
    water by cleaning of equipment or disposal of wastes.
  - Under DIRECTIONS FOR USE:  Note to User:  Wear long-sleeved shirt,
    long pants, and gloves when mixing, loading, or using this product.
- Summary of risk/benefit review
  Oncogenic risks are 10(-6) or less, and teratogenic margins of safety
  are above 100.  Benefits achieved will be similar to the benefits
  obtained with chlorothalonil, benomyl, bayleton, and cycloheximide.


                  5.  SUMMARY OF MAJOR DATA GAPS

None


                    6.  CONTACT PERSON AT EPA

Henry M. Jacoby
Product Manager (21)
Herbicide-Fungicide Branch
Registration Division (TS-767C)
Crystal Mall No. 2
1921 Jefferson Davis Highway
Arlington, VA  22202
(703) 557-1900


DISCLAIMER:  THE INFORMATION PRESENTED IN THIS CHEMICAL INFORMATION FACT 
SHEET IS FOR INFORMATIONAL PURPOSES ONLY AND NOT TD BE USED TO FULFILL 
DATA REQUIREMENTS FOR PESTICIDE REGISTRATION AND REREGISTRATION.