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folpet (Phaltan) Chemical Profile 1/85

                                       folpet

      CHEMICAL NAME:      N-(Trichloromethylthio)phthalimide (6)

      TRADE NAME(S):      Phaltan (48)

      FORMULATION(S):     Wettable powder 50%, various dusts (56).

      TYPE:               Organic fungicide

      BASIC PRODUCER(S):  Chevron Chemical Co.
                          Ortho Agricultural Chemicals Div.
                          575 Market St.
                          P.O. Box 3744
                          San Francisco, CA 94105

      STATUS:             General use

      PRINCIPAL USES:  Used on fruits, berries, vegetables, flowers, and
      ornamentals.  Controls apple scab, cherry leaf spot, rose black spot,
      rose mildew.  Used for seed and plant bed treatment.  Industrial uses
      include paints and plastics for fungal control (56).  Nonsystemic (48).
           Folpet is a protective fungicide used mainly for foliage application
      against Alternaria, Botrytis, Rhizoctonia, Pythium and Venturia spp.,
      leaf spot, powdery and downy mildews (26).


                                   I.  EFFICACY

           To be developed.


                             II.  PHYSICAL PROPERTIES

      MOLECULAR FORMULA:  C9 H4 Cl3 NO2 S (26)

      MOLECULAR WEIGHT:   296.6 (26)

      PHYSICAL STATE:     Colorless crystals (pure compound) (26)

      MELTING POINT:      177 C (pure compound) (26)

      VAPOR PRESSURE:     >10-5 mmHg at 20 C (pure compound) (26)

      SOLUBILITY:         1 mg/l water (pure compound) (26)


                          III.  HEALTH HAZARD INFORMATION

      OSHA STANDARD:  NA

      NIOSH RECOMMENDED LIMIT:  NA

      ACGIH RECOMMENDED LIMIT:  NA

      TOXICOLOGY

           A.  ACUTE TOXICITY

               DERMAL:  LD50 = >22,600 mg/kg (rabbit) (26)
                        Contact with skin can result in local irritation
                        (26).

               ORAL:    Rats survived oral administration of 10,000 mg/kg
                        (26).

               INHALATION:  Inhalation of dust or spray mists can result in
                            local irritation (26).

               EYES:    Contact with eyes can result in local irritation (26).

           B.  SUBACUTE AND CHRONIC TOXICITY:

           In 1.4-yr. feeding trials no ill-effect, histopathological change
      or significant difference in tumor incidence was noted in albino rats
      receiving 10,000 tech. mg/kg diet, no adverse effect was noted for dogs
      receiving 1500 mg/kg 5 d/week.  No significant effect on reproductive
      performance was observed over 3 generations in rats at 1000 mg/kg diet;
      no teratogenic effect was noted in 2 species of monkeys, hamsters and
      rats.  Treatment of male mice by Bateman's dominant lethal procedure
      did not induce dominant lethal mutations as measured by increase in
      early post-implantation deaths (26).


                        IV.  ENVIRONMENTAL  CONSIDERATIONS

           Some hazard to fish.  Nonhazardous to honey bees.  Phytotoxic
      effects seen in some varieties of apples, pears, sweet cherries,
      peaches and snapdragons (48).


                      V.  EMERGENCY AND FIRST AID PROCEDURES

           The chemical information provided below has been condensed
      from original source documents, primarily from "Recognition and
      Management of Pesticide Poisonings", 3rd ed. by Donald P.  Morgan,
      which have been footnoted.  This information has been provided in
      this form for your convenience and general guidance only.  In
      specific cases, further consultation and reference may be required
      and is recommended.  This information is not intended as a sub-
      stitute for a more exhaustive review of the literature nor for the
      judgement of a physician or other trained professional.

           If poisoning is suspected, do not wait for symptoms to develop.
      Contact a physician, the nearest hospital, or the nearest Poison
      Control Center.

      KNOWN OR SUSPECTED ADVERSE EFFECTS:  Skin irritant (25).

           SKIN CONTACT:  Wash contaminated skin with soap and water (25).

           INGESTION:  Ingestions of small amounts (less than 10 mg/kg
      body weight) occurring less than an hour before treatment, are probably
      best treated by:  Syrup of Ipecac, followed by 1-2 glasses of water.
      Dose for adults and children over 12 years:  30 ml.  Dose for children
      under 12 years:  15 ml (25).

           EYE CONTACT:   Flush contaminated eyes with copious amounts of
      fresh water for 15 minutes (25).

      NOTES TO PHYSICIAN:

      INGESTIONS of LARGE amounts (more than 10 mg/kg) occurring less than an
      hour before treatment, should probably be treated by gastric lavage:
      A.   INTUBATE stomach and ASPIRATE contents.
      B.   LAVAGE stomach with slurry of ACTIVATED CHARCOAL in 0.9% saline.
           Leave 30-50 gm activated charcoal in the stomach before
           withdrawing tube.
      C.   SODIUM SULFATE, 0.25 gm/kg in tap water, as a cathartic.
           CAUTION:  Hydrocarbons (kerosene, petroleum distillates) are
                     included in some formulations of these chemicals.
                     Ingestion of very LARGE AMOUNTS may cause CNS
                     depression.  In this case, IPECAC IS CONTRAINDICATED.
                     Also, gastric intubation incurs a risk of HYDROCARBON
                     PNEUMONITIS.  For this reason observe the following
                     precautions:
                     (1)  If the victim is unconscious or obtunded and
                          facilities are at hand, insert an ENDOTRACHEAL TUBE
                          (cuffed, if available) prior to gastric intubation.
                     (2)  Keep victim's HEAD BELOW LEVEL OF STOMACH during
                          intubation and lavage (Trendelenburg, or left
                          lateral decubitus, with head of table tipped
                          downward).  Keep victim's head turned to the left.
                     (3)  ASPIRATE PHARYNX as regularly as possible to remove
                          gagged or vomited stomach contents.
      INGESTIONS occurring MORE THAN an HOUR before treatment are probably
      best treated only by ACTIVATED CHARCOAL, 30-50 gm and SODIUM or
      MAGNESIUM SULFATE, 0.25 gm/kg, as described above.
      There are no specific antidotes for these chemicals.  Because
      manifestations of toxicity do occasionally occur in peculiarly
      predisposed individuals, MAINTAIN CONTACT with victim for at least 72
      hours so that unexpected adverse effects can be treated promptly (25).


                        VI.  FIRE AND EXPLOSION INFORMATION

      GENERAL:  The product is not considered flammable.  It will support
      combustion and may decompose under fire conditions to give off toxic
      materials.  Vapors may be irritating to the respiratory tract and may
      cause breathing difficulty and pulmonary edema.  Symptoms may be
      delayed several hours or longer depending upon exposure.  As in any
      fire, prevent human exposure to fire, smoke, fumes, or products of
      combustion.  Evacuate nonessential personnel from the fire area.  Wear
      full face self contained breathing appratus and impervious clothing
      (such as gloves, hoods, suits and rubber boots) (Folpet 50-WP) (29f).

      EXTINGUISHER TYPE:  Use standard firefighting techniques in
      extinguishing fires involving this product.  High pressure water hose
      may spread product from broken containers increasing contamination
      hazards.  Use of contaminated buildings, areas, and equipment, must be
      prevented until they are properly decontaminated (Folpet 50 WP) (29f).


                                VII.  COMPATIBILITY

           Compatible with most pesticides except strong alkali compounds and
      EC-formulated insecticides.  Do not combine with TEPP.  Should not be
      used in combination with or closely following oil sprays (48).


                            VIII.  PROTECTIVE MEASURES

      STORAGE AND HANDLING:  Containers should be stored in a cool, dry, well
      ventilated area.  Store away from flammable materials and sources of
      heat and flame.  Do not store near seeds, fertilizer or foodstuffs.
      Exercise due caution to prevent damage to or leakage from the container
      (Folpet 50 WP, 29f).

      PROTECTIVE CLOTHING:   Dermal contact and exposure should be minimized
      through the use of gloves and suitable long sleeved clothing.  Eye
      contact should be prevented through the use of chemical safety glasses,
      goggles, or a face shield (Folpet 50 WP, 29f).

      PROTECTIVE EQUIPMENT:  This material should only be handled in open
      areas.  Where adequate ventilation is not available and there is a
      possibility of dust generation, control of inhalation exposure can be
      achieved through the use of NIOSH approved full-face piece, respirator
      (Folpet 50 WP, 29f).


                       IX.  PROCEDURES FOR SPILLS AND LEAKS

                     IN CASE OF EMERGENCY, CALL, DAY OR NIGHT
                                  (800) 424-9300
                      PESTICIDE TEAM SAFETY NETWORK/CHEMTREC

      Make sure all personnel involved in the spill cleanup follow good
      industrial hygiene practices.

      A small spill can be handled routinely.  Use adequate ventilation or
      wear an air supplied respirator to prevent inhalation contact.  Wear
      protective clothing to prevent skin and eye contact.  Use the following
      procedures:

      1.   Sweep up spilled product being careful not to create dust.

      2.   Place the sweepings in an open drum.

      3.   Generously cover the contaminated areas with a common household
           detergent (e.g. Tide).  Using a stiff brush and small amounts of
           water, work the detergent into the spill material forming a
           slurry.  Brush the slurry into cracks and crevices; and allow to
           stand for 2 to 3 minutes.  Be careful to completely avoid skin or
           eye contact; do not splatter on one's self or bystanders.

      4.   Spread absorbents on the slurried liquid, and shovel the absorbed
           material into an open drum.

      5.   Repeat if necessary.

      6.   Flush the area with water, while observing proper environmental
           considerations.

      7.   Seal drum and dispose of contaminated material in an approved
           pesticide dump.

      8.   This product is toxic to fish.  Do not contaminate any body of
           water by cleaning of equipment or disposal of wastes.

      Large spills must be handled according to a predetermined plan.  For
      assistance in developing a plan, contact Stauffer's Agricultural
      Chemical Division, Westport, CT, 06880 (Folpet 50-WP) (29f).


                               X.  LITERATURE CITED

       6.  Farm Chemicals Handbook, 66th ed.  1980.  G. L. Berg, C. Sine,
               S. Meister, and H. Shephard, eds.  Meister Publ. Co.,
               Willoughby, OH.

      25.  Morgan, D.P.  1982.  Recognition and management of
               pesticide poisonings, 3rd ed.  U. S. Environmental Protection
               Agency, Washington, DC.  120 pp.

      26.  The Pesticide Manual:  A World Compendium, 6th ed.  1979.  C. R.
               Worthing, ed.  The British Crop Protection Council, Croydon,
               England.  655 pp.

      29f. Stauffer Chemical Company.  1979.  Product safety information:
               Folpet 50-WP agricultural fungicide (Phaltan).  Westport, CT.

      48.  Harding, W.C.  1979-80.  Pesticide profiles, part two:  fungicides
               and nematicides.  Univ. Maryland, Coop. Ext. Service Bull.
               283, 22 pp.

      56.  Farm Chemicals Handbook, 70th ed.  1984.  R. T. Meister, G. L.
               Berg, C. Sine, S. Meister, and J. Poplyk, eds.  Meister
               Publishing Co., Willoughby, OH.

      1/31/85