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Fosetyl-Al - Chemical Fact Sheet 10/83

                        CHEMICAL FACT SHEET FOR:
                          FOSETYL-AL(ALIETTE)

FACT SHEET NUMBER: 1

DATE ISSUED: OCTOBER 11, 1983

                      1.  DESCRIPTION OF CHEMICAL

- Generic Name:  aluminum tris (O-ethyl phosphonate)
- Common Name:  Fosetyl-Al
- Trade Name:  Aliette
- EPA Shaughnessy Code:  123301
- Chemical Abstracts Service (CAS) Number:  39148-24-8
- Year of Initial Registration:  1983
- Pesticide Type:  Fungicide
- Chemical Family:  Aluminum ester of alkyl phosphonate
- U.S. and Foreign Producers:  Rhone-Poulenc, Incorporated

                     2.  USE PATTERNS AND FORMULATIONS

- Application sites:  greenhouses, field grown ornamentals, and
  pineapple seed pieces
- Types of formulations:  wettable powder
- Types and methods of applications:  dip and ground spray apparatus
- Usual carriers:  water

                           3.  SCIENCE FINDINGS

Chemical Characteristics

- Fosetyl-Al is a fine white, odorless powder.  It is stable to heat,
  melts with decomposition at temperatures greater than 200 degrees C.
  The chemical does not present any unusual handling hazards.

Toxicological Characteristics

- Fosetyl-Al is considered a strong eye irritant (Toxicity Category 1)
- It demonstrates low toxicity from oral, dermal and inhalation routes
  of exposure (Toxicity Category IV, III, & III respectively).
- The chemical is not considered to be a skin irritant.
- Toxicology studies on Fosetyl-Al are as follows:
- Oral LD50 in rats:  5.4 gm/kg body weight
- Dermal LD50 in rats:  >3 gm/kg
- Inhalation LC50 in rats:  >1.73 mg/l
- Eye irritation in rabbits:  2/6 animals revealed pannus of the
  cornea at 7 days and continued to show irritating effects at 21
  days
- Dermal irritation in rabbits:  not an irritant
- Skin sensitization in guinea pigs:  not a skin sensitizer
- Teratology in rabbits:  No observable effect level (NOEL) > 500
  mg/kg/day
- Teratology in rats: NOEL > 1000 mg/kg/day
- Multi-generation reproduction study in rats: The reproduction NOEL
  is 6000 parts per million (PPM); the lowest effect level (LEL) is
  12,000 ppm (crystalline deposits in urogenital system, lower
  overall weight pains in the F2b generation, lower litter mean
  pup weights in late lactation).
- Chronic feeding/oncogenicity in rats: The chronic
  feeding/oncogenicity NOEL is 8000 ppm; the LEL is 3000/4000 ppm
  (calculi and mineralization in 14/79 males in urogenital).
- Chronic feeding in dogs: The chronic feeding NOEL is 10,000 ppm;
  the LEL is 20,000 ppm (presence of spermatocytic and/or
  spermatidic giant cells within the semineferous tubules).
- Oncogenicity in mice: No oncogenic effects were induced at any
  dose level under conditions of this test (highest dose tested
  20,000/30,000 ppm).
- Mutagenicity: Fosetyl-Al did not show any mutagenic activity in
  gene mutation, chromosomal aberration, or micronucleus tests.

Environmental Characteristics

- The degradation of Fosetyl-Al in soil under aerobic conditions is
  quite rapid and is due to microbial action. Half-life is 1 to 1/2
  hours in loamy sand, silt loam, and clay loam soils. and 20 minutes
  in sandy loam soil. The degradation proceeds through the hydrolysis
  of the ethyl ester bond, resulting in the formation of phosphorous
  acid and ethanol. The ethanol is further degraded into carbon
  dioxide. The phosphorous acid formed will form precipitates with
  calcium, aluminum. or iron in the soil, or with aluminum from the
  Fosetyl-Al.
- Under field conditions, the chemical is not expected to leach.
- Bioaccumulation does not appear to be a factor.
- The use patterns are not expected to result in direct contamination
  hazards (via spray drift) to humans, livestock, or wildlife outside
  the application sites.

Ecological Characteristics

- Avian oral LD50:  >8000 mg/kg (extremely low toxicity)
- Avian dietary LC50:  >20,000 ppm
- Fish LC50:  >150 mg/l (low toxicity)
- Aquatic invertebrate LC50:  189 ppm
- The use patterns of the chemical do not present any problem to
  endangered species.

Tolerance Assessment

- A tolerance of 0.1 ppm is required for pineapples and pineapple
  forage.  Data developed with C14 labeled Fosetyl-Al indicate that
  residues of Fosetyl-Al or its metabolites could remain in harvested
  pineapples at or below the level of analytical method detection.

Summary Science Statement

- There are no extensive data gaps that exist for Fosetyl-Al.  The
  toxicity from oral, dermal, and inhalation routes of exposure is
  low. The chemical has been demonstrated to be a strong eye irritant.
  The chemical is considered to be an oncogen. Available data indicate
  that Fosetyl-Al has no teratogenic potential nor is it a mutagen.
- Fosetyl-Al is degrated rapidly in both moist and dry soils under
  aerobic conditions, with half-lives 1 to 1/2 half hours and 20
  minutes respectively.  The chemical is not expected to contaminate
  groundwater.
- Fosetyl-Al has a low toxicity for both fish and wildlife, and the
  chemical and its use patterns presents no problems to endangered
  species.

           4.  SUMMARY OF REGULATORY POSITION AND RATIONALE

- General use
- No use, formulation, or geographical restrictions are required
- Because of oncogenicity potential of this compound, a risk assessment
  was calculated for all uses involved.  The risk calculations are based
  on overestimates of any actual risk exposure.  The calculated risks,
  although low, are likely to be overestimates.
- Dietary risk for pineapples is 0.27-2.40 x 10-8
- Oncogenic risk exposure ranged from 1.0-9.0 x 10-9 to applicators to
  0.7-6.0 x 10-6 for pineapple planters wearing gloves.
- For the pineapple use, the following statement is required to reduce
  the exposure to seed piece planters:  Note to User:  Gloves
  impermeable to Fosetyl-Al must be worn during the handling and
  planting of pineapple crowns (seed pieces).

                  5.  SUMMARY OF MAJOR DATA GAPS

Exposure monitoring study for pineapple seed piece treaters.

                     6.  CONTACT PERSON AT EPA

Henry M. Jacoby
EPA (TS-767C)
401 M St., S.W.
Washington, DC  20460
(703) 557-1900

DISCLAIMER:  THE INFORMATION PRESENTED IN THIS CHEMICAL INFORMATION FACT
SHEET IS FOR INFORMATIONAL PURPOSES ONLY AND NOT TO BE USED TO FULFILL
DATA REQUIREMENTS FOR PESTICIDE REGISTRATION AND REREGISTRATION.