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Thiabendazole (Arbotect, Mertect) - Chemical Profile 2/85

                                   thiabendazole

      CHEMICAL name:      2-(4'-Thiazolyl)-benzimidazole (56)

      TRADE name(S):      Arbotect, Mertect, TBZ, Tecto, Thibenzole, Apl-
                          Luster (56)

      FORMULATION(S):     Wettable powder 60%, 45% flowable, smoke generator
                          (56)

      TYPE:               Benzimidazole fungicide

      BASIC PRODUCER(S):  Merck and Co., Inc.
                          MSD Agvet Div.
                          P.O. Box 2000
                          123 E. Lincoln Ave.
                          Rahway, NJ 07065

      STATUS:             General use

      PRINCIPAL USES:  Preventative and eradicant chemical against molds,
      rots and others on vegetables, turf and ornamentals.  Some systemic
      action.  Used orally on humans and livestock for roundworm control
      (48).
           Fungicide to control green mold, blue mold, and stem end rot of
      citrus fruits; to control Cercospora leaf spot on sugar beets; to
      control Fusarium basal rot and Penicillium blue mold on ornamental
      bulbs and corms; to control brown rot on bananas; to control blue mold
      rot, bull's eye rot and gray mold on apples and pears; to control
      black rot, scurf and foot rot of sweet potatoes; to control Fusarium
      (dry rot) in potato storage.  Also as a preservative for reconstituted
      tobacco.  On soybeans to reduce the severity of pod and stem blight,
      anthracnose, brown spot, frog eye leaf spot, and purple seed stain.
      Antihelmintic to treat cattle against roundworm infestations, sheep and
      goats for roundworm infestations, swine for prevention of infestation
      by large roundworms (Ascaris) (56).

                                   I.  EFFICACY

           Pathogenic fungi controlled include species of Aspergillus,
      Botrytis, Ceratocystis, Cercospora, Colletotrichum, Diaporthe,
      Fusarium, Giberella, Gloesporium, Oospora, Penicillium, Phoma,
      Rhizoctonia, Sclerotinia, Septoria, and Verticillium (26).
           It has been demonstrated that considerable thiabendazole persists
      in the plant for 2-3 weeks after absorption (51a).

                             II.  PHYSICAL PROPERTIES

      MOLECULAR FORMULA:  C10 H7 N3 S (26)

      MOLECULAR WEIGHT:   201.2 (26)

      PHYSICAL STATE:     Colorless powder (pure compuond) (26)

      MELTING POINT:      304-305 C (pure compound) (26)

      VAPOR PRESSURE:     Nonvolatile at room temperature but sublimes when
                          heated strongly to 310 C (pure compound) (26)

      SOLUBILITY:         c. 10 g/l water at pH 2, 25 C; <50 mg/l water at pH
                          5-12, 25 C; >50 mg/l water at pH 12, 25 C (pure
                          compound) (26).

                          III.  HEALTH HAZARD INFORMATION

      OSHA STANDARD:  NA

      NIOSH RECOMMENDED LIMIT:  NA

      ACGIH RECOMMENDED LIMIT:  NA

      TOXICOLOGY

           A.  ACUTE TOXICITY

               ORAL:  LD50 = 3300 mg ai/kg (rat); 3850 mg/kg ai/kg
                      (rabbit) (26).

               EYES:  Irritation studies by application to rabbit's eye
                      revealed only a slight erythema of a short duration
                      when thiabendazol was applied as a dry powder (51a).

           B.  SUBACUTE AND CHRONIC TOXICITY:

           No observable clinical effect followed chronic inhalation at 70
      mg/m3.  In 2-year feeding trials rats receving 40 mg/kg daily showed no
      evidence of ill-effect (26).
           No evidence of teratogenesis was obtained in a study with rats.
      Subacute inhalation studies demonstrated that thiabendazole has a very
      low order of subacute toxicity (51a).

                        IV.  ENVIRONMENTAL  CONSIDERATIONS

           Nonhazardous to wildlife.  Nonphytotoxic when used as directed
      (48).
           In mammals, thiabendazole metabolites have been found to be
      5-hydroxy-thiabendazole and its glucuronide and sulfate conjugates
      (51a).

                      V.  EMERGENCY AND FIRST AID PROCEDURES

           The chemical information provided below has been condensed
      from original source documents, primarily from "Recognition and
      Management of Pesticide Poisonings", 3rd ed. by Donald P.  Morgan,
      which have been footnoted.  This information has been provided in
      this form for your convenience and general guidance only.  In
      specific cases, further consultation and reference may be required
      and is recommended.  This information is not intended as a sub-
      stitute for a more exhaustive review of the literature nor for the
      judgement of a physician or other trained professional.

           If poisoning is suspected, do not wait for symptoms to develop.
      Contact a physician, the nearest hospital, or the nearest Poison
      Control Center.

           To be developed.

                         VI.  FIRE AND EXPLOSION INFORMATION

           To be developed.

                                VII.  COMPATIBILITY

           Incompatible with a number of other pesticides, especially copper
      compounds and those alkaline in reaction (48).

                            VIII.  PROTECTIVE MEASURES

           To be developed.

                       IX.  PROCEDURES FOR SPILLS AND LEAKS

                     IN CASE OF EMERGENCY, CALL, DAY OR NIGHT
                                  (800) 424-9300
                      PESTICIDE TEAM SAFETY NETWORK/CHEMTREC

                               X.  LITERATURE CITED

      26.  The Pesticide Manual:  A World Compendium, 6th ed.  1979.  C. R.
               Worthing, ed.  The British Crop Protection Council, Croydon,
               England.  655 pp.

      48.  Harding, W.C.  1979-80.  Pesticide profiles, part two:  fungicides
               and nematicides.  Univ. Maryland, Coop. Ext. Service Bull.
               283, 22 pp.

      51a. Merck, Sharp and Dohme, Canada Ltd.  1970.  Summary data sheet
               1970-73 for thiabendazole, a new experimental fungicide.
               Quebec, Canada.

      56.  Farm Chemicals Handbook, 70th ed.  1984.  R. T. Meister, G. L.

               Berg, C. Sine, S. Meister, and J. Poplyk, eds.  Meister
               Publishing Co., Willoughby, OH.

      2/5/85