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thiophanate-methyl (Topsin M) Chemical Profile 2/85

                                 thiophanate-methyl

      CHEMICAL NAME:      Dimethyl [(1,2-phenylene)bis-(iminocarbonothioyl)]
                          bis [carbamate] (56)

      TRADE NAME(S):      Topsin M, Fungo, Cercobin-M (48)

      FORMULATION(S):     Wettable powder 70%, paste 3%, flowable 50%,
                          flowable 4 pounds/gallon, dust 5%, ULV 50% (56).

      TYPE:               Organic fungicide

      BASIC PRODUCER(S):  Pennwalt Corp.
                          Agchem Div.
                          1630 East Shaw Ave., Suite 179
                          Fresno, CA 93710

      STATUS:  General use.  RPAR; criteria possibly met or
      exceeded:  mutagenicity, reduction in non-target species (rebutted).
      PD 1 published 12/7/77; comment period closed 3/27/78.  PD 2 completed
      and Notice of Proposed Determination published, 10/11/79.  PD 4
      completed and Notice of Determination published 10/20/82.  That
      determination which included benomyl, required use of protective
      clothing and generation of additional data.  Registration Standards
      Development Program (22).

      PRINCIPAL USES:  Curative, preventive and systemic chemical against
      broad spectrum of plant diseases on fruits, vegetables, turf and
      certain other crops (48).


                                   I.  EFFICACY

           Some control of nematodes has been observed.  Strains resistant to
      benomyl are usually resistant to this fungicide (48).
           Effective against a wide range of fungal pathogens including:
      Venturia spp. on apples and pears; powdery mildews (Podosphaera sp.,
      Erysiphe spp. and Sphaerotheca fuliginea) on apples, pears, small
      grains, vines and cucurbits; leaf spot diseases caused by Cercospora
      spp., Botrytis spp. and Sclerotinia spp. on various crops (26).
          Shows curative effect (6).
          Gives long residual control (48).


                             II.  PHYSICAL PROPERTIES

      MOLECULAR FORMULA:  C12 H14 N4 O4 S2 (26)

      MOLECULAR WEIGHT:   342.4 (26)

      PHYSICAL STATE:     Stable colorless crystalline solid (pure compound)
                          (26); technical product at least 96% a.i (56).

      MELTING POINT:      172 C (decomposes, pure compound) (26)

      SOLUBILITY:         Very low solubility in water (pure compound) (26)


                          III.  HEALTH HAZARD INFORMATION

      OSHA STANDARD:  NA

      NIOSH RECOMMENDED LIMIT:  NA

      ACGIH RECOMMENDED LIMIT:  NA

      TOXICOLOGY

           A.  ACUTE TOXICITY

               DERMAL:  LD50 = >10,000 mg/kg (mice, rats, guinea pigs and
                        rabbits) (26).

               ORAL:    LD50 = 7,500 mg/kg (rat) (56)

           B.  SUBACUTE AND CHRONIC TOXICITY:

           To be developed.

                       IV.  ENVIRONMENTAL  CONSIDERATIONS

           Some hazard to fish and wildlife.  Nonphytotoxic when used as
      directed (48).


                      V.  EMERGENCY AND FIRST AID PROCEDURES

           The chemical information provided below has been condensed
      from original source documents, primarily from "Recognition and
      Management of Pesticide Poisonings", 3rd ed. by Donald P.  Morgan,
      which have been footnoted.  This information has been provided in
      this form for your convenience and general guidance only.  In
      specific cases, further consultation and reference may be required
      and is recommended.  This information is not intended as a sub-
      stitute for a more exhaustive review of the literature nor for the
      judgement of a physician or other trained professional.

           If poisoning is suspected, do not wait for symptoms to develop.
      Contact a physician, the nearest hospital, or the nearest Poison
      Control Center.

           To be developed.


                        VI.  FIRE AND EXPLOSION INFORMATION

           To be developed.


                                VII.  COMPATIBILITY

           Incompatible with pesticides alkaline in reaction or copper
      compounds (48).


                            VIII.  PROTECTIVE MEASURES

      STORAGE AND HANDLING:  Store in a cool, dry place, away from feed and
      foodstuffs.  Avoid contact with mouth, eyes, and skin.  Keep out of
      reach of children (56).

      PROTECTIVE CLOTHING:  Rubber gloves, respirator, rubber boots, long-
      sleeved shirt/jacket and long pants (56).


                       IX.  PROCEDURES FOR SPILLS AND LEAKS

                     IN CASE OF EMERGENCY, CALL, DAY OR NIGHT
                                  (800) 424-9300
                      PESTICIDE TEAM SAFETY NETWORK/CHEMTREC


                               X.  LITERATURE CITED

      22.  U.S. Environmental Protection Agency, Office of Pesticide
               Programs.  1983.  June 1983 status report on rebuttable
               presumption against registration (RPAR) or special review
               process, registration standards and the data call in
               programs.  Washington, DC.  45 pp.

      26.  The Pesticide Manual:  A World Compendium, 6th ed.  1979.  C. R.
               Worthing, ed.  The British Crop Protection Council, Croydon,
               England.  655 pp.

      48.  Harding, W.C.  1979-80.  Pesticide profiles, part two:  fungicides
               and nematicides.  Univ. Maryland, Coop. Ext. Service Bull.
               283, 22 pp.

      56.  Farm Chemicals Handbook, 70th ed.  1984.  R. T. Meister, G. L.
               Berg, C. Sine, S. Meister, and J. Poplyk, eds.  Meister
               Publishing Co., Willoughby, OH.

      2/5/85