thiophanate-methyl (Topsin M) Chemical Profile 2/85
CHEMICAL NAME: Dimethyl [(1,2-phenylene)bis-(iminocarbonothioyl)]
bis [carbamate] (56)
TRADE NAME(S): Topsin M, Fungo, Cercobin-M (48)
FORMULATION(S): Wettable powder 70%, paste 3%, flowable 50%,
flowable 4 pounds/gallon, dust 5%, ULV 50% (56).
TYPE: Organic fungicide
BASIC PRODUCER(S): Pennwalt Corp.
1630 East Shaw Ave., Suite 179
Fresno, CA 93710
STATUS: General use. RPAR; criteria possibly met or
exceeded: mutagenicity, reduction in non-target species (rebutted).
PD 1 published 12/7/77; comment period closed 3/27/78. PD 2 completed
and Notice of Proposed Determination published, 10/11/79. PD 4
completed and Notice of Determination published 10/20/82. That
determination which included benomyl, required use of protective
clothing and generation of additional data. Registration Standards
Development Program (22).
PRINCIPAL USES: Curative, preventive and systemic chemical against
broad spectrum of plant diseases on fruits, vegetables, turf and
certain other crops (48).
Some control of nematodes has been observed. Strains resistant to
benomyl are usually resistant to this fungicide (48).
Effective against a wide range of fungal pathogens including:
Venturia spp. on apples and pears; powdery mildews (Podosphaera sp.,
Erysiphe spp. and Sphaerotheca fuliginea) on apples, pears, small
grains, vines and cucurbits; leaf spot diseases caused by Cercospora
spp., Botrytis spp. and Sclerotinia spp. on various crops (26).
Shows curative effect (6).
Gives long residual control (48).
II. PHYSICAL PROPERTIES
MOLECULAR FORMULA: C12 H14 N4 O4 S2 (26)
MOLECULAR WEIGHT: 342.4 (26)
PHYSICAL STATE: Stable colorless crystalline solid (pure compound)
(26); technical product at least 96% a.i (56).
MELTING POINT: 172 C (decomposes, pure compound) (26)
SOLUBILITY: Very low solubility in water (pure compound) (26)
III. HEALTH HAZARD INFORMATION
OSHA STANDARD: NA
NIOSH RECOMMENDED LIMIT: NA
ACGIH RECOMMENDED LIMIT: NA
A. ACUTE TOXICITY
DERMAL: LD50 = >10,000 mg/kg (mice, rats, guinea pigs and
ORAL: LD50 = 7,500 mg/kg (rat) (56)
B. SUBACUTE AND CHRONIC TOXICITY:
To be developed.
IV. ENVIRONMENTAL CONSIDERATIONS
Some hazard to fish and wildlife. Nonphytotoxic when used as
V. EMERGENCY AND FIRST AID PROCEDURES
The chemical information provided below has been condensed
from original source documents, primarily from "Recognition and
Management of Pesticide Poisonings", 3rd ed. by Donald P. Morgan,
which have been footnoted. This information has been provided in
this form for your convenience and general guidance only. In
specific cases, further consultation and reference may be required
and is recommended. This information is not intended as a sub-
stitute for a more exhaustive review of the literature nor for the
judgement of a physician or other trained professional.
If poisoning is suspected, do not wait for symptoms to develop.
Contact a physician, the nearest hospital, or the nearest Poison
To be developed.
VI. FIRE AND EXPLOSION INFORMATION
To be developed.
Incompatible with pesticides alkaline in reaction or copper
VIII. PROTECTIVE MEASURES
STORAGE AND HANDLING: Store in a cool, dry place, away from feed and
foodstuffs. Avoid contact with mouth, eyes, and skin. Keep out of
reach of children (56).
PROTECTIVE CLOTHING: Rubber gloves, respirator, rubber boots, long-
sleeved shirt/jacket and long pants (56).
IX. PROCEDURES FOR SPILLS AND LEAKS
IN CASE OF EMERGENCY, CALL, DAY OR NIGHT
PESTICIDE TEAM SAFETY NETWORK/CHEMTREC
X. LITERATURE CITED
22. U.S. Environmental Protection Agency, Office of Pesticide
Programs. 1983. June 1983 status report on rebuttable
presumption against registration (RPAR) or special review
process, registration standards and the data call in
programs. Washington, DC. 45 pp.
26. The Pesticide Manual: A World Compendium, 6th ed. 1979. C. R.
Worthing, ed. The British Crop Protection Council, Croydon,
England. 655 pp.
48. Harding, W.C. 1979-80. Pesticide profiles, part two: fungicides
and nematicides. Univ. Maryland, Coop. Ext. Service Bull.
283, 22 pp.
56. Farm Chemicals Handbook, 70th ed. 1984. R. T. Meister, G. L.
Berg, C. Sine, S. Meister, and J. Poplyk, eds. Meister
Publishing Co., Willoughby, OH.