PMEP Home Page --> Pesticide Active Ingredient Information --> Fungicides and Nematicides --> TCMTB (Busan) to zoxamide --> triflumizole (Terraguard, Procure) --> triflumizole (Terraguard, Procure) Registration 8/95

triflumizole (Terraguard, Procure) Registration 8/95

August 3, 1995

Ms. Judith Ball
Uniroyal Chemical Company, Inc.
74 Amity Road
Bethany, CT  06524-3402

Dear Ms. Ball:


Re:  Registration of Terraguard 50W (EPA Reg. No. 400-433) containing 
the New Active Ingredient Triflumizole

The New York State Department of Environmental Conservation has accepted 
your application to register the pesticide product Terraguard 50W 
Fungicide for use as a protectant soak, soil drench, foliar spray or 
through chemigation for control of certain diseases on ornamentals grown 
in enclosed commercial structures such as greenhouses, shadehouses, 
nurseries, and interiorscapes.

Terraguard 50W contains 50% of the new active ingredient Triflumizole 
(chemical name: 1-[1-[[4-chloro-2-(trifluoromethyl)phenyl]imino]-2-
propoxyethyl]-H-imidazole).  It may be applied weekly or biweekly as 
needed, at a single rate of 16 oz/100 gallons of water, or 1 lb active 
ingredient/acre with 12 to 24 applications per year.

The data package was submitted for review to the Division of Water 
(DOW), the Division of Fish and Wildlife (DF&W), and the New York State 
Department of Health (NYSDOH).

The Bureau of Environmental Protection, DF&W has reviewed the data 
package and determined that the labelled indoor uses of Terraguard 50W 
should not adversely impact the fish and wildlife resources of New York 
State.

The DOW, in its review, has concluded that labelled use of Terraguard 
50W in New York State is unlikely to result in significant impacts to 
groundwater resources.  The active ingredient degrades rapidly relative 
to other compounds and does not appear to have a high propensity to 
leach.

The NYSDOH has stated in their review that in acute animal studies 
triflumazole was not very toxic by the oral, dermal and inhalation 
routes.  However, triflumazole caused severe eye irritation in rabbits 
and mild dermal sensitization in guinea pigs.  Triflumazole does not 
appear to have oncogenic potential, is not very persistent, and does not 
bioaccumulate greatly.  While some reproductive effects were noted, the 
annual average daily exposure for workers is expected to be more than 
900 times lower than the RfD for triflumazole.

The proposed label for Terraguard 50W requires that applictors and other 
handlers wear protective clothing (including eyewear) and risks to 
workers are expected to be low.  Therefore, DOH does not object to the 
registration of Terraguard 50W in New York State

Enclosed are your certificate of registration and stamped accepted label 
for your files.

If you have any questions on this matter, please contact Maureen 
Serafini, Supervisor of our Pesticide Product Registration Section, at 
(518) 457-7446.

Sincerely,

Norman H. Nosenchuck, P.E.
Director
Division of Hazardous Substances Regulation