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butylate (Sutan, Sutan+) Herbicide Profile 3/84

                   CHEMICAL FACT SHEET FOR BUTYLATE
FACT SHEET NUMBER:  07
DATE ISSUED:  MARCH 22, 1984
                      1. DESCRIPTION OF CHEMICAL
- Generic Name:  Butylate 
- Common Name:  butylate 
- Trade Name:  Sutan 
- EPA Shaughnessy Code:  041405 
- Chemical Abstracts Service (CAS) Number:  2008-41-5 
- Year of Initial Registration:  1967 
- Pesticide Type:  Herbicide 
- Chemical Family:  Thiocarbamate 
- U.S. and Foreign Producers:  Stauffer Chemical Company,
  PPG Industries, Inc.
                    2. USE PATTERNS AND FORMULATIONS
- Application sites:  Sweet corn, field corn, and popcorn 
- Types of formulations:  Granulars, emulsifiable concentrates, and
  encapsulated 
- Types and methods of application:  Soil incorporation, generally with
  disks or hooded power-driven tillers, often in combination with
  atrazine and/or cyanazine herbicide. Center pivot irrigation systems
  can be used in some areas. 
- Application rates:  3.4-6.7 lbs ai/A 
- Usual carriers:  Emulsifiable liquid formulations are diluted 
  in water.
                           3. SCIENCE FINDINGS
Chemical Characteristics:
- Physical state:  liquid 
- Color:  yellow to amber 
- Odor:  amine 
- Boiling point:  71 degrees C at 10 mm Hg 
- Melting point:  not applicable 
- Flash point:  (TOC) 110 degrees C 
- Unusual handling characteristics:   None. Non-corrosive, stable at
  normal ambient temps.
Toxicological Characteristics:
Acute Effects:
- Acute oral LD50:  low - (Tox Category III) (3.0 g/kg)
- Acute dermal LD50:  low - (Tox Category III) (>2 g/kg)
- Dermal irritation:  not an irritant
- Acute inhalation toxicity:  data gap
- Primary eye irritation:  caused permanent damage in 1/6 of unwashed
  eyes (Tox Category II)
Chronic Effects: 
- Oncogenicity:  No dose-related effects at levels up to 320 mg/kg/day
  (HDT) (Highest Dose Tested) in a 24-month study. 
- Teratology:  No effects at up to 24 mg/kg (HDT). 
- Reproductive effects:  No effects at up to 24 mg/kg (HDT). 
- Mutagenicity:  data gap 
- Feeding studies:  13-week study with dogs: No effects on behavior or
  bodyweight. No neurological opthalmological, hematological, or blood
  chemistry effects. No effect on brain AChE, gross organ appearance, or
  weight. Fifty-six week study with rats: No major effects at 10 and 30
  mg/kg. HDT 180 mg/kg produced liver pericholagitis, uterine and
  testicular changes with focal hemorrhage. Blood clotting parameters
  were affected at lowest dose (10 mg/kg/day).
- Major Routes of Exposure: Dermal, inhalation
Physiological and Biochemical Behavioral Characteristics:
- Foliar absorption:  Absorbed by leaves, but not normally applied to
  the foliage.
- Translocation:  Butylate is rapidly absorbed by the roots of the corn
  plant and translocated throughout the whole corn plant.
- Mechanism of pesticidal action:  Unknown. Inhibits growth in the
  meristemic region of the leaves of grassy weeds.
- Metabolism and persistence in plants and animals:  Metabolized rapidly
  to C02, diisobutylamine, fatty acids, conjugates of amines and fatty
  acids, and certain natural plant constituents. Disappears from the
  stems and leaves of corn plants 7 to 14 days after treatment.
Environmental Characteristics:
- Adsorption and leaching in basic soil types:  In sandy dry soils,
  butylate leached about one-third the distance that 20 cm (8 inches) of
  water moved. Leaching decreased as clay and organic matter increased.
  In heavy clay soils, butylate leached slightly downward 2.5 to 7.6 cm
  (1 to 3 inches) with 20 cm of water.
- Microbial breakdown: Microbial breakdown plays an important role in
  the disappearance of butylate from soils.
- Loss from photodecomposition and/or volatilization: Butylate is lost
  by vaporization when applied to the surface of wet soils without
  incorporation. Very little loss occurs after application to dry soil
  surfaces.
- Bioaccumulation:  Butylate has moderate potential for bioaccumulation
  in fish. After 28 days of exposure, bluegill sunfish had
  bioaccumulation ratios of 33X ambient in edible tissues, and 119-174X
  ambient in non-edible tissues.
- Resultant average persistence:  The half-life of butylate under crop
  growing conditions was 1.5 to 3 weeks in several soils. In a loam
  soil at 21 to 27 degrees C (70 to 80 degrees F), the half-life was 
  3 weeks.
- Half-life in Water:  Data not yet available.
Ecological Characteristics:
- Hazards to Birds:  Minimal, owing to low toxicity and low exposure
  rates 
- Hazards to Aquatic Invertebrates:  Minimal, owing to moderate toxicity
  and low exposure rates 
- Hazards to Fish:  Not fully assessed yet. Butylate is at least
  moderately toxic to fish, but requested data might show a greater
  toxicity. If earlier studies prove accurate, and butylate is only
  moderately toxic to fish, the hazards to fish from the registered use
  patterns are low.
- Potential Problems with Endangered Species:  None anticipated
Tolerance Assessment:
- List of crops and tolerances:  Corn grain (including popcorn), fresh
  corn (including sweet corn - kernels plus cob with husk removed), and
  corn forage and fodder (including sweet corn, field corn, and popcorn)
  at 0.1 ppm. 
- List of food contact uses:  All corn products listed above. 
- Results of tolerance assessment:  Assuming 100% of all corn products
  to be treated with butylate, the dietary burden amounts to no more
  than .032% of the ADI. Reassessment has been conducted. No tolerance
  changes are needed at this time.
Problems Known to Have Occurred From Use:
     None
Summary Science Statement:
     Butylate appears to pose few, if any, acute toxicological hazards 
to humans or non-target wildlife. The only major concern is the lack of 
inhalation toxicity data. Such data has been requested in the standard.
             4. SUMMARY OF REGULATORY POSITION AND RATIONALE
- Use classification: General use classification.
- Use, formulation, or geographic restrictions:  Uses are limited to
  application to corn fields. No other restrictions.
- Unique label warning statements: 
  - Manufacturing Use Products:
    - Do not discharge into lakes, streams, ponds, or public waters
      unless in accordance with an NPDES permit. For guidance, contact
      your regional office of the EPA. 
- End-Use Products: 
  - Harmful if swallowed. Avoid contact with skin, eyes, and clothing.
    Avoid breathing spray mist. Wear goggles, rubber gloves, and
    protective clothing. Wash skin with soap and water immediately after
    contact. Flush eyes with water.
  - Do not apply directly to water or wetlands. Do not contaminate water
    by cleaning of equipment or disposal of wastes. Cover or incorporate
    spills. 
- Data gaps exist (see below), but the Agency will not cancel or
  withhold registration solely because of data gaps. The available
  toxicity and environmental fate data indicate that butylate use is
  unlikely to cause severe hazards to humans or wildlife; and although
  this analysis of hazard cannot be considered complete until the data
  gaps are filled, there is sufficient justification for continuing the
  registration of butylate products.
                      5. SUMMARY OF MAJOR DATA GAPS
     An inhalation LC50 for rats is needed, and has been required. Other 
data gaps exist, but none is considered major, or as important as the 
lack of an inhalation LC50. The inhalation LC50 is to be supplied by 
April, 1985. The mutagenicity data and other data are to be supplied by 
October, 1987.
                         6. CONTACT PERSON AT EPA
Robert Taylor
T5-767C
401 M Street SW
Washington, DC 20460
(703) 557-1800
DISCLAIMER:  THE INFORMATION PRESENTED IN THIS CHEMICAL INFORMATION FACT 
SHEET IS FOR INFORMATIONAL PURPOSES ONLY AND NOT TO BE USED TO FULFILL
DATA REQUIREMENTS FOR PESTICIDE REGISTRATION AND REREGISTRATION.