butylate (Sutan, Sutan+) Herbicide Profile 3/84
CHEMICAL FACT SHEET FOR BUTYLATE
FACT SHEET NUMBER: 07
DATE ISSUED: MARCH 22, 1984
1. DESCRIPTION OF CHEMICAL
- Generic Name: Butylate
- Common Name: butylate
- Trade Name: Sutan
- EPA Shaughnessy Code: 041405
- Chemical Abstracts Service (CAS) Number: 2008-41-5
- Year of Initial Registration: 1967
- Pesticide Type: Herbicide
- Chemical Family: Thiocarbamate
- U.S. and Foreign Producers: Stauffer Chemical Company,
PPG Industries, Inc.
2. USE PATTERNS AND FORMULATIONS
- Application sites: Sweet corn, field corn, and popcorn
- Types of formulations: Granulars, emulsifiable concentrates, and
- Types and methods of application: Soil incorporation, generally with
disks or hooded power-driven tillers, often in combination with
atrazine and/or cyanazine herbicide. Center pivot irrigation systems
can be used in some areas.
- Application rates: 3.4-6.7 lbs ai/A
- Usual carriers: Emulsifiable liquid formulations are diluted
3. SCIENCE FINDINGS
- Physical state: liquid
- Color: yellow to amber
- Odor: amine
- Boiling point: 71 degrees C at 10 mm Hg
- Melting point: not applicable
- Flash point: (TOC) 110 degrees C
- Unusual handling characteristics: None. Non-corrosive, stable at
normal ambient temps.
- Acute oral LD50: low - (Tox Category III) (3.0 g/kg)
- Acute dermal LD50: low - (Tox Category III) (>2 g/kg)
- Dermal irritation: not an irritant
- Acute inhalation toxicity: data gap
- Primary eye irritation: caused permanent damage in 1/6 of unwashed
eyes (Tox Category II)
- Oncogenicity: No dose-related effects at levels up to 320 mg/kg/day
(HDT) (Highest Dose Tested) in a 24-month study.
- Teratology: No effects at up to 24 mg/kg (HDT).
- Reproductive effects: No effects at up to 24 mg/kg (HDT).
- Mutagenicity: data gap
- Feeding studies: 13-week study with dogs: No effects on behavior or
bodyweight. No neurological opthalmological, hematological, or blood
chemistry effects. No effect on brain AChE, gross organ appearance, or
weight. Fifty-six week study with rats: No major effects at 10 and 30
mg/kg. HDT 180 mg/kg produced liver pericholagitis, uterine and
testicular changes with focal hemorrhage. Blood clotting parameters
were affected at lowest dose (10 mg/kg/day).
- Major Routes of Exposure: Dermal, inhalation
Physiological and Biochemical Behavioral Characteristics:
- Foliar absorption: Absorbed by leaves, but not normally applied to
- Translocation: Butylate is rapidly absorbed by the roots of the corn
plant and translocated throughout the whole corn plant.
- Mechanism of pesticidal action: Unknown. Inhibits growth in the
meristemic region of the leaves of grassy weeds.
- Metabolism and persistence in plants and animals: Metabolized rapidly
to C02, diisobutylamine, fatty acids, conjugates of amines and fatty
acids, and certain natural plant constituents. Disappears from the
stems and leaves of corn plants 7 to 14 days after treatment.
- Adsorption and leaching in basic soil types: In sandy dry soils,
butylate leached about one-third the distance that 20 cm (8 inches) of
water moved. Leaching decreased as clay and organic matter increased.
In heavy clay soils, butylate leached slightly downward 2.5 to 7.6 cm
(1 to 3 inches) with 20 cm of water.
- Microbial breakdown: Microbial breakdown plays an important role in
the disappearance of butylate from soils.
- Loss from photodecomposition and/or volatilization: Butylate is lost
by vaporization when applied to the surface of wet soils without
incorporation. Very little loss occurs after application to dry soil
- Bioaccumulation: Butylate has moderate potential for bioaccumulation
in fish. After 28 days of exposure, bluegill sunfish had
bioaccumulation ratios of 33X ambient in edible tissues, and 119-174X
ambient in non-edible tissues.
- Resultant average persistence: The half-life of butylate under crop
growing conditions was 1.5 to 3 weeks in several soils. In a loam
soil at 21 to 27 degrees C (70 to 80 degrees F), the half-life was
- Half-life in Water: Data not yet available.
- Hazards to Birds: Minimal, owing to low toxicity and low exposure
- Hazards to Aquatic Invertebrates: Minimal, owing to moderate toxicity
and low exposure rates
- Hazards to Fish: Not fully assessed yet. Butylate is at least
moderately toxic to fish, but requested data might show a greater
toxicity. If earlier studies prove accurate, and butylate is only
moderately toxic to fish, the hazards to fish from the registered use
patterns are low.
- Potential Problems with Endangered Species: None anticipated
- List of crops and tolerances: Corn grain (including popcorn), fresh
corn (including sweet corn - kernels plus cob with husk removed), and
corn forage and fodder (including sweet corn, field corn, and popcorn)
at 0.1 ppm.
- List of food contact uses: All corn products listed above.
- Results of tolerance assessment: Assuming 100% of all corn products
to be treated with butylate, the dietary burden amounts to no more
than .032% of the ADI. Reassessment has been conducted. No tolerance
changes are needed at this time.
Problems Known to Have Occurred From Use:
Summary Science Statement:
Butylate appears to pose few, if any, acute toxicological hazards
to humans or non-target wildlife. The only major concern is the lack of
inhalation toxicity data. Such data has been requested in the standard.
4. SUMMARY OF REGULATORY POSITION AND RATIONALE
- Use classification: General use classification.
- Use, formulation, or geographic restrictions: Uses are limited to
application to corn fields. No other restrictions.
- Unique label warning statements:
- Manufacturing Use Products:
- Do not discharge into lakes, streams, ponds, or public waters
unless in accordance with an NPDES permit. For guidance, contact
your regional office of the EPA.
- End-Use Products:
- Harmful if swallowed. Avoid contact with skin, eyes, and clothing.
Avoid breathing spray mist. Wear goggles, rubber gloves, and
protective clothing. Wash skin with soap and water immediately after
contact. Flush eyes with water.
- Do not apply directly to water or wetlands. Do not contaminate water
by cleaning of equipment or disposal of wastes. Cover or incorporate
- Data gaps exist (see below), but the Agency will not cancel or
withhold registration solely because of data gaps. The available
toxicity and environmental fate data indicate that butylate use is
unlikely to cause severe hazards to humans or wildlife; and although
this analysis of hazard cannot be considered complete until the data
gaps are filled, there is sufficient justification for continuing the
registration of butylate products.
5. SUMMARY OF MAJOR DATA GAPS
An inhalation LC50 for rats is needed, and has been required. Other
data gaps exist, but none is considered major, or as important as the
lack of an inhalation LC50. The inhalation LC50 is to be supplied by
April, 1985. The mutagenicity data and other data are to be supplied by
6. CONTACT PERSON AT EPA
401 M Street SW
Washington, DC 20460
DISCLAIMER: THE INFORMATION PRESENTED IN THIS CHEMICAL INFORMATION FACT
SHEET IS FOR INFORMATIONAL PURPOSES ONLY AND NOT TO BE USED TO FULFILL
DATA REQUIREMENTS FOR PESTICIDE REGISTRATION AND REREGISTRATION.