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cyanazine (Bladex) Herbicide Profile 12/84

                         CHEMICAL FACT SHEET FOR:
                                 CYANAZINE
FACT SHEET NUMBER: 41
DATE ISSUED: DECEMBER 31, 1984
                        1.  DESCRIPTION OF CHEMICAL
- Generic Name:  cyanazine
- Common Name:  cyanazine (WSSA, BSI, ISO); SD 15418 and WL 19805
  (code numbers)
- Trade Names:  BLADEX 80 WP or 80W, BLADEX 4-WDS or 4L, BLADEX 15G
- EPA Shaughnessy Code:  100101
- Chemical Abstracts Service (CAS) Number:  21725-46-2
- Year of Initial Registration:  1971
- Pesticide Type:  Herbicide
- Chemical Family:  Triazine
- U.S. and Foreign Producers:  Shell Chemicals (U.S.A.)
                    2.  USE PATTERNS AND FORMULATIONS
- Application sites:  To control annual grasses and broadleaf weeds in
  corn, grain sorghum, cotton, and wheat fallow.  Application for
  soybean use is pending.
- Types of formulations:  Wettable powder, flowable suspension, granular
  form
- Types and methods of application:  Aerial and ground sprays,
  application through irrigation systems.
- Application rates:
  - 1.25-4.75 lbs. a.i./A for corn, preemergence
  - 1.2-2.0 lbs. a.i./A for corn, postemergence
  - 0.5-1.3 lbs. a.i./A for cotton, preemergence
  - 0.6-1.0 lbs. a.i./A for cotton, early postemergence directed
  - 0.8-1.6 lbs. a.i./A for cotton, postemergence layby
  - 1.0-1.6 lbs. a.i./A for grain sorghum, tank mixed with propachlor
  - 0.8-1.2 lbs. a.i./A for grain sorghum, tank mixed with propazine
- Usual carriers:  Water or liquid fertilizers for preemergent use on
  corn.  Water only on postemergence treatments, grain sorghum, and
  cotton.
                         3.  SCIENCE FINDINGS
Chemical characteristics
- Physical state:  crystalline
- Color:  white
- Odor:  none
- Vapor pressure:  1.6 x 10(-9) mm Hg at 20 degrees C
- Melting point:  166.5 - 167 degrees C
- Flammability:  non-flammable
- Octanol/water partition coefficient:  not available
- Stability:  Stable at pH values of 5, 7, and 9 for >30 days.  Stable
  in sunlight, and at 75  for 100 hours.
- Solubility:  Water (23 degrees C) - 160 ppm, benzene (20 degrees C) -
  1.5%, xylene - <10%, ethanol (20 degrees C) - 4.5%, chlorobenzene -
  <10%, chloroform - 21.0%, methylcyclohexanone - 21.0%
- Unusual handling characteristics:  none reported
Toxicological Characteristics
- Acute effects
  - Acute oral LD50 - 334 mg/kg (male rats), 156 mg/kg (female rats)
    (Category II)
  - Acute dermal LD50 - >2,000 mg/kg (rabbits) (Category III)
  - Acute inhalation toxicity - LC50 >2.28 mg/kg (Category III)
  - Primary eye irritation - mild eye irritation (Category II)
- Major routes of exposure:  dermal, inhalation
- Chronic effects
  - Oncogenicity:  results inconclusive
  - Teratology:  F-344 rats - increased incidence of anophthalmia and
    microphthalmia at 25 mg/kg/day, NOEL = 10 mg/kg/day.  Increased
    incidence of diaphragmatic hernia in all treated groups.  More
    data are required to ascertain the nature of this effect.
    Sprague-Dawley rats - slight decrease in maternal body weight at
    30 mg/kg/day.  NOEL = 3 mg/kg/day.  Rabbits - maternal toxicity
    and fetotoxicity at 2 mg/kg/day.  NOEL = 1 mg/kg/day.
  - Mutagenicity:  data gap
  - Immunotoxicity:  data gap
Physiological and Biochemical Behavioral Characteristics
- Translocation:  When applied to soil, cyanazine is absorbed by the
  roots and translocated to the leaves.
Environmental Characteristics
- Absorption and leaching characteristics:  Cyanazine is reversibly
  adsorbed to soil particles.  The degree of adsorption varies with
  soil texture, water content, and organic matter content.  Leaching
  rate into the soil was measured on a sandy loam soil and found to
  be comparable to that of atrazine.
- Microbial breakdown:  Cyanazine is degraded in the soil primarily
  by microbes.
- Loss from photodegradation and/or volatilization:  Under field
  conditions there is only a minimal loss of cyanazine by either
  photodecomposition or volatilization.
- Resultant average persistence:  Half-life about 2 weeks under
  conditions favorable for plant growth.
- Half-life in water:  unknown.
Ecological Characteristics
- Hazards to birds:  Data are incomplete.  Preliminary data show low
  toxicity, suggesting minimal hazards.
- Hazards to fish and aquatic invertebrates:  Data are incomplete.
  Preliminary data show low toxicity, suggesting minimal hazards.
- Potential problems with endangered species:  No hazards indicated.
Tolerance Assessment
- List of crops and tolerances (CFR 180.307):  corn, fodder - 0.2 ppm;
  corn, forage - 0.2 ppm; corn, fresh (Inc. sweet)(K+CWHR) - 0.05 ppm;
  corn, grain - 0.05 ppm; cotton, seed - 0.05 ppm; sorghum, forage -
  0.05 ppm; sorghum, fodder - 0.05 ppm; sorghum, grain - 0.05 ppm;
  wheat, forage, green - 0.1 ppm; wheat, grain - 0.1 ppm; wheat,
  straw - 0.1 ppm.
- List of food contact uses:  corn, cotton (oil), sorghum, wheat.
- Results of tolerance assessment:  No ADI can be set at this time.
            4.  SUMMARY OF REGULATORY POSITION AND RATIONALE
- Use classification:  Reclassified (by the Registration Standard) as a
  Restricted Use chemical because of teratogenic effects, and because
  it is found in groundwater.
- Use, formulation, or geographic restrictions:  Manufacturing-use
  products may only be formulated into end-use products intended for
  use as a herbicide on corn, cotton, sorghum, or fallow land, or
  winter wheat.
- Unique label warning statements:
  - Use classification statements:  Labels of all formulated products
    must bear the following statements:
    - RESTRICTED USE PESTICIDE:  Because cyanazine can leach into
      groundwater, and has produced birth defects in laboratory animals,
      this product may be applied only by certified applicators or
      persons under their direct supervision.; and
    - Cyanazine is a pesticide which can travel (seep or leach) through
      soil and can contaminate groundwater which may be used as drinking
      water.  Cyanazine has been found in groundwater as a result of
      agricultural use.  Users are advised not to apply cyanazine where
      the water table (groundwater) is close to the surface and where
      the soils are very permeable, i.e. well-drained soils such as
      loamy sands.  Your local agricultural agencies can provide further
      information on the type of soil in your area and the location of
      groundwater.
- Precautionary statements:  Labels of manufacturing-use products and
  end-use products (EUPs) must bear the statements:  (Hazards to
  Humans Statements)
  - WARNING:  May be fatal if swallowed.  Harmful if inhaled or
    absorbed through the skin.  Causes substantial but temporary eye
    injury.  Avoid breathing dust (vapor or spray mist).  Avoid
    contact with skin, eyes, or clothing.  Do not get in eyes or on
    clothing.  Wear a face shield.  Wash thoroughly with soap and
    water after handling and before eating or smoking.  Remove contam-
    inated clothing and wash before reuse.; and
  - Use of this product may be hazardous to your family's health.
    This product has been determined to cause birth defects in
    laboratory animals.  Exposure of women of child-bearing age to
    cyanazine should be avoided.
- Statements of practical treatment:
  - If on skin:  Wash with plenty of soap and water.  Get medical
    attention.
  - If in eyes:  Flush with plenty of water.  Call a physician.
  - If swallowed:  Call a physician or Poison Control Center.  Drink
    1 or 2 glasses of water and induce vomiting by touching back of
    throat with finger.  Do not induce vomiting or give anything by
    mouth to an unconscious person.
- Environmental hazard statement:  The following specific statements
  must appear on the labels of all manufacturing use products:
  - Do not discharge effluent containing this product into lakes,
    streams, ponds, estuaries, oceans, or public waters unless this
    product is specifically identified and addressed in an NPDES
    permit.  Do not discharge effluent containing this product to
    sewer systems without previously notifying the sewage treatment
    plant authority.  For guidance, contact your State Water Board or
    Regional Office of the EPA.
  - The labels of EUPs intended for outdoor use must bear one of the
    following statements, depending on the formulation of the product:
    - Granular products must bear the statement:  Do not apply
      directly to water or wetlands.  In case of spills, collect for
      user or properly dispose of the granules.  Do not contaminate
      water by cleaning of equipment or disposal of wastes.
    - Non-granular products must bear the statement:  Do not apply
      directly to water or wetlands.  Do not contaminate water by
      cleaning of equipment or disposal of wastes.
  - The label of all products (except those, if any, intended solely
    for household use) must bear the appropriate container disposal
    statement, as will be given in Appendix IV-5 of the guidance
    package.
  - The required statements listed in this standard must appear on the
    labels of all MUPs and EUPs released for shipment after June 30,
    1985.  After review of data to be submitted under this standard,
    the Agency may impose additional label requirements.
- Summary of risk/benefit analysis:  Cyanazine produces teratogenic
  effects in laboratory animals.  Exposure to the public through the
  dietary route is not sufficiently large to exceed the risk criterion
  in 40 CFR 162.11.  Margins of safety are adequate for that route.
  However, the dermal exposure rates of mixer/loaders and applicators
  are comparable to levels at which effects occur in experimental
  animals.  This triggers the risk Criterion in 40 CFR 162.11, sending
  cyanazine into the Special Review Process.  The benefits of cyanazine
  are primarily from its effectiveness as a herbicide to corn, which
  accounts for 96% of total use.  Available alternatives to cyanazine
  do not have as broad a spectrum of weed control.  The most widely
  used alternative is atrazine, which may have more persistent residues
  and leaches through the ground at the same rate as cyanazine.  On
  cotton (3% total use) the alternatives again do not provide as broad
  a spectrum of weed control.
                  5.  SUMMARY OF MAJOR DATA GAPS
Dates when major data gaps are due to be filled:
- Statement of composition (1), Discussion of formation of unintentional
  ingredients (1), Preliminary analysis of samples (1), Certification
  of limits (1,2), Analytical methods and data for enforcement of
  limits (1,2), Density, Bulk Density, or Specific Gravity (1),
  Dissociation Constant (1), Octanol/water partition coefficient (1),
  pH (1,2), Oxidizing/Reducing Action (1,2), Flammability (1,2),
  Explodability (1,2), Storage Stability (1,2), Livestock residues,
  Plant residues, Animal residues, Storage stability data, Magnitude of
  the residue for each food use, Hydrolysis, Photodegradation (water,
  soil), Metabolism studies in lab, Mobility studies - leaching and
  absorption/desorption, Dissipation studies in field, Primary eye
  irritation (2,3,4), Primary dermal sensitization (4), Avian dietary
  toxicity, and Acute toxicity to freshwater invertebrates - all due six
  months after publication of the Standard.
- Monitoring of surface and groundwater - due 18 months after publica-
  tion of the Standard.
- Reproduction (2-generation), Chromosomal aberration, and Other
  genotoxic effects - due 20 months after publication of the Standard.
- Teratogenicity - due one year after publication of the Standard.
- 90-day feeding (rodent, non-rodent), and Oncogenicity - due four
  years after publication of the Standard.
NOTES:
(1) - Data are required on the technical material.
(2) - Data are required on the 94% technical, which is used as a
      manufacturing use product, and the 28.2% flowable intermediate.
(3) - Data are required on all wettable powder formulations.
(4) - Data are required on all liquid formulations.
                  6.  CONTACT PERSON AT EPA
Robert Taylor
U.S. Environmental Protection Agency
TS-767-C
401 M Street S.W.
Washington, DC  20460
(703)557-1650
DISCLAIMER:
THE INFORMATION PRESENTED IN THIS CHEMICAL INFORMATION FACT SHEET
IS FOR INFORMATIONAL PURPOSES ONLY AND NOT TO BE USED TO FULFILL
DATA REQUIREMENTS FOR PESTICIDE REGISTRATION AND REREGISTRATION.