cycloate (Ro-Neet) Herbicide Profile 3/85
CHEMICAL NAME: S-ethyl N-ethylthiocyclohexanecarbamate (58)
TRADE NAME(S): Ro-Neet (58)
FORMULATION(S): Emulsifiable concentrate (6 lb/gal), granule (10%)
TYPE: (Mono)thiocarbamate herbicide
BASIC PRODUCER(S): Stauffer Chemical Co.
Agricultural Chemical Div.
Westport, CT 06881
STATUS: General use
PRINCIPAL USES: For use on sugar beets, spinach, and table beets to
control annual grasses, nutgrass, certain perennial
grasses, and many broadleaf weeds (56).
APPLICATION METHOD(S): For optimum weed control under normal soil and
climate conditions, cycloate must either be mechanically incorporated
into the soil to a depth of 5 to 7.6 cm (2 to 3 inches) immediately
after application or applied subsurface with suitable injection
Cycloate is a selective herbicide which will provide effective
preemergence control of nutsedge (Cyperus spp.) and annual grasses.
Broadleaf weeds such as black nightshade (Solanum nigrum), hairy
nightshade (Solanum villosum), henbit (Lamium spp.), lambsquarters
(Chenopodium album), purslane (Portulaca oleracea), redroot pigweed
(Amaranthus retroflexus), shepherdspurse (Capsella bursapastoris), and
small stinging nettle (burning nettle) (Urtica urens) will be
controlled if application is made when conditions are favorable for
An analog of EPTC. Six to twelve weeks' control may be expected
II. PHYSICAL PROPERTIES
MOLECULAR FORMULA: C11 H21 NOS (58)
MOLECULAR WEIGHT: 215.4 (58)
PHYSICAL STATE: Colorless liquid (pure compound) (58); clear liquid
(99% pure) (62).
ODOR: Aromatic odor (99% pure compound) (62)
MELTING POINT: 11.5 C (supercools readily) (99% pure compound)
BOILING POINT: 145 C/10 mmHg (99% pure compound) (62)
VAPOR PRESSURE: 830 mPa at 25 C (99% pure compound) (62)
SOLUBILITY: 75 mg/l water at 20 C (99% pure compound) (62)
III. HEALTH HAZARD INFORMATION
OSHA STANDARD: None established
NIOSH RECOMMENDED LIMIT: None established
ACGIH RECOMMENDED LIMIT: None established
A. ACUTE TOXICITY
DERMAL: LD50 = >4640 mg/kg; no signs of toxicity were
observed at 4640 mg/kg; non-irritating to the
rabbit skin (rabbit; technical product, Ro-Neet
ORAL: LD50 = 2000-3190 mg/kg (male rat, technical
product); 3160-4100 mg/kg (female rat, technical
product); 3160 mg/kg (male rat, Ro-Neet 6E); 3690
mg/kg (female rat, Ro-Neet 6E) (58).
LD50 = >4640 mg/kg; a single oral dose of 4640
mg/kg produced a mild decrease in physical activity
with no mortailty (rat, Ro-Neet 10-G) (29w).
LD50 = 2710 mg/kg (male and female rat) (62).
EYES: Non-irritating to the rabbit eye (Ro-Neet technical)
B. SUBACUTE AND CHRONIC TOXICITY:
Daily ingestion of 60, 120, 240, 480 mg/kg/day by mice for six
weeks and 30 mg/kg/day followed by 960 mg/kg/day for 3 weeks resulted
in loss of body weight and decreased food consumption at 960 mg/kg
only. Other parameters were not examined.
Daily ingestion of 60, 120 and 240 mg/kg/day by dogs for thirteen
weeks resulted in no adverse effects.
Daily ingestion of 8, 24 and 72 mg/kg/day by rats for 26 weeks
resulted in no treatment related clinical signs, reduced body weight
gain at 24 and 72 mg/kg/day, lowered hemoglobin and decreased
erythrocyte cholinesterase at 8, 24 and 72 mg/kg/day (29v).
A 90-day dietary feed study was conducted in rats. A no-effect
level was established at 55 mg/kg/day.
A 90-day dietary feed study was conducted in dogs. A no-effect
level was established at 240 mg/kg/day (58).
Negative in the Ames Test (mutagenicity) (Ro-Neet technical)
IV. ENVIRONMENTAL CONSIDERATIONS
Behavior In Or On Soils
1. Adsorption and leaching characteristics in basic soil types:
Cycloate is quite resistant to leaching in heavy clay soils
and high organic soils. In loamy sand it leached downward
7.6 to 15.2 cm (3 to 6 inches) with 20 cm (8 inches) of
water. Cycloate leached less than EPTC and pebulate.
2. Microbial breakdown: Microbial breakdown is responsible for a
large part of the disappearance of cycloate from soils when
incorporated in the soil to a depth of 5 to 7.6 cm (2 to 3
3. Loss from photodecomposition and/or volatilization: Cycloate is
lost from moist soils by vaporization when applied to the
soil surface without incorporation. Very little loss occurs
after application to dry soil surfaces.
4. Resultant average persistence at recommended rates: Under crop
growing conditions, cycloate had a half life of 4 to 8 weeks
in several soils. In a loam soil at 21 to 27 C (70 to 80F) the
half life was 3.5 weeks (58).
General toxicity to wildlife and fish:
a. The LC50 of RO-NEET 6E in rainbow trout is 5.6 ppm for a
b. The LC50 of technical cycloate in rainbow trout is 4.5 ppm
for a 96-hr exposure.
c. The LC50 of RO-NEET 6E in mosquito fish (G. afinis) is 10 ppm
for a 96-hr. exposure.
d. The LC50 of RO-NEET 6E in bobwhite quail is in excess of
56,000 ppm for a 7-day feed treatment (58).
V. EMERGENCY AND FIRST AID PROCEDURES
The chemical information provided below has been condensed from
original source documents, primarily from "Recognition and Management
of Pesticide Poisonings", 3rd ed. by Donald P. Morgan, which have been
footnoted. This information has been provided in this form for your
convenience and general guidance only. In specific cases, further
consultation and reference may be required and is recommended. This
information is not intended as a substitute for a more exhaustive
review of the literature nor for the judgement of a physician or other
If poisoning is suspected, do not wait for symptoms to develop.
Contact a physician, the nearest hospital, or the nearest Poison
SYMPTOMS AND SIGNS OF POISONING: Some of these agents
(mono)thiocarbamates) are irritating to skin and respiratory mucous
membranes, causing ITCHING, SCRATCHY THROAT, SNEEZING, and COUGH, if
excessive amounts of spray or dust are inhaled. Apart from this
effect, toxic potential is low. Neurotoxic and post-ethanol "Antabuse"
reactions are not known to occur as a result of contact with these
particular compounds (25).
SKIN CONTACT: WASH contaminating chemical from SKIN and HAIR with
soap and water. Persons sensitive to thiram (rubber-sensitive) should
be permanently REMOVED FROM CONTACT with compounds of this nature (25).
A. Give SYRUP OF IPECAC, followed by 1-2 glasses of water, to induce
vomiting (adults: 30 ml; children under 12 years: 15 ml).
Follwing emesis, administer 30-50 gm ACTIVATED CHARCOAL to bind
toxicant remaining in the gut.
B. Follow charcoal with SODIUM or MAGNESIUM SULFATE, 0.25 gm/kg, to
remove toxicant from the gut by catharsis (25).
INHALATION: Remove from contaminated atmosphere. If breathing
has ceased, clear the victim's airway and start mouth-to-mouth
artificial respiration, which may be supplemented by the use of a
bag-mask respirator, or a manually triggered oxygen supply capable of
delivering 1 liter/second or more. If the victim is breathing, oxygen
may be administered from a demand-type or continuous flow inhalator,
and preferably with a physician's advice. Contact a physician
immediately (Ro-Neet technical) (29v).
EYE CONTACT: FLUSH contaminate from EYES with fresh water for
10-15 minutes (25).
VI. FIRE AND EXPLOSION INFORMATION
A closed cup flash point of 282 F (Ro-Neet technical) (29v).
Flash point (TOC) - 139 C; fire point - 149 C (58).
Firefighting Technique: Wear full face self-contained breathing
apparatus and impervious clothing (gloves, hats, safety goggles, suits
and boots) of rubber. Personnel exposure must be prevented and
nonessential personnel evacuated from the immediate area. Ro-Neet may
decompose under fire conditions to give off toxic irritants. If
containers are not leaking, keep cooled with a water spray (29v).
No incompatibilities known or expected. Noncorrosive (58).
VIII. PROTECTIVE MEASURES
STORAGE AND HANDLING: Apparently indefinite storage life under normal
ambient conditions (58). Containers should be stored in a cool, dry,
well-ventilated area. Store away from flammable materials and sources
of heat and flame. Do not store near seeds, fertilizers or foodstuffs.
Exercise due caution to prevent damage to or leakage from the container
(29w). All food must be kept in a separate area away from the working
location. Eating, drinking, smoking and carrying of tobacco-products
should be prohibited in areas where there is a potential for exposure.
Before eating or consuming beverages, face and hands sould be
thoroughly washed (Ro-Neet technical) (29v).
PROTECTIVE CLOTHING: Dermal contact and exposure must be prevented
through the use of protective clothing, gloves and footwear. Showers
shold be taken at the end of the work day and clean clothing should be
provided at the start of each day. Soiled work clothes should not be
taken home (Ro-Neet technical) (29v).
PROTECTIVE EQUIPMENT: This material should only be handled in
well-ventilated areas. Where adequate ventilation is not available and
there is a possibility of exposure to vapor, aerosol or mist,
inhalation exposure can be controlled through the use of a NIOSH-MESA
approved pesticide respirator with an organic vapor filter in
combination with a particulate pre-filter (Ro-Neet technical) (29v).
IX. PROCEDURES FOR SPILLS AND LEAKS
IN CASE OF EMERGENCY, CALL, DAY OR NIGHT
PESTICIDE TEAM SAFETY NETWORK/CHEMTREC
Make sure all personnel involved in spill are aware of the hazards
associated with this material.
A small spill can be handled routinely considering the physical and
hazardous properties of the product as well as the location of the
spill. Use adequate ventilation and wear an air supplied respirator to
prevent inhalation contact. Wear protective clothing to prevent skin
and eye contact. Soak up pooled liquid as follows:
1. Spread a suitable absorbent such as clay on the liquid.
2. Place sweepings in an open drum.
3. Generously cover the contaminated area with a common household
detergent (e.g. Tide). Using a stiff brush, work the detergent
into the spill material, forming a slurry. Brush the slurry into
cracks and crevices; and allow to stand for 2 to 3 minutes. Be
careful to completely avoid skin or eye contact; do not splatter
on ones self or bystanders.
4. Spread absorbents on the slurried liquid, and shovel the absorbed
material into an open drum.
5. Repeat if necessary.
6. Flush the area with water, while observing proper environmental
7. Seal drum and dispose of contaminated material in an approved
Larger spills must be handled according to a predetermined plan. For
assistance in developing a plan, contact Stauffer's Agricultural
Chemical Division, Westport, CT 06880 (29v).
X. LITERATURE CITED
8b. Thomson, W.T. 1981. Agricultural chemicals - book 2:
herbicides. Revised ed. Thomson Publications, Fresno, CA.
25. Morgan, D.P. 1982. Recognition and management of pesticide
poisonings, 3rd ed. U.S. Environmental Protection Agency,
Washington, DC. 120 pp.
29v. Stauffer Chemical Company, Agricultural Chemical Division. 1978.
Product safety information: Ro-Neet technical. Westport, CT.
29w. Stauffer Chemical Company, Agricultural Chemical Division. 1980.
Product safety information: Ro-Neet 10-G. Westport, CT.
56. Farm Chemicals Handbook, 70th ed. 1984. R. T. Meister, G. L.
Berg, C. Sine, S. Meister, and J. Poplyk, eds. Meister
Publishing Co., Willoughby, OH.
58. Weed Science Society of America, Herbicide Handbook Committee.
1983. Herbicide handbook of the weed science society of
America, 5th ed. Weed Science Society of America, Champaign,
IL. 515 pp.
62. The Pesticide Manual: A World Compendium, 7th ed. 1983. C.R.
Worthing, ed. The British Crop Protection Council, Croydon,
England. 695 pp.