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cycloate (Ro-Neet) Herbicide Profile 3/85

                                      cycloate
      CHEMICAL NAME:      S-ethyl N-ethylthiocyclohexanecarbamate (58)
      TRADE NAME(S):      Ro-Neet (58)
      FORMULATION(S):     Emulsifiable concentrate (6 lb/gal), granule (10%)
                          (56).
      TYPE:               (Mono)thiocarbamate herbicide
      BASIC PRODUCER(S):  Stauffer Chemical Co.
                          Agricultural Chemical Div.
                          Westport, CT 06881
      STATUS:             General use
      PRINCIPAL USES:     For use on sugar beets, spinach, and table beets to
                          control annual grasses, nutgrass, certain perennial
                          grasses, and many broadleaf weeds (56).
      APPLICATION METHOD(S):  For optimum weed control under normal soil and
      climate conditions, cycloate must either be mechanically incorporated
      into the soil to a depth of 5 to 7.6 cm (2 to 3 inches) immediately
      after application or applied subsurface with suitable injection
      equipment (58).
                                    I.  EFFICACY
           Cycloate is a selective herbicide which will provide effective
      preemergence control of nutsedge (Cyperus spp.) and annual grasses.
      Broadleaf weeds such as black nightshade (Solanum nigrum), hairy
      nightshade (Solanum villosum), henbit (Lamium spp.), lambsquarters
      (Chenopodium album), purslane (Portulaca oleracea), redroot pigweed
      (Amaranthus retroflexus), shepherdspurse (Capsella bursapastoris), and
      small stinging nettle (burning nettle) (Urtica urens) will be
      controlled if application is made when conditions are favorable for
      germination (58).
           An analog of EPTC.  Six to twelve weeks' control may be expected
      (8b).
                              II.  PHYSICAL PROPERTIES
      MOLECULAR FORMULA:  C11 H21 NOS (58)
      MOLECULAR WEIGHT:   215.4 (58)
      PHYSICAL STATE:     Colorless liquid (pure compound) (58); clear liquid
                          (99% pure) (62).
      ODOR:               Aromatic odor (99% pure compound) (62)
      MELTING POINT:      11.5 C (supercools readily) (99% pure compound)
                          (62).
      BOILING POINT:      145 C/10 mmHg (99% pure compound) (62)
      VAPOR PRESSURE:     830 mPa at 25 C (99% pure compound) (62)
      SOLUBILITY:         75 mg/l water at 20 C (99% pure compound) (62)
                          III.  HEALTH HAZARD INFORMATION
      OSHA STANDARD:  None established
      NIOSH RECOMMENDED LIMIT:   None established
      ACGIH RECOMMENDED LIMIT:   None established
      TOXICOLOGY
           A.  ACUTE TOXICITY
               DERMAL:  LD50 = >4640 mg/kg; no signs of toxicity were
                        observed at 4640 mg/kg; non-irritating to the
                        rabbit skin (rabbit; technical product, Ro-Neet
                        10-G) (29v,w).
               ORAL:    LD50 = 2000-3190 mg/kg (male rat, technical
                          product); 3160-4100 mg/kg (female rat, technical
                          product); 3160 mg/kg (male rat, Ro-Neet 6E); 3690
                          mg/kg (female rat, Ro-Neet 6E) (58).
                        LD50 = >4640 mg/kg; a single oral dose of 4640
                          mg/kg produced a mild decrease in physical activity
                          with no mortailty (rat, Ro-Neet 10-G) (29w).
                        LD50 = 2710 mg/kg (male and female rat) (62).
               EYES:    Non-irritating to the rabbit eye (Ro-Neet technical)
                        (29v).
           B.  SUBACUTE AND CHRONIC TOXICITY:
           Daily ingestion of 60, 120, 240, 480 mg/kg/day by mice for six
      weeks and 30 mg/kg/day followed by 960 mg/kg/day for 3 weeks resulted
      in loss of body weight and decreased food consumption at 960 mg/kg
      only.  Other parameters were not examined.
           Daily ingestion of 60, 120 and 240 mg/kg/day by dogs for thirteen
      weeks resulted in no adverse effects.
           Daily ingestion of 8, 24 and 72 mg/kg/day by rats for 26 weeks
      resulted in no treatment related clinical signs, reduced body weight
      gain at 24 and 72 mg/kg/day, lowered hemoglobin and decreased
      erythrocyte cholinesterase at 8, 24 and 72 mg/kg/day (29v).
           A 90-day dietary feed study was conducted in rats.  A no-effect
      level was established at 55 mg/kg/day.
           A 90-day dietary feed study was conducted in dogs.  A no-effect
      level was established at 240 mg/kg/day (58).
           Negative in the Ames Test (mutagenicity) (Ro-Neet technical)
      (29v).
                         IV.  ENVIRONMENTAL CONSIDERATIONS
      Behavior In Or On Soils
      1.   Adsorption and leaching characteristics in basic soil types:
             Cycloate is quite resistant to leaching in heavy clay soils
             and high organic soils.  In loamy sand it leached downward
             7.6 to 15.2 cm (3 to 6 inches) with 20 cm (8 inches) of
             water.  Cycloate leached less than EPTC and pebulate.
      2.   Microbial breakdown:  Microbial breakdown is responsible for a
             large part of the disappearance of cycloate from soils when
             incorporated in the soil to a depth of 5 to 7.6 cm (2 to 3
             inches).
      3.   Loss from photodecomposition and/or volatilization:  Cycloate is
             lost from moist soils by vaporization when applied to the
             soil surface without incorporation.  Very little loss occurs
             after application to dry soil surfaces.
      4.   Resultant average persistence at recommended rates:  Under crop
             growing conditions, cycloate had a half life of 4 to 8 weeks
             in several soils.  In a loam soil at 21 to 27 C (70 to 80F) the
             half life was 3.5 weeks (58).
      General toxicity to wildlife and fish:
           a.   The LC50 of RO-NEET 6E in rainbow trout is 5.6 ppm for a
                96-hr exposure.
           b.   The LC50 of technical cycloate in rainbow trout is 4.5 ppm
                for a 96-hr exposure.
           c.   The LC50 of RO-NEET 6E in mosquito fish (G. afinis) is 10 ppm
                for a 96-hr. exposure.
           d.   The LC50 of RO-NEET 6E in bobwhite quail is in excess of
                56,000 ppm for a 7-day feed treatment (58).
                       V.  EMERGENCY AND FIRST AID PROCEDURES
           The chemical information provided below has been condensed from
      original source documents, primarily from "Recognition and Management
      of Pesticide Poisonings", 3rd ed. by Donald P.  Morgan, which have been
      footnoted.  This information has been provided in this form for your
      convenience and general guidance only.  In specific cases, further
      consultation and reference may be required and is recommended.  This
      information is not intended as a substitute for a more exhaustive
      review of the literature nor for the judgement of a physician or other
      trained professional.
           If poisoning is suspected, do not wait for symptoms to develop.
      Contact a physician, the nearest hospital, or the nearest Poison
      Control Center.
      SYMPTOMS AND SIGNS OF POISONING:  Some of these agents
      (mono)thiocarbamates) are irritating to skin and respiratory mucous
      membranes, causing ITCHING, SCRATCHY THROAT, SNEEZING, and COUGH, if
      excessive amounts of spray or dust are inhaled.  Apart from this
      effect, toxic potential is low.  Neurotoxic and post-ethanol "Antabuse"
      reactions are not known to occur as a result of contact with these
      particular compounds (25).
           SKIN CONTACT:  WASH contaminating chemical from SKIN and HAIR with
      soap and water.  Persons sensitive to thiram (rubber-sensitive) should
      be permanently REMOVED FROM CONTACT with compounds of this nature (25).
           INGESTION:
      A.   Give SYRUP OF IPECAC, followed by 1-2 glasses of water, to induce
           vomiting (adults:  30 ml; children under 12 years:  15 ml).
           Follwing emesis, administer 30-50 gm ACTIVATED CHARCOAL to bind
           toxicant remaining in the gut.
      B.   Follow charcoal with SODIUM or MAGNESIUM SULFATE, 0.25 gm/kg, to
           remove toxicant from the gut by catharsis (25).
           INHALATION:  Remove from contaminated atmosphere.  If breathing
      has ceased, clear the victim's airway and start mouth-to-mouth
      artificial respiration, which may be supplemented by the use of a
      bag-mask respirator, or a manually triggered oxygen supply capable of
      delivering 1 liter/second or more.  If the victim is breathing, oxygen
      may be administered from a demand-type or continuous flow inhalator,
      and preferably with a physician's advice.  Contact a physician
      immediately (Ro-Neet technical) (29v).
           EYE CONTACT:  FLUSH contaminate from EYES with fresh water for
      10-15 minutes (25).
                        VI.  FIRE AND EXPLOSION INFORMATION
           A closed cup flash point of 282 F (Ro-Neet technical) (29v).
      Flash point (TOC) - 139 C; fire point - 149 C (58).
      Firefighting Technique:  Wear full face self-contained breathing
      apparatus and impervious clothing (gloves, hats, safety goggles, suits
      and boots) of rubber.  Personnel exposure must be prevented and
      nonessential personnel evacuated from the immediate area.  Ro-Neet may
      decompose under fire conditions to give off toxic irritants.  If
      containers are not leaking, keep cooled with a water spray (29v).
                                VII.  COMPATIBILITY
           No incompatibilities known or expected.  Noncorrosive (58).
                             VIII.  PROTECTIVE MEASURES
      STORAGE AND HANDLING:  Apparently indefinite storage life under normal
      ambient conditions (58).  Containers should be stored in a cool, dry,
      well-ventilated area.  Store away from flammable materials and sources
      of heat and flame.  Do not store near seeds, fertilizers or foodstuffs.
      Exercise due caution to prevent damage to or leakage from the container
      (29w).  All food must be kept in a separate area away from the working
      location.  Eating, drinking, smoking and carrying of tobacco-products
      should be prohibited in areas where there is a potential for exposure.
      Before eating or consuming beverages, face and hands sould be
      thoroughly washed (Ro-Neet technical) (29v).
      PROTECTIVE CLOTHING:  Dermal contact and exposure must be prevented
      through the use of protective clothing, gloves and footwear.  Showers
      shold be taken at the end of the work day and clean clothing should be
      provided at the start of each day.  Soiled work clothes should not be
      taken home (Ro-Neet technical) (29v).
      PROTECTIVE EQUIPMENT:  This material should only be handled in
      well-ventilated areas.  Where adequate ventilation is not available and
      there is a possibility of exposure to vapor, aerosol or mist,
      inhalation exposure can be controlled through the use of a NIOSH-MESA
      approved pesticide respirator with an organic vapor filter in
      combination with a particulate pre-filter (Ro-Neet technical) (29v).
                        IX.  PROCEDURES FOR SPILLS AND LEAKS
                      IN CASE OF EMERGENCY, CALL, DAY OR NIGHT
                                   (800) 424-9300
                       PESTICIDE TEAM SAFETY NETWORK/CHEMTREC
           Make sure all personnel involved in spill are aware of the hazards
      associated with this material.
      A small spill can be handled routinely considering the physical and
      hazardous properties of the product as well as the location of the
      spill.  Use adequate ventilation and wear an air supplied respirator to
      prevent inhalation contact.  Wear protective clothing to prevent skin
      and eye contact.  Soak up pooled liquid as follows:
      1.   Spread a suitable absorbent such as clay on the liquid.
      2.   Place sweepings in an open drum.
      3.   Generously cover the contaminated area with a common household
           detergent (e.g. Tide).  Using a stiff brush, work the detergent
           into the spill material, forming a slurry.  Brush the slurry into
           cracks and crevices; and allow to stand for 2 to 3 minutes.  Be
           careful to completely avoid skin or eye contact; do not splatter
           on ones self or bystanders.
      4.   Spread absorbents on the slurried liquid, and shovel the absorbed
           material into an open drum.
      5.   Repeat if necessary.
      6.   Flush the area with water, while observing proper environmental
           considerations.
      7.   Seal drum and dispose of contaminated material in an approved
           pesticide dump.
      Larger spills must be handled according to a predetermined plan.  For
      assistance in developing a plan, contact Stauffer's Agricultural
      Chemical Division, Westport, CT 06880 (29v).
                               X.  LITERATURE CITED
       8b. Thomson, W.T.  1981.  Agricultural chemicals - book 2:
               herbicides.  Revised ed.  Thomson Publications, Fresno, CA.
               274 pp.
      25.  Morgan, D.P.  1982.  Recognition and management of pesticide
               poisonings, 3rd ed.  U.S. Environmental Protection Agency,
               Washington, DC.  120 pp.
      29v. Stauffer Chemical Company, Agricultural Chemical Division.  1978.
               Product safety information:  Ro-Neet technical.  Westport, CT.
      29w. Stauffer Chemical Company, Agricultural Chemical Division.  1980.
               Product safety information:  Ro-Neet 10-G.  Westport, CT.
      56.  Farm Chemicals Handbook, 70th ed.  1984.  R. T. Meister, G. L.
               Berg, C. Sine, S. Meister, and J. Poplyk, eds.  Meister
               Publishing Co., Willoughby, OH.
      58.  Weed Science Society of America, Herbicide Handbook Committee.
               1983.  Herbicide handbook of the weed science society of
               America, 5th ed.  Weed Science Society of America, Champaign,
               IL.  515 pp.
      62.  The Pesticide Manual:  A World Compendium, 7th ed.  1983.  C.R.
               Worthing, ed.  The British Crop Protection Council, Croydon,
               England.  695 pp.
      3/11/85