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karbutilate (Tanzene, Tandex) Herbicide Profile 3/85

                                    karbutilate
      CHEMICAL NAME:      m-(3,3-Dimethylureido)phenyl-tert-butyl-carbamate
                          (56)
      TRADE NAME(S):      Tandex (discontinued by FMC Corp.), Tanzene (56).
                          Tandex (Ciba-Geigy) (58).
      FORMULATION(S):     Granules, 4%, 10%; wettable powder 80%.  Tanzene
                          80W is a prepackaged mixture of simazine and
                          karbutilate in a 2:1 ratio (56).
      TYPE:               Herbicide
      BASIC PRODUCER(S):  Ciba-Geigy Corp., Agricultural Div.
                          P.O. Box 18300
                          Greensboro, NC 27419
      STATUS:             General use
      PRINCIPAL USES:  Control of annual and perennial broadleaf weeds and
      grasses, brush and vines.  Useful on railroad, utility and pipeline
      rights-of-way, drainage ditch banks, industrial plant sites and noncrop
      farm areas (56).
      APPLICATION METHODS:  Preemergence or postemergence applications (58).
                                   I.  EFFICACY
           To be developed.
                             II.  PHYSICAL PROPERTIES
      MOLECULAR FORMULA:  C14 H21 N3 O3 (62)
      MOLECULAR WEIGHT:   279.3 (62)
      PHYSICAL STATE:     White crystalline solid (pure compound) (58).
      ODOR:               Nearly odorless (pure compound) (11d).
      MELTING POINT:      176-176.5 (pure compound); 160 C minimum (technical
                          product) (11d).
      VAPOR PRESSURE:     6.0 nPa at 20 C (pure compound) (62).
      SOLUBILITY:         325 mg/l water at 20 C (pure compound) (62).
                          III.  HEALTH HAZARD INFORMATION
      OSHA STANDARD:  None established
      NIOSH RECOMMENDED LIMIT:  None established
      ACGIH RECOMMENDED LIMIT:  None established
      TOXICOLOGY
           A.  ACUTE TOXICITY
               DERMAL:  The acute dermal LD50 of the herbicide to albino
                          rats is greater than 15,400 mg/kg of body weight
                          (58).
                        Nonirritant to skin of rabbits (62).
               ORAL:    The acute oral LD50 of the active ingredient to
                          albino rats is 3,000 mg/kg of body weight (58).
                        LD50 (80% wettable powder) = 28,200 mg/kg (male rat);
                          18,800 mg/kg (female rat) (11d).
               INHALATION:  LC50 = >3.7 mg/liter (rat) (11d).
               EYES:    Slight irritant to eyes (62).
           B.  SUBACUTE AND CHRONIC TOXICITY:
           In 90-day feeding trials NEL was:  for rats 1000 mg/kg diet (70
      mg/kg daily); for dogs 15 mg/kg daily (62).
                        IV.  ENVIRONMENTAL  CONSIDERATIONS
           LC50 is:  for rainbow trout >135 mg/l; for bluegill >75 mg/l (62).
           General toxicity to wildlife and fish:  nontoxic (58).
           Once karbutilate is moved into the soil by moisture, and fixed,
      lateral movement is minimal.  Lateral movement must not be confused
      with physical wash.  Most herbicides are subject to physical washing by
      excessive rainfall before they become incorporated into the soil.
           Microbial activity is a factor in the degradation of karbutilate
      in soil (11d).
           The 8-day oral results from karbutilate technical are as follows:
           Bobwhite Quail - LC50 >10,000 ppm
           Mallard Duck - LC50 >4,640 ppm (11d).
                      V.  EMERGENCY AND FIRST AID PROCEDURES
           The chemical information provided below has been condensed
      from original source documents, primarily from "Recognition and
      Management of Pesticide Poisonings", 3rd ed. by Donald P.  Morgan,
      which have been footnoted.  This information has been provided in
      this form for your convenience and general guidance only.  In
      specific cases, further consultation and reference may be required
      and is recommended.  This information is not intended as a sub-
      stitute for a more exhaustive review of the literature nor for the
      judgement of a physician or other trained professional.
           If poisoning is suspected, do not wait for symptoms to develop.
      Contact a physician, the nearest hospital, or the nearest Poison
      Control Center.
      SYMPTOMS OF POISONING:  No human intoxication known (58).
                        VI.  FIRE AND EXPLOSION INFORMATION
           Non-flammable (58).
                                VII.  COMPATIBILITY
           Generally compatible.  Noncorrosive (58).
                            VIII.  PROTECTIVE MEASURES
      STORAGE AND HANDLING:  Stable under storage.  May be harmful if
      swallowed.  Avoid breathing dust or contact with skin or eyes.  Do not
      apply, or drain or flush equipment on or near desirable trees or other
      plants, or on areas to which their roots may extend.  Do not
      contaminate domestic or irrigation waters (58).
           Tandex and Tanzene herbicides are non-volatile and once the spray
      has been deposited, no danger from vaporization exists (56).
                       IX.  PROCEDURES FOR SPILLS AND LEAKS
                     IN CASE OF EMERGENCY, CALL, DAY OR NIGHT
                                  (800) 424-9300
                      PESTICIDE TEAM SAFETY NETWORK/CHEMTREC
                               X.  LITERATURE CITED
  Product manual:  Tandex herbicide.
               Middleport, NY.
      56.  Farm Chemicals Handbook, 70th ed.  1984.  R. T. Meister, G. L.
               Berg, C. Sine, S. Meister, and J. Poplyk, eds.  Meister
               Publishing Co., Willoughby, OH.
      58.  Weed Science Society of America, Herbicide Handbook Committee.
               1983.  Herbicide handbook of the weed science society of
               America, 5th ed.  Weed Science Society of America, Champaign,
               IL.  515 pp.
      62.  The Pesticide Manual:  A World Compendium, 7th ed.  1983.  C.R.
               Worthing, ed.  The British Crop Protection Council, Croydon,
               England.  695 pp.
      3/21/85