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monocarbamide (Enquik, WilThin) Herbicide Profile 12/87

EPA Pesticide Fact Sheet
Name of Chemical:  MONOCARBAMIDE DIHYDROGEN SULFATE
Reason for Issuance:  NEW CHEMICAL REGISTRATION
Date Issued:  Dec. 30, 1987
Fact Sheet Number:  151
                    1.  DESCRIPTION OF CHEMICAL
Chemical Name: Monocarbamide dihydrogen sulfate
Other Name: Monourea sulfuric acid adduct
Trade Name: ENQUIK
OPP Internal Control Number: 078001
Year of Initial Registration: 1987
Pesticide Type: Herbicide/Desiccant
U.S. and Foreign Producers: Union Chemicals Division, Unocal Corp
                    2. USE PATTERNS AND FORMULATIONS
- Application sites: Herbicide uses include; Onions (green & dry bulb),
  leeks, shallots, spring onions, garlic, peanuts, peas, lentils,
  dry beans, garbanzos and grass seed.  Desiccant uses include; dry
  beans, peas, lentils, peppermint and potato vines.
- Types of formulations: liquid, 81.6% active ingredient
- Types and methods of.application: Applied postemergence to crops and
  weeds as a contact pesticide.  Diluted with water and applied as a
  spray for broadcast, directed or shield spray treatments, using ground
  equipment.  A wetting agent or non-ionic surfactant may be added.
- Application rates: 20 to 309 lbs. a.i./A, depending upon application
  site
- Usual carriers: water
                       3.  SCIENCE FINDINGS
Summary science statement
- Acute toxicology data indicate that the chemical.is extremely caustic
  and corrosive.  The appropriate toxicity category is I (DANGER), based
  on primary eye and skin irritation studies.  Chronic toxicology and
  environmental fate data requirements are waived.  Avian dietary
  studies indicate that the formulated product is practically nontoxic
  to mallard ducks and bobwhite quail.  Diluted monocarbamide dihydrogen
  sulfate is less hazardous to wildlife than the undiluted chemical.
  Application is restricted to use of the diluted chemical only.
  Potential hazard to fish and wildlife including endangered species is
  minimized due to label restrictions against aerial application and
  limiting use to the following states; Alabama, Georgia, Idaho,
  Michigan, Oregon and Washington.
Chemical characteristics
- Physical state:  Viscous liquid
- Color:  Colorless
- Odor:  Odorless
- Density:  13.14 pounds per gallon
- Miscibility:  Limited miscibility in polar organic solvents.
  Not miscible with hydrocarbons and lipids.
- Vapor pressure:    Negligible up to decomposition temperature of 80oC.
- Crystallization point:  2 degrees C
- pH:  1 (aqueous solution)
- Unusual handling characteristics:  Corrosive to nylon, cotton,
  leather, aluminum and copper alloy such as brass.  Corrosive to skin
  and eyes. Explosively decomposes above 160 degrees F. Do not mix with
  nitrogen fertilizers as explosive mixtures may result.
Toxicology characteristics
- Acute toxicology results:
  - Acute oral toxicity (rat): 1,200 mg/kg (male) 350 mg/kg (female)
    Toxicity Category II
  - Acute dermal toxicity (rabbit): greater than 2 g/kg.  Study as
    terminated at 48 hours because of extreme caustic action and dermal
    necrosis.  Toxicity category was not determined.
  - Primary skin irritation (rabbit): Caustic on intact and abraded skin
    at 24 hours.  Study was terminated at 24 hours after similar results
    were obtained with 1:4 v/v dilution with water.  Toxicity Category I
  - Primary eye irritation (rabbit): Severe corneal involvement, grade 4
    chemosis of conjunctivae at 24 hours.  Because of severity of
    reaction, study was terminated at 24 hours.  Toxicity category I
  - Acute inhalation toxicity (rat): greater than 10.8 mg/l Toxicity
    category III
  - Additional data not required on acute dermal and primary eye
    irritation studies, in accordance with EPA-540/9-82-025,
    October 1982, Pesticide Assessment Guidelines Subdivision
    (Section 81-2(a)(1)) and Subdivision F (Section 81-4(d)(2)),
    respectively.
  - Chronic toxicology results.  Additional toxicology studies
    (including a three-generation reproduction study) were waived in
    accordance with provisions of 40 CFR 162.45 (c).  Toxicological
    concerns over heavy metal impurities in the sulfuric acid, have been
    adequately resolved.  Recycled (spent) sulfuric acid will not
    be used to manufacture the active ingredient.
  - Major routes of exposure:  Mixers, loaders and applicators would
    be expected to receive the most exposure via skin contact and
    inhalation.
Physiological and biochemical behavioral characteristics
- Mechanism of pesticidal action: Monocarbamide dihydrogen sulfate
  is a contact herbicide and desiccant.  The chemical disrupts cell
  membrane structures in a catalytic non-acid consumptive reaction.  The
  rate of activity is dependent upon the amount of waxy cuticle present
  on the surface of treated plants.  Plants with a significant wax
  coating are less susceptible to damage than others.
Environmental characteristics
- The environmental fate of urea and sulfuric acid are well known from
  the literature.  Environmental fate data requirements are waived.
Ecological characteristics:
- Hazards to fish and wildlife:
  - Avian dietary toxicity (Mallard): greater than 5620 ppm (49% a.i.)
  - Avian dietary toxicity (Bobwhite): greater than 5620 ppm (49% a.i.)
  - Simulated avian field Study: Results indicate that eye and foot
    damage may be pronounced for birds exposed to direct applications
    of undiluted monocarbamide dihydrogen sulfate. Application of a
    diluted solution caused some but much less damage.
  - Avian re-entry field study:  Results indicate that birds that can
    escape during ground application are unlikely to be harmed if they
    enter treated fields after application.
  - pH study in ephemeral ponds and irrigation water: The study
    indicates that under most conditions the acidifying effect of ENQUIK
    will be temporary. Only shallow ponds receiving an over-spraying of
    ENQUIK would be affected by a lowering of pH.
- Potential problems related to endangered species:  Contamination of
  habitat areas is not likely to occur as a result of runoff, since the
  chemical, once it reaches the soil, is expected to be neutralized.
  Potential hazard may exist for those endangered species receiving a
  direct spraying of ENQUIK. However, geographical restrictions and a
  prohibition against aerial application should minimize any potential
  hazard to endangered species .
- Tolerance assessments: Monocarbamide dihydrogen sulfate is exempted
  from the requirement of tolerance when used as a herbicide or
  desiccant in or on all raw agricultural commodities (40 CFR 10.1084).
          4. SUMMARY OF REGULATORY POSITION AND RATIONALE:
- Use, formulation, geographical restrictions:  Pesticidal use is
  limited to the following states; Alabama, Georgia, Idaho, Michigan,
  Oregon and Washington.  Aerial application is prohibited.
Unique label warning statements
  End-Use Product:
              Physical or Chemical Hazards
     "ENQUIK is corrosive to nylon, aluminum, and any copper
      alloy such as brass.  Do not use pumps or fittings
      containing nylon, mild steel, aluminum, brass, leather,
      natural rubber or bunam.  Non-nylon plastic and 316-L
      stainless steel are recommended for application equipment.
      Diluted ENQUIK is more corrosive to steel than the
      concentrate.  Do not allow ENQUIK to be heated above
      160 degrees F as explosive decomposition may occur.  Do not weld
      equipment containing ENQUIK.
      Do not mix with nitrogen fertilizers as explosive mixtures
      may result. Do not mix with other materials without specific
      authorization as hazardous combinations may result.
      Clothing: ENQUIK can attack cotton, nylon, and leather
      clothing.  If ENQUIK contacts clothing of this type,
      flush with plenty of water to minimize damage.  Wear non-
      nylon plastic protective clothing."
                      Human Hazards
     "Corrosive.  Causes irreversible eye damage and burns to skin.
      Face shields or goggles must be worn.  Wear suitable protective
      equipment to protect skin, such as synthetic rubber or non-nylon
      plastic apron, gloves, pants and boots.  Wash after contact with
      skin. Shower at the end of the working day.  Do not wear
      contaminated clothing.  Avoid spray.  Avoid breathing spray mist."
                  Environmental Hazards
      "This product may be harmful to wildlife directly sprayed.  Keep
       out of lakes, ponds and streams.  Do not apply directly to water
       or wetlands.  Do not contaminate water by cleaning of equipment
       or disposal of wastes.  Do not apply near waters already damaged
       by acid pollution or in areas with soils of poor buffering
       capacity if important aquatic resources are adjacent."
                     5.  SUMMARY OF DATA GAPS
None
                   6.  CONTACT PERSON AT EPA:
Robert J. Taylor
Product Manager (25), (TS-767C)
Environmental Protection Agency
401 M Street, S.W.
Washington, D.C.  20460
(703) 557-1800
DISCLAIMER: The information presented in this Pesticide Fact Sheet is 
for informational purposes only and may not be used to fulfill data 
requirements for pesticide registration and reregistration.