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monuron (Monurex, Telvar) Herbicide Profile 2/85

                                     monuron
      CHEMICAL NAME:      3-(p-chlorophenyl)-1,1-dimethylurea (56)
      TRADE NAME(S):      Monurex (56)
      FORMULATION(S):     Wettable powder 80% and technical 98% (56)
      TYPE:               Substituted urea herbicide
      BASIC PRODUCER(S):  Hopkins Agricultural Chemical Co.
                          P.O. Box 7532
                          Madison, WI 53707
      STATUS:             General use
      PRINCIPAL USES:  Monuron is somewhat more soluble in water than
      diuron and has a lower coefficient of adsorption.  As a soil sterilant
      monuron is preferred on medium to heavy soils and under intermediate
      rainfall conditions.  At sterilant dosages it controls a wide range of
      annual and perennial grasses and broadleaf weeds on noncrop areas.
      General weed control in noncropland areas (56).
                                   I.  EFFICACY
           To be developed.
                             II.  PHYSICAL PROPERTIES
      MOLECULAR FORMULA:  C9 H11 Cl N2 O (62)
      MOLECULAR WEIGHT:   198.7 (62)
      PHYSICAL STATE:     Colorless crystalline solid (pure compound) (62)
      MELTING POINT:      174-175 C (pure compound) (62)
      VAPOR PRESSURE:     67 uPa at 25 C (pure compound) (62)
      SOLUBILITY:         230 mg/l water at 25 C (pure compound) (62)
                          III.  HEALTH HAZARD INFORMATION
      OSHA STANDARD:  NA
      NIOSH RECOMMENDED LIMIT:  NA
      ACGIH RECOMMENDED LIMIT:  NA
      TOXICOLOGY
           A.  ACUTE TOXICITY
               DERMAL:  Application to the intact or abraded skin of
                        guinea-pigs produced no irritation or sensitization
                        (62).
               ORAL:    LD50 = 3600 mg/kg (rat) (62)
           B.  SUBACUTE AND CHRONIC TOXICITY:
           In feeding trials NEL for rats and dogs was 250-500 mg/kg diet (62).
                        IV.  ENVIRONMENTAL  CONSIDERATIONS
           To be developed.
                      V.  EMERGENCY AND FIRST AID PROCEDURES
           The chemical information provided below has been condensed
      from original source documents, primarily from "Recognition and
      Management of Pesticide Poisonings", 3rd ed. by Donald P.  Morgan,
      which have been footnoted.  This information has been provided in
      this form for your convenience and general guidance only.  In
      specific cases, further consultation and reference may be required
      and is recommended.  This information is not intended as a sub-
      stitute for a more exhaustive review of the literature nor for the
      judgement of a physician or other trained professional.
           If poisoning is suspected, do not wait for symptoms to develop.
      Contact a physician, the nearest hospital, or the nearest Poison
      Control Center.
      KNOWN OR SUSPECTED ADVERSE EFFECTS:  Many substituted ureas are
      moderately irritating to skin, eyes, and mucous membranes (25).
           SKIN CONTACT:  Wash contaminated skin with soap and water (25).
           INGESTION:  Ingestions of small amounts (less than 10 mg/kg
      body weight) occurring less than an hour before treatment, are probably
      best treated by:  Syrup of Ipecac, followed by 1-2 glasses of water.
      Dose for adults and children over 12 years:  30 ml.  Dose for children
      under 12 years:  15 ml (25).
           EYE CONTACT:  Flush contaminated eyes with copious amounts of
      fresh water for 15 minutes (25).
      NOTES TO PHYSICIAN:
      INGESTIONS of LARGE amounts (more than 10 mg/kg) occurring less than an
      hour before treatment, should probably be treated by gastric lavage:
      A.   INTUBATE stomach and ASPIRATE contents.
      B.   LAVAGE stomach with slurry of ACTIVATED CHARCOAL IN 0.9% saline.
           Leave 30-50 gm activated charcoal in the stomach before
           withdrawing tube.
      C.   SODIUM SULFATE, 0.25 gm/kg in tap water, as a cathartic.
           CAUTION:  Hydrocarbons (kerosene, petroleum distillates) are
                     included in some formulations of these chemicals.
                     Ingestion of very LARGE AMOUNTS may cause CNS
                     depression.  In this case, IPECAC IS CONTRAINDICATED.
                     Also, gastric intubation incurs a risk of HYDROCARBON
                     PNEUMONITIS.  For this reason observe the following
                     precautions:
                     (1)  If the victim is unconscious or obtunded and
                          facilities are at hand, insert an ENDOTRACHEAL TUBE
                          (cuffed, if available) prior to gastric intubation.
                     (2)  Keep victim's HEAD BELOW LEVEL OF STOMACH during
                          intubation and lavage (Trendelenburg, or left
                          lateral decubitus, with head of table tipped
                          downward).  Keep victim's head turned to the left.
                     (3)  ASPIRATE PHARYNX as regularly as possible to remove
                          gagged or vomited stomach contents.
      INGESTIONS occurring MORE THAN an HOUR before treatment are probably
      best treated only by ACTIVATED CHARCOAL, 30-50 gm, and SODIUM or
      MAGNESIUM SULFATE, 0.25 gm/kg, as described above.
      There are no specific antidotes for these chemicals.  Because
      manifestations of toxicity do occasionally occur in peculiarly
      predisposed individuals, MAINTAIN CONTACT with victim for at least 72
      hours so that unexpected adverse effects can be treated promptly (25).
                        VI.  FIRE AND EXPLOSION INFORMATION
           To be developed.
                                VII.  COMPATIBILITY
           To be developed.
                            VIII.  PROTECTIVE MEASURES
      STORAGE AND HANDLING:  Dry formulations are stable under normal storage
      conditions.  May irritate eyes, nose, throat, and skin.  Avoid
      breathing dust or spray mist.  Avoid contact with skin, eyes, and
      clothing (56).
                       IX.  PROCEDURES FOR SPILLS AND LEAKS
                     IN CASE OF EMERGENCY, CALL, DAY OR NIGHT
                                  (800) 424-9300
                      PESTICIDE TEAM SAFETY NETWORK/CHEMTREC
                               X.  LITERATURE CITED
      25.  Morgan, D.P.  1982.  Recognition and management of pesticide
               poisonings, 3rd ed.  U.S. Environmental Protection Agency,
               Washington, DC.  120 pp.
      56.  Farm Chemicals Handbook, 70th ed.  1984.  R. T. Meister, G. L.
               Berg, C. Sine, S. Meister, and J. Poplyk, eds.  Meister
               Publishing Co., Willoughby, OH.
      62.  The Pesticide Manual:  A World Compendium, 7th ed.  1983.  C.R.
               Worthing, ed.  The British Crop Protection Council, Croydon,
               England.  695 pp.
      2/12/85