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nicosulfuron (Accent) Herbicide Profile 6/90

           MATERIAL SAFETY DATA SHEET FOR NICOSULFURON
MATERIAL IDENTIFICATION
   NUMBER:  M0000085
   NAME:    "ACCENT" HERBICIDE
 
- "ACCENT" is a registered trademark of Du Pont.
- CAS NAME:  3-Pyridimecarboxamide,2-[[(4,6-Dimethoxy-pyrimidin-2-
  yl)amino-carbonyl]aminosulfonyl]-N,N-dimethyl
- NFPA RATING:  Health: 1 Flammability: 1 Reactivity: O
- NPCA-HMIS RATING:  Health: 1 Flammability: 1 Reactivity: O
  Personal Protection rating to be supplied by user depending on use
  conditions.
- MANUFACTURER/DISTRIBUTOR:  Du Pont, 1007 Market Street, Wilmington,
  DE  19898
- PRODUCT INFORMATION PHONE:  1-(800)441-7515
- TRANSPORTATION EMERGENCY PHONE:  1-(800)424-9300
- MEDICAL EMERGENCY PHONE:  1-(800)441-3637
 
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COMPONENTS
MATERIAL                                CAS Number         %
- Nicosulfuron )                       111991-09-4        75
- Inert ingredients                                       25
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PHYSICAL DATA
- Solubility in Water:  Dispersible
- Form:  Granule
- Color:  Tan
- Bulk Density:  45 lbs/cu ft (loose)
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HAZARDOUS REACTIVITY
- Instability:  Stable at normal temperatures and storage conditions.
- Incompatibility:  None reasonably foreseeable.
- Polymerization:  Polymerization will not occur.
FIRE AND EXPLOSION DATA
- Not a fire and explosion hazard.
FIRE AND EXPLOSION HAZARDS
- None.
EXTINGUISHING MEDIA
- Water. Foam. Dry Chemical. C02.
SPECIAL FIRE FIGHTING INSTRUCTIONS
   Evacuate personnel to a safe area. Keep personnel removed & upwind of 
fire.  Wear self-contained breathing apparatus.  Runoff from fire 
control may be a pollution hazard.
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HEALTH HAZARD INFORMATION
WARNING!  Causes eye irritation.  Harmful if absorbed through the skin.
ROUTES OF EXPOSURE AND EFFECTS:
- Acute oral-(rat) LD50 greater than 5,000 mg/kg of body weight.  Very
  low toxicity by ingestion.
- Acute dermal-(rabbit)  LD50 greater than 2,000 mg/kg. Slight to
  moderately toxic by absorption through skin.  Considered a mild skin
  irritant but not a skin sensitizer.
- Eye (rabbit)- A moderate irritant, with eyes normal within 7
CHRONIC STUDIES - Nicosulfuron
- Several studies have been conducted or are in progress to access the
  toxicity potential upon long-term dietary exposures to this active
  ingredient.  The data available are from 90-day to l-year dietary
  exposures of the mouse, rat and the dog.  There were no compound-
  related effects in rats exposed for one year.  Dogs were fed for l-
  year diets that contained 0, 250, 5,000 or 20,000 ppm.  No compound-
  related effects were observed in the females and although a decrease
  in body weight and increased mean liver weight was observed in males
  that received 20,000 ppm in the diet, there were no other compound
  effects observed.  The NOEL was judged to be 5,000 ppm for male dogs
  and 20,000 ppm for female dogs.
- Mice were fed for 90 days with diets that contained 0, 300, 1,500,
  7,500 and 10,000 ppm.  Equivocal effects, reduced counts for
  circulating neutrophils and monocytes, were observed in both sexes fed
  the 7,500 and 10,000 ppm diets and for female mice fed the 1,500 ppm
  diet.  However, these effects were not evident in preliminary data
  from a long-term study conducted at the same dietary concentrations.
  Other than reduced absolute spleen weights for females in the 10,000
  ppm group, there were no other effects observed.  The NOEL for this
  study was 300 ppm (44 and 62 mg/kg body wt/day for male and female
  mice, respectively).
- Reproductive and Development Studies:  Preliminary data from a study
  in rats, indicated that there were no effects on fertility, lactation
  indices or on offspring health at the highest dietary concentration,
  20,000.
- In studies to access teratogenicity and developmental toxicity,
  nicosulfuron was non-teratogenic and was not uniquely toxic to the
  unborn.  In the rat study, the NOEL for maternal and fetotoxcity was
  6,000 mg/kg body wt./day, the highest dose tested.  For the rabbit,
  the NOELs for maternal and fetotoxicity were 100 and 500 mg/kg/day,
  respectively.
- Mutagenicity and Genotoxicity:  Nicosulfuron was negative in each of
  five tests to determine its potential to produce mutagenic and
  genotoxic effects.  These tests include: Ames and in vitro
  cytogenetics in human lymphocytes; mouse micronuclei assay; and
  unscheduled DNA synthesis in rat hepatocytes.
HUMAN HEALTH EFFECTS:
- Human health effects of overexposure to nicosulfuron by eye contact
  may initially include eye irritation with discomfort, tearing, or
  blurring of vision.
- Repeated ingestion of high doses may produce reduced white blood cell
  production.
Carcinogenicity
   None of the components in this material is listed by IARC, NTP, OSHA, 
or ACGIH as a carcinogen.
Applicable Exposure Limits:
- Exposure Limits for Nicosulfuron
  - AEL * (Du Pont):  5 mg/m3 - 8- and 12-Hr. TWA, respirable dust
*  AEL is Du Pont's Acceptable Exposure Limit.
Safety Precautions
- Avoid contact with eyes, skin, or clothing. Wash thoroughly after
  handling.
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FIRST AID
- INHALATION:  No specific intervention is indicated as the compound is
  not likely to be hazardous by inhalation. Consult a physician if
  necessary.
- SKIN CONTACT:  In case of contact, immediately wash skin with soap and
  water. Wash contaminated clothing before reuse.
- EYE CONTACT:  In case of contact, immediately flush eyes with plenty
  of water for at least 15 minutes. Call a physician.
- INGESTION:  If swallowed, immediately give 2 glasses of water and
  induce vomiting. Never give anything by mouth to an unconscious
  person.  Call a physician.
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PROTECTION INFORMATION
Generally Applicable Control Measures and Procedures
- Do not consume food, drink or tobacco in the areas where they may
  become contaminated with this material.
Personal Protective Equipment
- Label instructions do not specify any PPE to be worn when handling
  this product.
- The protective equipment listed below is recommended for industrial
  handling and formulation.
- Wear safety glasses.  Wear coverall chemical splash goggles and face
  shield when the possibility exists for eye and face contact due to
  splashing or spraying of material.
- Wear protective clothing such as gloves, apron, boots or coveralls, as
  appropriate.
- Respiratory protection should not be required for normal use and
  handling.  During abnormal exposures, use of an approved pesticide
  respirator is recommended.
DISPOSAL INFORMATION
- Aquatic Toxicity :  Tests conducted with the active ingredient
  indicate low toxicity.
            Bluegill sunfish (96-hr) LC50 >1,000 ppm
            Rainbow trout    (96-hr) LC50 >1,000 ppm
            Daphnia magna    (48-hr) EC50 >1,000 ppm
- ENVIRONMENTAL TOXICITY:
            Oral LD50 Bobwhite Quail is > 2250 mg/kg.
            Dietary LC50 Bobwhite Quail is > 5620 ppm.
            Dietary LC50 Mallard Duck is > 5620 ppm.
- Spill, Leak, or Release
  NOTE: Review FIRE AND EXPLOSION HAZARDS and SAFETY PRECAUTIONS before
  proceeding with clean up. Use appropriate PERSONAL PROTECTIVE
  EQUIPMENT during clean up.  Shovel or sweep up.
- Waste Disposal
  Treatment, storage, transportation and disposal must be in accordance
  with applicable Federal, State/Provincial, and Local regulations.
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SHIPPING INFORMATION
- DOT
    Proper Shipping Name:
      Not regulated by D.O.T.
- DOT/IMO
    Proper Shipping Name:
      Not regulated
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STORAGE CONDITIONS
  Do not store or consume food, drink or tobacco in areas where they may
  become contaminated with this material.
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TITLE III HAZARD CLASSIFICATIONS
  Acute:      Yes
  Chronic:    No
  Fire:       No
  Reactivity: No
  Pressure:   No
ADDITIONAL INFORMATION AND REFERENCES
   This product is registered under EPA/FIFRA regulations.
   EPA Reg. No. is 352-534
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Date of latest Revision      : 06/26/90
Responsibility for MSDS  : Registration & Regulatory Aff., Agricultural
 Products, Wilmington, DE  19898