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prosulfuron (Exceed) NYSDEC Registration of Exceed Herbicide 2/96

New York State Department of Environmental Conservation
Division of Solid & Hazardous Materials
50 Wolf Road, Albany, New York 12233-7250
518-457-6934 FAX 518-457-0629
                                                   February 23, 1996
Mr. Jerry Harrison
State Registration and Regulatory Support
Ciba Crop Protection
P.O. Box 18300
Greensboro, NC 27419-8300
Dear Mr. Harrison:
Re:  Registration of the New Active Ingredient Prosulfuron; Contained in
     the Pesticide Product Exceed Herbicide (EPA Reg. No. 100-774)
     Ciba Crop Protection applied to New York State for registration of 
Exceed Herbicide (EPA Reg. No. 100-774) which contains the new active 
ingredient prosulfuron along with primisulfuron-methyl, the active 
ingredient found in Beacon Herbicide.
     Exceed Herbicide is a selective herbicide applied after emergence 
of both crop and weeds for the control of weeds in field corn, white 
corn, and popcorn. The water dispersible granule formulation contains 
28.5k prosulfuron and 28.5k primisulfuron-methyl. The maximum 
application rate of the product is 0.285 ounces (0.02 lb. or 8 g.) of 
prosulfuron per acre per year plus 0.285 ounces primisulfuron-methyl per 
acre per year. The product is to be applied once per season by ground 
equipment only and cannot be applied aerially or through any type of 
irrigation system.
     The New York State Department of Environmental Conservation (the 
Department) has completed review of the information supplied to date in 
support of the pesticide product registration application for Exceed 
Herbicide, which contains the new active ingredient prosulfuron.
     Exceed Herbicide is not toxic to mammals, birds, honeybees, 
freshwater fish and invertebrates, or saltwater fish and invertebrates. 
Laboratory studies indicate that prosulfuron is toxic to macrophytes. 
However, field studies indicate that prosulfuron will not remain in the 
environment long enough to cause toxicity to macrophytic vegetation. 
Neither prosulfuron nor the formulated product was very toxic in acute 
exposure studies by the oral, dermal or inhalation routes. They were 
slightly irritating to the eyes and skin, but were not reported to be 
skin sensitizers.
     Prosulfuron caused some toxic effects at relatively low doses in 
chronic animal studies. Although the United States Environmental 
Protection Agency (EPA) classifies the evidence of prosulfuron's 
oncogenicity as inadequate, the limited data available indicate that it 
may have some oncogenic potential. Given the low application rate of 
prosulfuron in Exceed Herbicide and the resulting low residues in foods, 
exposure of applicators and the general public to prosulfuron is 
expected to be very low.
     There are no chemical-specific federal or New York State drinking 
water/groundwater standards for prosulfuron. Based on its chemical 
structure, prosulfuron falls under the 50 micrograms per liter (ug/L) 
New York State drinking water standard for an "unspecified organic 
contaminant" (10 NYCRR Part 5 - Public Water Systems). This value of 50 
ug/L should also be considered a potential State groundwater standard.
     Exceed Herbicide should not impact groundwater in New York State 
when used according to label directions.
     Therefore, the Department hereby accepts for general use 
registration Exceed Herbicide (EPA Reg. No. 100-774). As a condition of 
this registration, however, we request a study summary and a copy of the 
EPA Data Evaluation Record (DER) report of the repeat rabbit 
developmental toxicity study with prosulfuron as soon as they are 
     Enclosed are your New York State stamped "ACCEPTED" label and a 
copy of the Certificate of Registration.
     Please contact Ms. Maureen Serafini, Supervisor of our Pesticide 
Product Registration Section, at (518) 457-7446, if you have any 
                              Norman H. Nosenchuck, P.E.
                              Division of Solid & Hazardous Materials
cc: w/enc.  N. Kim/A. Grey - NYS Dept. of Health
            N. Rudgers/R. Mungari - NYS Dept. of Agriculture and Markets
            D. Rutz/W. Smith - Cornell University