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aldoxycarb (Standak) EPA Pesticide Fact Sheet 1/86

                         EPA Pesticide Fact Sheet.

Name of Chemical:  Aldoxycarb

Reason for Issuance:  New Chemical Registration
Date Issued:  January 15, 1986
Fact Sheet Number:  115

1.  DESCRIPTION OF CHEMICAL

Generic Name:  2-methyl-2-(methylsulfonyl)propanal-O-(methylamino
               carbonyl oximel)

Common Name:  Aldoxycarb
Trade Name:  Standak
Other Names:  Sulfocarb, Aldicarb sulfure
EPA Shaughnessy Code:  110801
Chemical Abstracts Service (CAS) Number:  1646-88-4
Year of Initial Registration:  1986
Pesticide Type:  Insecticide/Nematicide
Chemical Family:  Carbamate

U.S. Producer:  Union Carbide Agricultural Products Co., Inc.
                No other producer at this time

2.  USE PATTERNS AND-FORMULATIONS

Application sites:  Containerized honey locust trees (Commercial Use Only) to 
control honey locust gall midge

Type of Formulations:  Insecticide/fertilizer spike; registered to 
International Spike, Inc.

Method of Application:  Spike is inserted into soil in container

Application Rate:  One or more spikes of 1% active ingredient per container, 
depending on size of container or plant.

Usual Carriers:  Formulation is a pressed mixture of aldoxycarb and fertilizer 
chemicals.

3.  SCIENCE FINDINGS

Summary Science Statement

Technical aldoxycarb has high mammalian acute toxicity. It has not been shown 
to cause oncogenic, mutagenic, teratogenic, delayed.neurotoxin or reproduction 
effects.  Aldoxycarb is a known degradate/metabolite of aldicarb produced by 
the oxidation of the thio-moiety.

Sufficient data are available to characterize aldoxycarb from an environmental 
fate and ecological standpoint.  Aldoxycarb is extremely toxic to wildlife. 
Use precautions are being imposed to reduce potential hazards.  Although 
aldoxycarb has the potential to contaminate groundwater under certain 
environmental conditions, the proposed containerized plant use will preclude 
any measurable contamination.

A tolerance assessment is not needed because the registered use pattern is for 
an ornamental plant.  There are no data gaps.

Chemical Characteristics of Technical Aldoxycarb

Physical State:  Crystalline powder at 20 degrees C
Color:  White
Odor:  Slightly sulfurous
Melting Point:  140-142  degrees C
Vapor Pressure:  9 x 10 to the minus 5 mm Hg at 25 degrees C
Density: l.35 9/cm cubed at 20 degrees C
ph:  3-6

Toxicology Characteristics of Technical Aldoxycarb

Acute oral:  21.4 mg/kg, Toxicity Category I
Acute dermal:  1000 mg/kg, Toxicity Category II
Primary Dermal Irritation:  No irritation, Toxicity Category III
Primary Eye Irritation:  No irritation, Toxicity Category IV
Acute Inhalation:  O.209 mg/l, Toxicity Category II.

Neurotoxicity:  Not an acute delayed neurotoxic agent at doses up to 250 mg/kg 
(highest dose tested (HDT)).

Oncogenicity:  Two studies, rat and mouse.  Both are acceptable and are 
negative for oncogenic effects up to 9.6 mg/kg/day (HDT).

Teratogenicity:  Two teratology studies, rat and rabbit have been evaluated to 
determine the teratogenic potential of aldoxycarb.  Both studies were negative 
for teratogenic effects at levels up to 9.6 mg/kg (HDT).

Reproduction/3-generation:  No effects on reproduction at levels up to 9.6 
mg/kg (HDT).

Metabolism:  The metabolism of aldoxycarb is adequately understood.  It is 
metabolized by hydrolysis of the carbamate ester to form the oxime.  Other 
reactions of the oxime occur.

Mutagenicity:  Adequate studies are available to demonstrate aldoxycarb is not 
a mutagen.

Physiological and Biochemical Behavioral Characteristics

Mechanism of Pesticidal Action:  A systemic insecticide/nematicide which 
causes reversible carbamalation of the acetocholinesterase enzyme of tissues, 
allowing accumulation of acetylcholine at cholinergic neuroeffector junctions 
(muscarinic effects) and at skeletal muscle myoneural junctions and in 
autonomic ganglia (nicotinic effects).  The central nervous system is also 
impaired.

Symptoms of poisoning include:  headache, dizziness, weakness, ataxia, 
pinpoint pupils, blurred or dark vision, muscle twitching, nausea, vomiting, 
diarrhea, convulsions and death.  The onset of these symptoms is rapid and 
their severity depends on the dose.  The immediate cause of death is usually 
respiratory failure.

Metabolism and Persistence in Plants and Animals:  Acceptable studies have 
been submitted which show aldoxycarb is metabolized in plants and animals by 
hydrolysis of the carbamate ester to form the oxime.  Further reactions of the 
oxime yield aldoxycarb aldehyde, aldoxycarb alcohol, aldoxycarb acid and 
aldoxycarb nitrile.  The oxime and alcohol metabolites are easily conjugated 
to form water soluble glycosides, sulfates, and other compounds.

Environmental Characteristics

In soil and water, aldoxycarb is very stable under acidic conditions, stable 
at neutral conditions and very unstable to hydrolysis at alkaline conditions.  
It is rapidly hydrolyzed to sulfocarb oxime which in turn rapidly degrades to 
methane sulfonic acid and 2-hydroxy isobutryraldehyde oxime. Aldoxycarb is 
rapidly degraded to a variety of materials under both aerobic and anaerobic 
conditions.  In certain soils, such as those with a sandy loam texture, it has 
a half-life of 2-4 weeks.  Aldoxycarb is mobile in certain soil types and does 
have the potential to contaminate groundwater under certain situations.  Soil 
types of high sand content and organic matter will promote leaching of parent 
and degradation products, which are of lower toxicity than that of the parent 
compound.

However, it is believed the containerized ornamental plant use will not result 
in groundwater contamination because of the fact that application is made to 
soils in containers.

Ecological Effects of Technical Aldoxycarb

Avian oral:  Mallard duck - 33.5 mg/kg
Avian dietary:  Waterfowl species (Mallard duck) - <10,000 ppm
                Upland game species (Bobwhite quail) - 5,706 ppm
Freshwater fish:  Coldwater species (rainbow trout) - 42.0 ppm
                  Warmwater species (bluegill sunfish) - 53.0 ppm
Acute Freshwater Invertebrates:  Daphnia - 0.176 ppb
Precautionary language would be required for outdoor terrestrial use for 
   hazards to wildlife.

4.  SUMMARY OF REGULATORY POSITION AND RATIONALE

The Agency has determined to register aldoxycarb for containerized ornamental 
plants because, adequate studies are available to assess the toxicological and 
environmental characteristics of aldoxycarb and its potential effects to 
humans from this use.  The Agency concludes from this study that this use 
pattern will not pose any unreasonable adverse effects to humans or the 
environment.  None of the criteria for unreasonable adverse effects listed in 
section 162.11(a) of Title 40 of the U.S. Code of Federal Regulations have 
been. met or exceeded for this use.

5.  SUMMARY OF MAJOR DATA GAPS

There are no data gaps.

6.  CONTACT PERSON AT EPA

Jay S. Ellenberger
Product Manager (12)
Insecticide-Rodenticide Branch
Registration Division (TS-767C)
Office of Pesticide Programs,
Environmental Protection Agency,
401 M St., S.W.
Washington, D.C. 20460.

Office location and telephone number:
Rm. 202, Crystal Mall Bldg. 2
1921 Jefferson Davis Highway,
Arlington, VA 22202,
(703) 557-2386.

DISCLAIMER:  The information presented in this Chemical Information Fact sheet 
is for informational purposes only and may not be used to fulfill data 
requirements for pesticide registration and reregistration.