aldoxycarb (Standak) EPA Pesticide Fact Sheet 1/86
EPA Pesticide Fact Sheet.
Name of Chemical: Aldoxycarb
Reason for Issuance: New Chemical Registration
Date Issued: January 15, 1986
Fact Sheet Number: 115
1. DESCRIPTION OF CHEMICAL
Generic Name: 2-methyl-2-(methylsulfonyl)propanal-O-(methylamino
Common Name: Aldoxycarb
Trade Name: Standak
Other Names: Sulfocarb, Aldicarb sulfure
EPA Shaughnessy Code: 110801
Chemical Abstracts Service (CAS) Number: 1646-88-4
Year of Initial Registration: 1986
Pesticide Type: Insecticide/Nematicide
Chemical Family: Carbamate
U.S. Producer: Union Carbide Agricultural Products Co., Inc.
No other producer at this time
2. USE PATTERNS AND-FORMULATIONS
Application sites: Containerized honey locust trees (Commercial Use Only) to
control honey locust gall midge
Type of Formulations: Insecticide/fertilizer spike; registered to
International Spike, Inc.
Method of Application: Spike is inserted into soil in container
Application Rate: One or more spikes of 1% active ingredient per container,
depending on size of container or plant.
Usual Carriers: Formulation is a pressed mixture of aldoxycarb and fertilizer
3. SCIENCE FINDINGS
Summary Science Statement
Technical aldoxycarb has high mammalian acute toxicity. It has not been shown
to cause oncogenic, mutagenic, teratogenic, delayed.neurotoxin or reproduction
effects. Aldoxycarb is a known degradate/metabolite of aldicarb produced by
the oxidation of the thio-moiety.
Sufficient data are available to characterize aldoxycarb from an environmental
fate and ecological standpoint. Aldoxycarb is extremely toxic to wildlife.
Use precautions are being imposed to reduce potential hazards. Although
aldoxycarb has the potential to contaminate groundwater under certain
environmental conditions, the proposed containerized plant use will preclude
any measurable contamination.
A tolerance assessment is not needed because the registered use pattern is for
an ornamental plant. There are no data gaps.
Chemical Characteristics of Technical Aldoxycarb
Physical State: Crystalline powder at 20 degrees C
Odor: Slightly sulfurous
Melting Point: 140-142 degrees C
Vapor Pressure: 9 x 10 to the minus 5 mm Hg at 25 degrees C
Density: l.35 9/cm cubed at 20 degrees C
Toxicology Characteristics of Technical Aldoxycarb
Acute oral: 21.4 mg/kg, Toxicity Category I
Acute dermal: 1000 mg/kg, Toxicity Category II
Primary Dermal Irritation: No irritation, Toxicity Category III
Primary Eye Irritation: No irritation, Toxicity Category IV
Acute Inhalation: O.209 mg/l, Toxicity Category II.
Neurotoxicity: Not an acute delayed neurotoxic agent at doses up to 250 mg/kg
(highest dose tested (HDT)).
Oncogenicity: Two studies, rat and mouse. Both are acceptable and are
negative for oncogenic effects up to 9.6 mg/kg/day (HDT).
Teratogenicity: Two teratology studies, rat and rabbit have been evaluated to
determine the teratogenic potential of aldoxycarb. Both studies were negative
for teratogenic effects at levels up to 9.6 mg/kg (HDT).
Reproduction/3-generation: No effects on reproduction at levels up to 9.6
Metabolism: The metabolism of aldoxycarb is adequately understood. It is
metabolized by hydrolysis of the carbamate ester to form the oxime. Other
reactions of the oxime occur.
Mutagenicity: Adequate studies are available to demonstrate aldoxycarb is not
Physiological and Biochemical Behavioral Characteristics
Mechanism of Pesticidal Action: A systemic insecticide/nematicide which
causes reversible carbamalation of the acetocholinesterase enzyme of tissues,
allowing accumulation of acetylcholine at cholinergic neuroeffector junctions
(muscarinic effects) and at skeletal muscle myoneural junctions and in
autonomic ganglia (nicotinic effects). The central nervous system is also
Symptoms of poisoning include: headache, dizziness, weakness, ataxia,
pinpoint pupils, blurred or dark vision, muscle twitching, nausea, vomiting,
diarrhea, convulsions and death. The onset of these symptoms is rapid and
their severity depends on the dose. The immediate cause of death is usually
Metabolism and Persistence in Plants and Animals: Acceptable studies have
been submitted which show aldoxycarb is metabolized in plants and animals by
hydrolysis of the carbamate ester to form the oxime. Further reactions of the
oxime yield aldoxycarb aldehyde, aldoxycarb alcohol, aldoxycarb acid and
aldoxycarb nitrile. The oxime and alcohol metabolites are easily conjugated
to form water soluble glycosides, sulfates, and other compounds.
In soil and water, aldoxycarb is very stable under acidic conditions, stable
at neutral conditions and very unstable to hydrolysis at alkaline conditions.
It is rapidly hydrolyzed to sulfocarb oxime which in turn rapidly degrades to
methane sulfonic acid and 2-hydroxy isobutryraldehyde oxime. Aldoxycarb is
rapidly degraded to a variety of materials under both aerobic and anaerobic
conditions. In certain soils, such as those with a sandy loam texture, it has
a half-life of 2-4 weeks. Aldoxycarb is mobile in certain soil types and does
have the potential to contaminate groundwater under certain situations. Soil
types of high sand content and organic matter will promote leaching of parent
and degradation products, which are of lower toxicity than that of the parent
However, it is believed the containerized ornamental plant use will not result
in groundwater contamination because of the fact that application is made to
soils in containers.
Ecological Effects of Technical Aldoxycarb
Avian oral: Mallard duck - 33.5 mg/kg
Avian dietary: Waterfowl species (Mallard duck) - <10,000 ppm
Upland game species (Bobwhite quail) - 5,706 ppm
Freshwater fish: Coldwater species (rainbow trout) - 42.0 ppm
Warmwater species (bluegill sunfish) - 53.0 ppm
Acute Freshwater Invertebrates: Daphnia - 0.176 ppb
Precautionary language would be required for outdoor terrestrial use for
hazards to wildlife.
4. SUMMARY OF REGULATORY POSITION AND RATIONALE
The Agency has determined to register aldoxycarb for containerized ornamental
plants because, adequate studies are available to assess the toxicological and
environmental characteristics of aldoxycarb and its potential effects to
humans from this use. The Agency concludes from this study that this use
pattern will not pose any unreasonable adverse effects to humans or the
environment. None of the criteria for unreasonable adverse effects listed in
section 162.11(a) of Title 40 of the U.S. Code of Federal Regulations have
been. met or exceeded for this use.
5. SUMMARY OF MAJOR DATA GAPS
There are no data gaps.
6. CONTACT PERSON AT EPA
Jay S. Ellenberger
Product Manager (12)
Registration Division (TS-767C)
Office of Pesticide Programs,
Environmental Protection Agency,
401 M St., S.W.
Washington, D.C. 20460.
Office location and telephone number:
Rm. 202, Crystal Mall Bldg. 2
1921 Jefferson Davis Highway,
Arlington, VA 22202,
DISCLAIMER: The information presented in this Chemical Information Fact sheet
is for informational purposes only and may not be used to fulfill data
requirements for pesticide registration and reregistration.