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arosurf MSF Chemical Fact Sheet 2/84





CHEMICAL FACT SHEET FOR:  AROSURF MSF

FACT SHEET NUMBER:  17

DATE ISSUED:  FEBRUARY 15, 1984

                        1. DESCRIPTION OF CHEMICAL

- Generic Name:  Poly(oxy-1,2-ethanediyl), alpha-isooctadecyl-omegahydroxy
- Common Name:  None 
- Trade Name:  Arosurf MSF (Monomolecular Surface Film) 
- EPA Shaughnessy Code:  124601 
- Chemical Abstracts Service (CAS) Number:  52292-17-8 
- Year of Initial Registration:  1984 
- Pesticide Type:  Insecticide (mosquito larvacide/pupacide) 
- Chemical Family:  Ethoxylated Fatty Alcohol (a non-ionic surfactant) 
- U.S. Producer:  Sherex Chemical Company, Inc.

                  2. USE PATTERNS AND FORMULATIONS

- Application sites:  Semi-permanent or permanent fresh (including potable and
  irrigation sources) or salt water habitats. Semipermanent or permanent
  polluted water habitats.
- Types of formulations:  liquid
- Types and methods of application:  ground and air spray
- Application rates:  3-5 gal/acre (i.e., 0.2-0.5 gal. a.i./acre
- Usual carriers:  water
- Efficacy review results:  Efficacy data not required

                        3. SCIENCE FINDINGS

Chemical Characteristics:

Arosurf MSF is a clear, light amber liquid at 77 degrees F, with a melting 
point of 19-27 degrees F and a flash point of 395 degrees F. It is capable of 
reducing the surface tension of clean water to 28.2 dyns/cm at 77 degrees F. 
As a surfactant, it forms a film over the surface of the water to which it is 
applied. Its mode of action is considered to be physical rather than chemical 
in that it reduces the water surface tension, resulting in suffocation of the 
larvae and pupae.

Toxicological Characteristics:

Arosurf MSF demonstrates low toxicity (Tox Category III) from the following 
submitted studies: 

- Two oral LD50 rat studies:  20 gm/kg and 5.0 gm/kg 
- Eye irritation, rabbit:  not an eye irritant 
- Primary eye irritation, rabbit:  not an eye irritant 
- Acute LC50 inhalation, rat:  >29 mg/L 
- Salmonella microsomal Ames mutagenicity assay:  negative
- Primary skin irritation, guinea pig:  mild dermal irritant
- Primary skin irritation, rabbit:  severe dermal irritant with
  reversibility of effect
- Primary skin irritation, human patch test:  not a skin irritant
- 2-year dog study with a NOEL of 50,000 ppm (1250 mg/kg)
- Two 2-year dog studies with NOEL of 20,000 ppm (1,000 mg/kg)
- 10-month monkey study with a NOEL of 1,000 mg/day

Physiological and Biochemical Behavioral Characteristics

- Foliar absorption:  N/A
- Translocation:  N/A
- Mechanism of pesticidal action: suffocation (physical)
- Metabolism and persistence in plants and animals:  N/A

Environmental Characteristics:

- Adsorption and leaching in basic soil types:  N/A
- Microbial breakdown: data show that the chemical is degraded by
  unacclimated, mixed cultures from natural sources by the shake culture
  method.
- Loss from photodecomposition and/or volatilization: Arosurf MSF is
  stable to hydrolysis and aqueous photolysis in the absence of 
  photosensitizers. 
- Bioaccumulation: Similar alcohol ethoxylates degrade under field
  conditions, with the major route of degradation being hydrolysis at the
  ether linkage and subsequent oxidation of the alkyl chain to lower molecular
  weight polyethylene glycol-like materials and ultimately C02 and H20. 
- Resultant average persistence: 2 to 10 days at recommended dosage
rates.

Ecological Characteristics

- Hazards to fish and wildlife: the following data have been submitted: 
  - Avian acute oral LD5O (mallard duck):  >2,000 mg/kg 
  - Avian dietary LC50 (bobwhite quail):  >5,000 mg/kg 
  - Fish acute LC50 (bluegill):  290 mg/L; and rainbow trout:  98 mg/L 
  - Aquatic invertebrate LC50 (Daphnia):  1.9 mg/L

Tolerance Assessments

- An exemption from the requirement of a tolerance for the pesticide in or on
  fish, shellfish, irrigated crops, meat, milk, poultry, and eggs, when used
  as a mosquito control agent in aquatic areas, has been established under 
  40 CFR 180.1078. 
- Studies on closely related fatty acid and fatty alcohol ethoxylates having
  various degrees of ethoxylation supported the clearance of the chemical as
  an inert ingredient and were also used in support of the exemption as an
  active ingredient.

- Summary Science Findings

Based on submitted toxicity and fish and wildlife data, Arosurf demonstrates 
low toxicity to humans, fish, and wildlife.  The product is conditionally 
registered pending the submission of additional fish and wildlife studies.

             4. SUMMARY OF REGULATORY POSITION AND RATIONALE

- Use classification:  General 
- Use, formulation, manufacturing process, or geographical restrictions:  None
- Unique warning statements required on labeling:  None
- Summary of risk/benefit review:  None conducted
- It has been determined that (1) the use of Arosurf MSF has met the public
  interest finding as required for the conditional registration of a new
  chemical under section 3(c)(7)(C) of FIFRA, as amended; and (2) that the use
  of the pesticide during the period in which the requested data is being
  generated will not cause any unreasonable adverse effect on the environment.

                     5. SUMMARY OF MAJOR DATA GAPS

- One avian dietary study on mallard duck (submitted and currently under
  review)
- One fish early lifestage study
- One aquatic invertebrate (Mysid shrimp) life cycle study

NOTE: These studies are to be submitted no later than February 1, 1987.

                         6. CONTACT PERSON AT EPA

William H. Miller
Product Manager (16)
Insecticide-Rodenticide Branch
Registration Division (TS-767)
Environmental Protection Agency
Washington, DC 20460

(703) 557-2600


DISCLAIMER:
THE INFORMATION PRESENTED IN THIS CHEMICAL INFORMATION FACT SHEET IS FOR 
INFORMATIONAL PURPOSES ONLY AND NOT TO BE USED TO FULFILL DATA REOUIREMENTS 
FOR PESTICIDE REGISTRATION AND REREGISTRATION.