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bendiocarb (Ficam) Chemical Profile 4/85

                                  bendiocarb

      CHEMICAL NAME:      2,2-Dimethyl-1,3-benzodioxol-4-yl methylcarbamate
                          (56)

      DEC INGRED. CODE:

      TRADE NAME(S):      Ficam (56)

      FORMULATION(S):     76% wettable powder, 1% dust; 25% oil suspension for
                          ULV application, 10 granule, and 29% WP plus
                          pyrethrins and piperonyl butoxide (56).

      TYPE:               Carbamate insecticide

      BASIC PRODUCER(S):  Fisons Incorporated
                          Agricultural Chemicals Division
                          2 Preston Court
                          Bedford, MA 01730

      STATUS:             Restricted use

      PRINCIPAL USES:  For the control of cockroaches and crickets, carpet
      beetles, earwigs, ants, silverfish, wasps, fleas, brown dog ticks,
      etc., in foodstores, houses, and other buildings by professional
      applicators.  Also for control of pests in turf and ornamentals (56).


                                I.  EFFICACY

      a.   Cockroaches:   Bendiocarb is 2-10 times more effective than other
           insecticides to German cockroaches (Blatella germanica).  LC50 (%
           w/v) = 0.0146 as contact spray.

      b.   Mosquitoes:  Bendiocarb shows very high activity as a mosquito
           adulticide.  In surface contact tests on filter paper, bendiocarb
           has an LC50 to adult female Aedes aegypti of 1 mg/m2 and an LC50
           to adult female Culex pipiens quinquefasciatus of 10.9 mg/m2
           compared to 48 mg/m2 for propoxur.

      c.   Ants:  In surface contact tests involving two species of ants,
           bendiocarb showed higher activity than propoxur and chlordane.
           Against both species (Monomorium pharaonis, pharoah's ant; Lasium
           niger, black ant) bendiocarb was fully effective at rates of 0.3
           mg ai/m2.

      d.   Carpet beetles:  Bendiocarb has excellent activity against larvae
           of 2 species of carpet beetles exposed to woolen cloth treated
           with solutions of bendiocarb in acetone.

                Species                                           LC50
                _______                                           ____

      Anthrenus flavipes (larvae)                            25 ppm (approx.)
      Attagenus megatoma (larvae)                           100 ppm (approx.)
      Attagenus megatoma (adult)                              4 mg/m2

      Knockdown:  Bendiocarb gives quicker knockdown of insects than most
      other residual insecticides, but is slower than dichlorvos or
      pyrethrin.  Time in minutes to achieve 50% knockdown of male Blattella
      germanica = 8.

                               Rate of use             Time (mins) to achieve
         Insect              on Glass Plates              100% knockdown
         ______              _______________              ______________

      Black ant              100 mg ai/m2                       4
      Black ant                1 mg ai/m2                      15
      Pharaoh's Ant            1 mg ai/m2                       9

           In laboratory experiments FICAM W gave a longer residual control of
      susceptible, Malathion-resistant, and Diazinon-resistant strains of
      Blattella germanica than Chlordane, Diazinon, Malathion, or Baygon (all
      27).
           Rapid knockdown with good residual activity.  Ten weeks control can
      be expected.  Has no smell and does not stain the treated surface (8a).


                           II.  PHYSICAL PROPERTIES

      MOLECULAR FORMULA:   C11 H13 NO4 (62)

      MOLECULAR WEIGHT:    223.2 (62)

      PHYSICAL STATE:      Colorless solid (pure compound) (62)

      ODOR:                Nil or very slight (27)

      MELTING POINT:       129-130 C (pure compound) (62)

      VAPOR PRESSURE:      660 uPa at 25 C (pure compound) (62)

      SOLUBILITY:          40 mg/l water at 25 C (pure compound) (62)


                        II.  HEALTH HAZARD INFORMATION

      OSHA STANDARD:  None established

      NIOSH RECOMMENDED LIMIT:  None established

      ACGIH RECOMMENDED LIMIT:  None established

      TOXICOLOGY

           A.  ACUTE TOXICITY

               DERMAL:  LD50 = 566-600 mg/kg (rat) (62)
                        Not a skin irritant (27)
                        LD50 = >1000 mg/kg (rat, 76 WP formulation) (56).

               ORAL:    LD50 is in the range 40-156 mg/kg; other mammals
                          respond similarly (62).
                        LD50 = 179 mg/kg (rat, 76 WP formulation) (56)

               EYES:    Ficam W sprays do not irritate the eye.  However,
                        aqueous suspensions of Ficam W induce pupillary
                        contraction, lasting 1-2 hours in the rabbit eye (27).

           B.  SUBACUTE AND CHRONIC TOXICITY:

           In 2-yr feeding trials NEL for rats was 10 mg/kg diet; in 90-day
      trials rats receiving 250 mg/kg diet showed no visible toxic effects
      (62).


                     IV.  ENVIRONMENTAL CONSIDERATIONS

           LC50 (96-hr) for rainbow trout is 1.55 mg/l.  Toxic to honeybees,
      LD50 0.1 ug/bee (62).
           Little or no hazard to birds, fish, and beneficial insects.
      Biological magnification unlikely.  Nonphytotoxic (1).
           Soil studies in both aerobic and anaerobic conditions indicate
      breakdown of the parent compound to nontoxic metabolites (27).
           Toxicity to birds is similar to toxicity to small mammals.  Ficam W
      is highly toxic to fish.  Avoid contamination of aquaria.  LC50 for
      bluegill is 1.76 ppm ai and for rainbow trout 0.70 ppm ai.  Ficam W is
      highly toxic to beneficial insects.  Care must be taken to prevent
      contamination of flowering vegetation (28a).

      Approximate Residual Period:  Several weeks on inert surfaces; foliage
      residues break down rapidly (1).


                    V.  EMERGENCY AND FIRST AID PROCEDURES

           The chemical information provided below has been condensed
      from original source documents, primarily from "Recognition and
      Management of Pesticide Poisonings", 3rd ed. by Donald P. Morgan,
      which have been footnoted.  This information has been provided in
      this form for your convenience and general guidance only.  In
      specific cases, further consultation and reference may be required
      and is recommended.  This information is not intended as a sub-
      stitute for a more exhaustive review of the literature nor for the
      judgement of a physician or other trained professional.

           If poisoning is suspected, do not wait for symptoms to develop.
      Contact a physician, the nearest hospital, or the nearest Poison
      Control Center.

      FREQUENT SYMPTOMS AND SIGNS OF POISONING BY CARBAMATE PESTICIDES

           DIARRHEA, NAUSEA, VOMITING, ABDOMINAL PAIN, PROFUSE SWEATING,
      SALIVATION, and BLURRED VISION are frequently reported.  Other common
      symptoms have been dyspnea, tremor, muscle twitching, ataxia, and
      headache.  Temporary paralysis of the extremities has also occurred.
      Most reported illnesses have not exceeded a few hours, and the
      prognosis is generally better than in organophosphate intoxications.
      However, in severe poisonings, one should anticipate the possibility of
      RESPIRATORY DEPRESSION, pulmonary edema, and convulsions.  Continuing
      absorption of intermediate quantities may cause protracted MALAISE,
      weakness, and anorexia, resembling influenza (25).

           SKIN CONTACT:  Wash with soap and water (25).

           INGESTION:  If victim is alert and respiration is not depressed,
      give Syrup of Ipecac, followed by 1-2 glasses of water to induce
      vomiting; adults, 30 ml; children (under 12 years), 25 ml (25).

      NOTES TO PHYSICIAN:

      Administer ATROPINE SULFATE intravenously, or intramuscularly if IV
      injection is not possible.
      In MODERATELY SEVERE poisoning:  Adult dosage:  0.4-2.0 mg repeated
      every 15 minutes until atropinization is achieved (tachycardia,
      flushing, dry mouth, mydriasis).  Maintain atropinization by repeated
      doses for 2-12 hours, or longer, depending on severity of poisoning.
      Dosage for children under 12 years:  0.05 mg/kg body weight repeated
      every 15 minutes until atropinization is achieved.  Maintain
      atropinization with repeated dosage of 0.02-0.05 mg/kg.
      SEVERELY POISONED individuals may exhibit remarkable tolerance to
      atropine; twice the doses suggested above may be needed.
      Pralidoxime (Protopam (TM)-Ayerst, 2-PAM) is of doubtful value in
      poisonings by carbamate inhibitors of cholinesterase.  Atropine alone
      is almost always an adequate antidote (25).


                     VI.  FIRE AND EXPLOSION INFORMATION

           To be developed.


                              VII.  COMPATIBILITY

           Ordinarily not mixed with other materials.  Do not use with oil (1).


                           VIII.  PROTECTIVE MEASURES

      STORAGE AND HANDLING:  Harmful or fatal if swallowed.  May be absorbed
      through skin.  Avoid contact with eyes, skin, and clothing.  Avoid all
      contact by mouth; avoid working in spray mist; wash hands and exposed
      skin before eating, drinking or smoking after work.  Do not store near
      feed or food products.  Remove or cover all foodstuffs before
      application; protect food preparing equipment, surfaces, and eating
      utensils from contamination during application (56).

      PROTECTIVE CLOTHING:  Wear rubber or PVC gloves and face shield when
      handling concentrate (56).


                               X.  LITERATURE CITED

       1.  Harding, W.C.  1979.  Pesticide profiles, part one: insecticides
               and miticides.  Univ. Maryland, Coop. Ext. Serv. Bull. 267.
               30 pp.

       8a. Thomson, W. T.  1976.  Agricultural chemicals - book 1:
               insecticides, acaricides, and ovicides.  Revised ed.  Thomson
               Publ., Indianapolis, IN.  232 pp.

      25.  Morgan, D.P.  1982.  Recognition and management of pesticide
               poisonings, 3rd ed.  U.S. Environmental Protection Agency,
               Washington, DC.  120 pp.

      27.  Fisons Incorporated.  1977.  Ficam pest control manual.  Bedford,
               MA.

      28a. Velsicol Chemical Corporation, Commercial Development Department.
               1976.  Technical information:  Ficam W insecticide.  Chicago,
               IL.

      56.  Farm Chemicals Handbook, 70th ed.  1984.  R. T. Meister, G. L.
               Berg, C. Sine, S. Meister, and J. Poplyk, eds.  Meister
               Publishing Co., Willoughby, OH.

      62.  The Pesticide Manual:  A World Compendium, 7th ed.  1983.  C.R.
               Worthing, ed.  The British Crop Protection Council, Croydon,
               England.  695 pp.

      4/26/85