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chlordimeform (Galecron, Fundal) Chemical Profile 5/85

                                chlordimeform

      CHEMICAL NAME:      N'-(4-Chloro-O-tolyl)-N,N-dimethyl-formamidine (74)

      DEC INGRED. CODE:

      TRADE NAME(S):      Galecron, Fundal (74)

      FORMULATION(S):     Emulsifiable concentrates (4 pounds/gallon); water
                          soluble powder (SP) (hydrochloride salt) (74)

      TYPE:               Formamidine derivative insecticide-miticide

      BASIC PRODUCER(S):  Ciba-Geigy Corp.
                          Agricultural Division
                          P. O. Box 18300
                          Greensboro, NC 27419

      STATUS:             Restricted use

      PRINCIPAL USES:  Chlordimeform is effective as an ovicide/insecticide
      for control of bollworm and tobacco budworm in cotton.  Effective also
      for the control of resistant mites and their eggs, and many
      lepidopterous insect pests but not on current U.S. label (74).


                                I.  EFFICACY

      Important Pests Controlled:  Mites, loopers, bollworms, cotton leaf
      perforators, codling moth, twig borers, pear psylla, leafrollers and
      others (8a).
           This product has exceptionally good ovicidal activity.  More
      effective on mite eggs and larvae than the adults.  Requires 24-96 hours
      for mite control.  Does not have good knockdown ability on full grown
      worms.  Prevents eggs from hatching (8a).


                           II.  PHYSICAL PROPERTIES

      MOLECULAR FORMULA:  C10 H13 ClN2 (62)

      MOLECULAR WEIGHT:   196.7 (62)

      PHYSICAL STATE:     Colorless crystals (pure compound); the
                          technical grade is >96% pure (62).

      MELTING POINT:      32 C (pure compound) (62)

      BOILING POINT:      163-165 C/14 mmHg (pure compound) (62)

      VAPOR PRESSURE:     48 mPa at 20 C (pure compound) (62)

      SOLUBILITY:         250 mg/l water at 20 C (pure compound) (62)


                        III.  HEALTH HAZARD INFORMATION

      OSHA STANDARD:  None established

      NIOSH RECOMMENDED LIMIT:  None established

      ACGIH RECOMMENDED LIMIT:  None established

      TOXICOLOGY

           A.  ACUTE TOXICITY

               DERMAL:  LD50 = 640 mg/kg (rat, for base); >4000 mg/kg (rabbit,
                          for hydrochloride (Fundal SP)); 2500 mg/kg, skin
                          irritation moderate (rabbit, for Galecron 4E, Fundal
                          4EC and Bermat 50%) (74).
                        Skin irritation slight (rabbit, hydrochloride) (62).

               ORAL:    LD50 = 340 mg/kg (rat, for base); 355 mg/kg (rat, for
                          hydrochloride (Fundal SP)); 250 mg/kg (rat, for
                          Galecron 4E, Fundal 4EC and Bermat 50%) (74).
                        LD50 = 625 mg chlordimeform/kg (rabbit) (62)

               INHALATION:  LD50 = 3.3 mg/l for 4 hours (rat, for Galecron
                            4E, Fundal 4EC and Bermat 50%) (74).

               EYES:    Severe irritation (rabbit, for Galecron 4E, Fundal 4
                          EC, and Bermat 50%) (74).
                        Studies with rabbits have shown eye irritation and
                          redness and swelling of the eyelids can occur
                          (Galecron 4E) (24c).
                        Galecron SP:  minimally irritating on contact.
                          Studies with rabbits have shown slight redness or
                          swelling of the eyelids can occur (24b).

           B.  SUBACUTE AND CHRONIC TOXICITY:

           Long-term studies have shown chlordimeform to be an oncogen
      (causes tumors) in mice (24b,c).
           In 2-yr. feeding trials NEL was: for rats 0.1 mg/kg daily; for dogs
      6.25 mg/kg daily (62).


                     IV.  ENVIRONMENTAL CONSIDERATIONS

           LC50 (24-hr) is: for trout 11.7 mg/l; for bluegill 1 mg/l; LC50
      (48-hr) for Japanese killifish 33 mg/l.  It is non-toxic to honeybees
      (62).  Toxic to fish (8a).


                  V.  EMERGENCY AND FIRST AID PROCEDURES

           The chemical information provided below has been condensed
      from original source documents, primarily from "Recognition and
      Management of Pesticide Poisonings", 3rd ed.  by Donald P. Morgan,
      which have been footnoted.  This information has been provided in
      this form for your convenience and general guidance only.  In
      specific cases, further consultation and reference may be required
      and is recommended.  This information is not intended as a sub-
      stitute for a more exhaustive review of the literature nor for the
      judgement of a physician or other trained professional.

           If poisoning is suspected, do not wait for symptoms to develop.
      Contact a physician, the nearest hospital, or the nearest Poison
      Control Center.

      SYMPTOMS

           Chlordimeform can cause acute illness and urinary bladder
      irritation.  Principal symptoms are dysuria, gross hematuria, urethral
      discharge, abdominal and back pain, and a hot sensation all over.
      Sleepiness, skin rash, anorexia, and a sweet taste in the mouth have
      also been reported.  Cystoscopic examination of victims of excessive
      exposure demonstrated acute hemorrhagic cystitis (25).

           SKIN CONTACT:  Immediately remove contaminated clothing, wiping
      away excess material from the skin.  Wash with plenty of soap and
      water.  Do not attempt to neutralize with chemical agents.  Obtain
      medical advice (24b,c).

           INGESTION:  Galecron 4E:  Do NOT induce vomiting.  Never give
      anything by mouth to an unconscious person.  Give water to drink and call
      a physician or the nearest Poison Control Center immediately (24c).
           Galecron SP:  Immediately give large quantities of water to drink
      and induce vomiting.  Never give anything by mouth to an unconscious
      person.  Call a physician or the nearest Poison Control Center
      immediately (24b).

           INHALATION:  Remove from contaminated atmosphere.  If symptoms
      appear or person is unconscious, get medical attention (24b,c).

           EYE CONTACT: Immediately flush the eyes with large amount of
      running water for a minimum of 15 minutes.  Hold the eyelids apart during
      the flushing to ensure rinsing of the entire surface of the eye and lids
      with water.  Do not attempt to neutralize with chemical agents.  Obtain
      medical attention (24b,c).

      NOTES TO PHYSICIAN:

           Symptoms resulting from undue occupational exposure resolve in a
      few days if exposure is terminated.  If chlordimeform has been recently
      ingested, it should be removed from the gut either by administering
      Syrup of Ipecac, or by gastric intubation, aspiration, and lavage with
      0.9% sodium chloride, followed by activated charcoal and sodium sulfate
      cathersis.  Serial urinanalyses should be performed to assess injury to
      the urinary tract (25).


                      VI.  FIRE AND EXPLOSION INFORMATION

      GENERAL:  Fire hazard: none.  Hazardous decomposition product: 2-amino-5-
      chlorotoluene.  As in any fire, prevent human exposures to fire, smoke,
      fumes or products of combustion.  Evacuate nonessential personnel from
      the area.  Firefighters should wear impervious clothing such as nitrile
      gloves, and neoprene hoods, suits and rubber boots (24b,c).

      EXTINGUISHER TYPE:  Use standard chemical firefighting techniques in
      extinguishing fires involving this material -- use dry chemicals, foam
      or carbon dioxide (24b,c).


                            VII.  COMPATIBILITY

           Compatible with most other pesticides.  Do not mix with alkaline
      materials (8a).


                          VIII.  PROTECTIVE MEASURES

      STORAGE AND HANDLING:  Shelf-life of at least 3 to 5 years when stored
      in a dry place and minimum storage temperatures (above 32 F) are
      observed.  Do not get in eyes, on skin, or clothing.  Do not breathe
      mist; keep container closed.  Wash thoroughly after handling.  Do not
      contaminate food or feed products.  Fundal 4EC:  Do not store below 0 C
      (74).

      PROTECTIVE CLOTHING:  When handling and applying chlordimeform use
      standard protective clothing as follows:  heavy-duty long-sleeve one
      piece worksuit, cloth cap, rubber or neoprene gloves, heavy-duty
      waterproof work boots (74).
           Skin contact with the product should be prevented through the use
      of nitrile gloves, neoprene raincoat, and neoprene boots (24b,c).

      PROTECTIVE EQUIPMENT:  Eye contact with the product should be avoided
      through the use of safety goggles.  This material should be handled in
      a well ventilated area.  Wear a Wilson R-21, Wilson R-15, or MSA EMP
      canister mask (24b,c).


                     IX.  PROCEDURES FOR SPILLS AND LEAKS

                    IN CASE OF EMERGENCY, CALL, DAY OR NIGHT
                                 (800) 424-9300
                     PESTICIDE TEAM SAFETY NETWORK/CHEMTREC

      Galecron 4E:

           Make sure all personnel involved in spill cleanup follow good
      industrial hygiene practices.
           Small spills can be handled routinely.  Wear nitrile gloves, mask,
      and neoprene suit and rubber gloves.  Cover the spill with an absorbent
      material such as vermiculite, lime, or sawdust.  Sweep up the material
      and place in an appropriate chemical waste container.  Seal container
      and dispose of in an approved landfill.  Wash the spill area with a
      saturated solution of sodium carbonate and a strong detergent.  Flush
      the spill area with water to remove any residue.  Do not allow to
      contaminate water supplies.
           Do not reuse container.  Destroy by perforation or crushing and
      burying in a safe place.
           Disposal of material, spill residues, wash water and containers
      must be by methods consistent with local, state and federal health and
      environmental regulations (24c).

      Galecron SP:

           Make sure all personnel involved in spill cleanup follow good
      industrial hygiene practices.
           Wear nitrile gloves, respirator, neoprene suit and neoprene boots.
      Evacuate all personnel.  Wearing protective equipment, contain spill.
      Keep dust down.  May need to lightly mist spill prior to clean-up.
      Tack rag, slightly damp cloth, or absorbent can be used.  Sweep up the
      material and place in an appropriate chemical waste container.  Wash
      the spill area with a strong detergent and water.  Sponge or mop up all
      liquid and place in a chemical waste container and seal for disposal.
      Flush the spill area with water to remove any residue.  Do not allow it
      to contaminate water supplies.
           All clean-up material, gloves, sponges, etc. that are contaminated
      should be disposed of in the waste container.  All personnel should
      wash thoroughly after clean-up operation is completed.
           Dust may be harmful or fatal if swallowed or absorbed through skin.
      Do not get in eyes, or skin or on clothing.  Avoid breathing dust.
           Disposal of material, spill residues, wash water and containers
      must be by methods consistent with local, state and federal health and
      environmental regulations (24b).


                               X.  LITERATURE CITED

       8a. Thomson, W. T.  1976.  Agricultural chemicals - book 1:
               insecticides, acaricides, and ovicides.  Revised ed.  Thomson
               Publ., Indianapolis, IN.  232 pp.

      24b. Ciba-Geigy Corporation, Agricultural Division.  1982.  Safety
               data sheet:  Galecron SP.  Greensboro, NC.

      24c. Ciba-Geigy Corporation, Agricultural Division.  1982. Safety data
               sheet:  Galecron 4E.  Greensboro, NC.

      25.  Morgan, D.P.  1982.  Recognition and management of pesticide
               poisonings, 3rd ed.  U.S. Environmental Protection Agency,
               Washington, DC.  120 pp.

      62.  The Pesticide Manual:  A World Compendium, 7th ed.  1983.  C.R.
               Worthing, ed.  The British Crop Protection Council, Croydon,
               England.  695 pp.

      74.  Farm Chemicals Handbook, 71st ed.  1985.  R.T. Meister, G.L. Berg,
               C. Sine, J. Poplyk, and G. Schilling, eds.  Meister Publishing
               Co., Willoughby, OH.

      5/1/85