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crufomate (Ruelene) Chemical Profile 4/85

                                  crufomate

      CHEMICAL NAME:      4-tert-Butyl-2-chlorophenyl methyl methyl-
                          phosphoramidate (56)

      TRADE NAME(S):      Ruelene (56)

      FORMULATION(S):     Emulsifiable concentrate, solution, or drench (6)

      TYPE:               Organophosphate livestock insecticide

      BASIC PRODUCER(S):  Dow Chemical U.S.A.
                          P.O. Box 1706
                          Midland, MI 48640

      STATUS:             General use.  Product discontinued by the Dow
                          Chemical Co.

      PRINCIPAL USES:  Mainly for control of cattle grubs, lice, and horn fly
      on cattle.  May be applied as a pour-on mixture or spray (6).


                                I.  EFFICACY

           To be developed.


                          II.  PHYSICAL PROPERTIES

      MOLECULAR FORMULA:   C12 H19 Cl NO3 P (26)

      MOLECULAR WEIGHT:    291.7 (26)

      PHYSICAL STATE:      Colorless crystals (pure compound); crystalline
                           (technical product) (26).

      MELTING POINT:       60 C (pure compound) (26)

      SOLUBILITY:          Practically insoluble in water (26)


                        III.  HEALTH HAZARD INFORMATION

      OSHA STANDARD:  None established

      NIOSH RECOMMENDED LIMIT:  None established

      ACGIH RECOMMENDED LIMIT:  None established

      TOXICOLOGY

           A.  ACUTE TOXICITY

               DERMAL:  LD50 = >2000 mg/kg (1)

               ORAL:    LD50 = 770-950 mg/kg (rat) (26)

           B.  SUBACUTE AND CHRONIC TOXICITY:

           To be developed.


                    IV.  ENVIRONMENTAL CONSIDERATIONS

           Slight hazard to birds, fish and beneficial insects.  Biological
      magnification unknown (1).

      Approximate Residual Period:  2-4 weeks on livestock (1).


                    V.  EMERGENCY AND FIRST AID PROCEDURES

           The chemical information provided below has been condensed
      from original source documents, primarily from "Recognition and
      Management of Pesticide Poisonings", 3rd ed. by Donald P.  Morgan,
      which have been footnoted.  This information has been provided in
      this form for your convenience and general guidance only.  In
      specific cases, further consultation and reference may be required
      and is recommended.  This information is not intended as a sub-
      stitute for a more exhaustive review of the literature nor for the
      judgement of a physician or other trained professional.

           If poisoning is suspected, do not wait for symptoms to develop.
      Contact a physician, the nearest hospital, or the nearest Poison
      Control Center.

      FREQUENT SYMPTOMS AND SIGNS OF POISONING BY ORGANOPHOSPHATE PESTICIDES

           Symptoms of acute poisoning develop during exposure or within 12
      hours (usually within four hours) of contact.  HEADACHE, DIZZINESS,
      WEAKNESS, INCOORDINATION, MUSCLE TWITCHING, TREMOR, NAUSEA, ABDOMINAL
      CRAMPS, DIARRHEA, and SWEATING are common early symptoms.  Blurred or
      dark vision, confusion, tightness in the chest, wheezing, productive
      cough, and PULMONARY EDEMA may occur.  Incontinence, unconsciousness
      and convulsions indicate very severe poisoning.  SLOW HEARTBEAT,
      salivation, and tearing are common.  TOXIC PSYCHOSIS, with manic or
      bizarre behavior, has led to misdiagnosis of acute alcoholism.  Slowing
      of the heartbeat may rarely progress to complete sinus arrest.
      RESPIRATORY DEPRESSION may be fatal.  Continuing daily absorption of
      organophosphate at intermediate dosage may cause an INFLUENZA-LIKE
      ILLNESS characterized by weakness, anorexia, and malaise (25).

           SKIN CONTACT:  Bathe and shampoo victim with soap and water if
      there is any chance that skin and hair are contaminated (25).

           INGESTION:  If victim is alert and respiration is not depressed,
      give Syrup of Ipecac, followed by 1-2 glasses of water to induce
      vomiting.  Adults (12 years and over): 30 ml; children: 15 ml (25).

      NOTES TO PHYSICIAN:

      Administer ATROPINE SULFATE intravenously, or intramuscularly, if IV
      injection is not possible.
      In MODERATELY SEVERE poisoning:  Adult dosage:  0.4-2.0 mg repeated
      every 15 minutes until atropinization is achieved:  tachycardia (pulse
      of 140 per minute), flushing, dry mouth, dilated pupils.  Maintain
      atropinization by repeated doses for 2-12 hours or longer depending on
      severity of poisoning.
      Dosage for children under 12 years:  0.05 mg/kg body weight, repeated
      every 15 minutes until atropinization is achieved.  Maintain
      atropinization with repeated dosage of 0.02-0.05 mg/kg.
      SEVERELY POISONED individuals may exhibit remarkable tolerance to
      atropine; two or more times the dosages suggested above may be needed.
      Administer PRALIDOXIME (Protopam (TM)-Ayerst, 2-PAM) in cases of severe
      poisoning in which respiratory depression, muscle weakness and
      twitchings are severe.
      Adult dosage:  1.0 gm intravenously at no more than 0.5 gm per minute.
      Child's dose (under 12 years):  20-50 mg/kg (depending on severity of
      poisoning) intravenously, injecting no more than half the total dose
      per minute.
      Dosage of pralidoxime may be repeated in 1-2 hours, then at 10-12 hour
      intervals if needed.  In very severe poisoning, dosage rates may be
      doubled (25).


                     VI.  FIRE AND EXPLOSION INFORMATION

           To be developed.


                            VII.  COMPATIBILITY

           Ordinarily not mixed with other materials (1).


                          VIII.  PROTECTIVE MEASURES

           To be developed.


                    IX.  PROCEDURES FOR SPILLS AND LEAKS

                   IN CASE OF EMERGENCY, CALL, DAY OR NIGHT
                                (800) 424-9300
                    PESTICIDE TEAM SAFETY NETWORK/CHEMTREC


                               X.  LITERATURE CITED

       1.  Harding, W.C.  1979.  Pesticide profiles, part one: insecticides
               and miticides.  Univ. Maryland, Coop. Ext. Serv. Bull. 267.
               30 pp.

       6.  Farm Chemicals Handbook, 66th ed.  1980.  G. L. Berg, C. Sine,
               S. Meister, and H. Shephard, eds.  Meister Publ. Co.,
               Willoughby, OH.

      25.  Morgan, D.P.  1982.  Recognition and management of
               pesticide poisonings, 3rd ed.  U. S. Environmental Protection
               Agency, Washington, DC.  120 pp.

      26.  The Pesticide Manual:  A World Compendium, 6th ed.  1979.  C. R.
               Worthing, ed.  The British Crop Protection Council, Croydon,
               England.  655 pp.

      56.  Farm Chemicals Handbook, 70th ed.  1984.  R. T. Meister, G. L.
               Berg, C. Sine, S. Meister, and J. Poplyk, eds.  Meister
               Publishing Co., Willoughby, OH.

      4/24/85