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cyfluthrin (Baythroid) Chemical Fact Sheet 12/87

                          CHEMICAL FACT SHEET FOR

FACT SHEET NUMBER: 164             

DATE ISSUED: DECEMBER 30, 1987                                              

1.  Description of Chemical                                                 
   - Generic Name:     Cyfluthrin (Cyano (4-fluoro-e-phenoxyphenyl) methyl  
   - Common Name:      Cyfluthrin                                           
   - Trade Name:       Laser                                                
   - EPA Shaughnessy Code:  128831, 128832, 128833, 128834, 128835          
   - Chemical Abstracts Service (CAS) Numbers:  68359-37-5                  
   - Year of Initial Registration:  1987                                    
   - Pesticide Type:   Insecticide                                          
   - Chemical Family:  Synthetic pyrethroids                                
   - U.S. Producers:   Mobay Chemical Company; Miles Laboratories, Inc.     
2.  Use Patterns and Formulations                                           
   - Application Sites:  General indoor and domestic outdoor (ornamental    
   - Method of Application:  Localized spot treatment, crack and crevice    
                             and space sprays.                              
   - Formulation Types:  a)  Laser Ant and Roach Killer                     
                             0.1% Cyfluthrin                                
                             1.0% Piperonyl Butoxide                        
                             0.05% Pyrethrins                               
                         b)  Laser Flying Insect Killer                     
                             0.04% Cyfluthrin                               
                             0.72% Tetramethrin                             
                             1.00% Piperonyl Butoxide                       
                         c)  Laser Flea Killer Spray                        
                             0.01% Cyfluthrin                               
                             0.8% Chlorpyrifos                              
                             2.5% Pyrethrins                                
                             1.0% Piperonyl Butoxide                        
                         d)  Laser Ant and Roach Killer II                  
                             0.10% Cyfluthrin                               
                             1.00% Propoxur                                 
                             0.25% Pyrethrins                               
                             1.00% Piperonyl Butoxide                       
                         e)  Laser House and Garden Multipurpose            
                             Insect Killer                                  
                             0.04% Cyfluthrin                               
                             0.35% Tetramethrin                             
                             1.00% Piperonyl Butoxide                       
   - Application Rates:  0.04 and 0.1% sprays                               
   - Usual Carriers:  Organic solvents; water                               
   - Limitations:  For Domestic Indoor and Outdoor Use Only                 
3.  Science Findings                                                        
   Chemical/Physical Characteristics of the Technical Material              
   - Physical State:  liquid                                                
   - Color:  dark amber                                                     
   - Odor:  aromatic solvent odor at room temperature                       
   - Melting Point:  not applicable                                         
   - Vapor Pressure:  2.1 x 10-8 mbars                                      
   - Density:  0.830 + 0.005 g/ml                                           
   - Solubility:  0.002 mg/ml at 20 C in water                              
   - Octanol/Water Partition Coefficient:  4.2 x 10^4                       
   Toxicological Characteristics                                            
   - Technical Cyfluthrin                                                   
     - Acute Oral (Mouse):                                                  
       - 83.6%     males:    291 mg/kg Toxicity Category II                 
                   females:  609 mg/kg                                      
     - Acute Dermal:  LD50 > 5000 mg/kg  Toxicity Category III              
     - 21-day Dermal (rat):  LD50 > 5000 mg/kg  Toxicity Category III       
     - Primary Dermal Irritation (rabbit):  None observed  Toxicity         
       Category IV                                                          
     - Skin Sensitization (guinea pig):  Not a sensitizer                   
     - Acute Inhalation:  LC50 (4 hour)    males - >0.735 mg/l              
                                           females - 0.200 - 0.735 mg/l     
     - Teratology:  (rat)  Maternal NOEL = 3 mg/kg/day                      
                           Maternal LEL = 10 mg/kg/day                      
                           Fetotoxic NOEL = 30 mg/kg/day                    
                           Teratogenic NOEL = 30 mg/kg/day                  
     - 2-Year Feeding/Oncogenicity:  (rat) Oncogenic NOEL = 22.5 mg/kg/day  
                                           Systemic NOEL = 2.5 mg/kg/day    
                                           Systemic NOEL = 7.5 mg/kg/day    
     - Gene Mutation:  negative                                             
     - Structural Chromosome Aberration:  negative                          
     - Unscheduled DNA Synthethesis:  negative                              
   - Laser Formulations                                                     
     - Acute Oral Toxicity in Rats: LD50 = >5000 mg/kg  Toxicity Category   
     - Acute Dermal Toxicity in rats:  LD50 = >2000 mg/kg  Toxicity         
       Category III                                                         
     - Acute Inhalation:  LC50 = >5 mg/l  Toxicity Category IV              
     - Primary Eye Irritation:  Toxicity Category IV                        
     - Primary Dermal Irritation:  PIS = 0.9  Toxicity Category IV          
     - Dermal Sensitization:  Not a sensitizer                              
Physiological and Biological Characteristics                                
   - The mode of action in biological systems is stomach and contact        
     exhibiting neuropathological characteristics typical of pyrethroid     
     insecticides.  Slight repellant effect.                                
   - Foliar absorption:  N/A                                                
   - Translocation:  N/A                                                    
   Environmental Characteristics                                            
   - Adequate data are sufficient to define the fate of cyfluthrin in the   
     environment.  Cyfluthrin is stable to hydrolysis at environmental pH   
     and temperature and to photolysis.  It photodegrades rapidly in a      
     half-life of <2 days at pH 9.  The major degradate is 4-fluoro-3-      
     phenxyl-benzaldehyde.  Under the conditions of the soil TD test using  
     various soils, (aged and unaged) cyfluthrin residues are considered    
     immobile in soils with a half-life of 56 to 63 days in German loam and 
     sandy loam, respectively.  Anaerobic conditions did not alter either   
     degradation rate or products.  Cyfluthrin's solubility in water is     
     determined to be 2 ppb (20 C).  It has a bioaccumulation factor in     
     fish of 858X.  Residues are depurated rapidly in untreated water.      
     Accumulated residues are found in non-edible tissue.  Cyfluthrin and   
     its degradates do not leach into the soil.  There are no concerns at   
     this time in regard to ground water.                                   
   Ecological Characteristics                                               
   - Avian Acute Oral:  Bobwhite quail - LD50 > 2000 mg/kg                  
   - Avian Subacute Dietary:  Mallard duck - LC50 > 5000 ppm                
                            Bobwhite quail - LC50 > 5000 ppm                
   - Freshwater Fish:  Bluegill - LC50 = 1.5 ppb                            
                  Rainbow Trout - LC50 = 0.68 ppb                           
   - Freshwater Invertebrate:  Daphnia magna LC50 = 0.14 pptr               
   - Marine/Estuarine Invertebrate:  Mysid shrimp - LC50 = 2.42 pptr        
                                   Eastern Oyster - LC50 = 3.2 pptr         
   - Marine/Estuarine Fish:  Sheepshead minnow - LC50 = 4.05 ppb            
   Summary Science Statement                                                
   - Technical cyfluthrin does not exhibit high mammalian toxicity.  It is  
     not considered to be mutagenic or teratogenic and is not a skin        
     sensitizer.  The results of the acute toxicity on the domestic use     
     formulations indicates that the chemical is of low toxicity.           
     Cyfluthrin has been tested in several studies (rat, mouse, chicken,    
     dog) for possible delayed type neurotoxicity and has been shown to be  
     neurotoxic when administered at relatively high dosage levels under    
     certain conditions.  However the neurotoxic dose levels were           
     considerably higher than those which elicited other signs of toxicity  
     indicating that cyfluthrin should not exhibit delayed type             
     neurotoxicity under conditions of use.  Chronic feeding and oncogenic  
     studies indicate that cyfluthrin is not an oncogen.                    
   - Sufficient data are available to characterize cyfluthrin from an       
     environmental fate and ecological effects standpoint.  Cyfluthrin is   
     extremely toxic to fish and aquatic organisms but is practically non-  
     toxic to upland game birds and waterfowl.  An acute contact LD50 study 
     indicated that cyfluthrin is toxic to the honey bee with an LD50 =     
     0.037 mg/bee.  Cyfluthrin undergoes rapid photolysis, is readily       
     degraded by soil and is relatively insoluble in water.  There is       
     little or no potential for leaching.                                   
   - A tolerance assessment is not needed because the registered use        
     pattern is for non-crop/non-food use.  There are no data gaps.         
4.  Summary of Regulatory Position and Rationale                            
   - The Agency has determined that it should allow the registration of     
     cyfluthrin for domestic indoor and outdoor use for control of          
     household pests, such as fleas, cockroaches, garden insects.  Adequate 
     data are available to assess the acute toxicological effects of        
     cyfluthrin to humans.  Since no crop, food or feed uses are proposed,  
     a tolerance assessment is not necessary.  As is typical of synthetic   
     pyrethroids, technical cyfluthrin is highly toxic to aquatic organisms 
     (invertebrates and fish).  However, the proposed use patterns should   
     not pose any environmental hazard.  None of the criteria for           
     unreasonable adverse effects listed in section 162.11(a) of Title 40   
     of the U.S. Code of Federal Regulations have been met or exceeded for  
     this use.                                                              
5.  Summary of Major Data Gaps                                              
   - There are no data gaps for the domestic indoor/outdoor use.            
6.  Contact Person at EPA                                                   
   George T. LaRocca                                                        
   Product Manager 15                                                       
   Insecticide-Rodenticide Branch                                           
   Registration Division (TS-767C)                                          
   Office of Pesticide Programs                                             
   Environmental Protection Agency                                          
   401 M Street, S.W.                                                       
   Washington, DC 20460                                                     
   - Office location and telephone number:                                  
     - Room 211, Crystal Mall #2                                            
     - 1921 Jefferson Davis Highway                                         
     - Arlington, VA 22202                                                  
     - (703) 557-2400