cyromazine (Larvadex,Trigard) Chemical Fact Sheet 12/86
Fact Sheet
Name of Chemical: Cyromazine
Reason for Issuance: New Chemical
Date Issued: December 1986
Fact Sheet Number: 105
1. DESCRIPTION OF CHEMICAL
Generic Name: N-cyclopropyl-1,3,5-triazine-2,4,6 triamine
Common Name: Cyromazine
Trade Name: Larvadex Technical and Premix (poultry feed through)
Trigard (celery and lettuce)
EPA Shaughnessy Code: #121301
Chemical Abstracts Service (CAS) Number: 66215-27-8
Year of Initial Registration: 1984
Pesticide Type: Insect Growth Regulator
Chemical Family: Triazine
Producer (U.S.only): Ciba-Geigy Corporation
2. USE PATTERN AND FORMULATION
A. Application Site: Feed through for poultry - caged layers only.
The active ingredient is passed through the chicken, leaving a
residue in the manure that controls the growth of the fly larvae
developing there.
Type of Formulation: Premix - a coarsely ground powder
Application Rates: Mix 1 lb of Larvadex (0.3% Premix) per ton of
feed for control of housefly and soldier fly; for lesser.housefly,
mix 3.33 lbs of Larvadex (0.3% Premix) per ton of feed.
B. Application sites- Celery and lettuce
Type of Formulation, Wettable Powder - this product is only packaged
in 2 lb. water soluble bags
Application Rates - One 2 lb. package mixed in the appropriate
amount of water will treat 12 acres - this is 1/6 lb. Trigard 75W per
acre.
3. SCIENCE FINDINGS
Based on calculations and environmental chemistry data, there is no
expectation for unreasonable adverse effects to nontarget organisms from
the proposed uses of cyromazine. Sufficient data are available to
support conditional registration of cyromazine as an insect growth
regulator in and around poultry houses and for use on celery and
lettuce.
Chemical Characteristics of the Technical Chemical
Physical state: crystalline solid
Color: white
Odor: odorless
Boiling point: Not applicable
Melting point: 220 degrees to 222 degrees C
Flammability: Not applicable
Solubility in water: 1.1%
There are no unusual handling characteristics.
Toxicology Characteristics
- Acute oral LD (rat); LD = 3387-mg/kg
Toxicology Category III
- Acute oral LD (mouse); LD = 2029 mg/kg
Toxicology Category III
- Acute oral LD (rabbit); LD = 1467 mg/ kg
Toxicology Category III
- Acute dermal LD (rat); LD >3100 mg/kg
Toxicity Category III
- Primary- dermal irritation (rabbit); PIS = 1.1/8 0
Toxicology Category IV
- Primary eye irritation (rabbit); Negative
Toxicology Category IV
- Skin sensitization (guinea pig): nonsensitizing
Toxicology Category: N/A
- Mutagenic (Salmonella): Negative for point mutations in TA1535,
TA1537, TA98, TA100 with and without activation
- 90-Day feeding (dog): NOEL = 300 ppm: LEL = 1000 ppm;
levels tested = 0, 30, 300, and 3000 ppm.
- 6 months feeding (dog); NOEL = 30 ppm; LEL = 300 ppm;
levels tested = 30, 300 and 300 ppm.
- Teratology (rat); Negative for teratogenic effects up to and including
1000 my/kg/day.
- Teratology (rabbit); NOEL for teratogenic effects at 5 mg/kg/day:
Maternal NOEL at 10 mg/kg/day.
- 2-Generation reproduction: Systemic NOEL = 30 ppm;
systemic LEL = 1000 ppm; levels tested = 0, 30, 100 and 3000 ppm.
- 2-Year feeding/Oncogenicity (rat); NOEL = 30 ppm:
LEL = 300 ppm; negative for oncogenic.effects at 3000 ppm (HDT)
- Mutagenic (dominant and nucleus): negative
Physiological and Biochemical Behavioral Characteristics
- Mechanism of pesticidal action: Cyromazine is not a cholinesterase
inhibitor. As an insect growth regulator, cyrozine exerts its toxic
action by affecting the nervous system of the immature stages (larvae)
of certain insects.
Environmental Characteristics
- Cyromazine is practically nontoxic (acutely) to mammals and birds.
Exposure estimates for these organisms are <0.05 ppm. Acute toxicity
for birds is 1785 ppm maximum. Safety factor is 105-106 for birds.
Acute toxicity for mammals is 1000 ppm maximum. Safety factor is
again 105 - 106. A summary of the environmental chemistry factors
to be considered in this hazard assessment indicates that:
- Cyromazine is stable to hydrolysis; photolysis is the
dominant physico-chemical degradation mechanism.
- Cyromazine is not expected to build up in soils; at 5 ppm in
chicken manure (5 tons/A) <0.05 ppm cyromazine is expected in
soils. Half lives in soil-manure are 1 year (lab) and 12 weeks
(field/greenhouse).
- Cyromazine is not expected to build up in plants or crops; <0.05 ppm
is expected from typical chicken manure applications.
- Cyromazine is not expected to build up in animal tissues; fish
bioconcentration factors are expected to be between 0.2-7.8X.
- Cyromazine has no detrimental effects on soil microorganisms.
- Cyromazine has a low to moderate mobility in sandy or loam sand
soils.
Ecological Characteristics:
Avian Acute Oral LD50
Species LD50
Mallard duck >2510 mg/kg
Bobwhite quail 1785 (1444-2206) mg/kg
Peking duck >6000 mg/kg
Avian.- Dietary LC50
Species LD50
Mallard duck. >5620 ppm
Bobwhite quail >5620 ppm
Fish Acute LC50 (96-hr)
Species 96 hr LC50
Bluegill sunfish >89.7 mg/l
Rainbow trout >87.9 mg/l
Channel catfish >92.4 mg/l
Aquatic Invertebrate LC50
Species 48 hr LC50
Daphnia magna >97.8 mg/l
Summary of Tolerances 40 CFR S180.414
Commodities Parts Per Million
Eggs .............................................0.25
Meat of Poultry ..................................0.05
Fat of Poultry ...................................0.05
Meat by-products of Poultry ......................0.05
Poultry feed (see 21 CF)...........................5.0
Celery ..........................................10.0
Lettuce ......................................... 5.0
SUMMARY OF REGULATORY POSITION
Use classification.: N/A
Use, formulation or geographical restrictions: Larvadex has been
approved for use in poultry feed for caged layers as a feed through
pesticide to control flies in the manure. Trigard has been approved for
use on celery and lettuce as a conventional spray on emulsion to control
leafminers. Products containing cyromazine are to be stored in cool, dry
places. There are no geographical restrictions or unique warning
statements required on the label.
5. SUMMARY OF MAJOR DATA GAPS
- Toxicology: None
- Environmental Fate: Applicator Exposure Study
- Environmental Safety: None
- Residue Chemistry: None
6. CONTACT PERSON AT EPA
Arturo E. Castillo, PM-17
Insecticide-Rodenticide Branch (TS-767)
401 M Street SW.
Washington, DC 20460
(703) 557-4414
DISCLAIMER: The information presented in this Chemical Information Fact
Sheet is for informational purposes only and may not be used to fulfill
data requirements for pesticide registration and reregistration.
Disclaimer: Please read
the pesticide label prior to use. The information contained at this web
site is not a substitute for a pesticide label. Trade names used herein
are for convenience only; no endorsement of products is intended, nor is
criticism of unnamed products implied. Most of this information is historical
in nature and may no longer be applicable.
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