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fenoxycarb (Ro 13-5223) Chemical Fact Sheet 2/86

                           CHEMICAL FACT SHEET FOR:
                                 FENOXYCARB

   FACT SHEET NUMBER: 78

   DATE ISSUED: FEBRUARY , 1986


                      1.  DESCRIPTION OF CHEMICAL

- Generic Name:  ethyl[2-(4-phenoxyphenoxy)ethyl]carbamate
- Common Name:  fenoxycarb
- Trade Names:  Logic, Ro 13-5223
- EPA Shaughnessy Code:  128801
- Chemical Abstracts Service (CAS) Number:  72490-01-8
- Year of Initial Registration:  1985
- Pesticide Type:  Insecticide/Miticide
- Chemical Family:  carbamate
- U,S. and Foreign Producers:  MAAG Agrochemicals


                 2.  USE PATTERNS AND FORMULATIONS

  Fenoxycarb is registered for use as a bait to control fire ants in or
  on turf, lawns, and non-agricultural land such as airport turfs,
  parks, and golf courses.  Applications are made as single mounds (1 to
  3 level tablespoons per mound) and broadcasting (apply uniformly with
  ground equipment calibrated to give correct dosage (1 to 1.5 lb/A)).


                    3.  SCIENCE FINDINGS

Chemical Characteristics

  Technical fenoxycarb is a light brown lumpy powder, stable under
  normal conditions. Slight hydrolysis occurs in aqueous solution at
  pH 3, 7, and 9 at 35 degrees C and 50 degrees C for a period of time
  up to 70 days.  It is very soluble (250 g/l solvent) in most organic
  solvents (e.g., acetone, chloroform, diethyl ether, diethyl formamide,
  ethyl acetate, methanol, toluene).  It is slightly soluble in hexane
  (5 g/l solvent).


Toxicological Characteristics

- Fenoxycarb is moderately toxic (Tox Category III from acute oral
  and dermal routes of exposure).
- Toxicology studies on fenoxycarb are as follows:
  - Oral LD50 in rats:  LD50 > 16,800 mg/kg
  - Dermal LD50 in rats:  LD50 > 5,000 mg/kg; effects included
    dyspnea, curved body position, ruffled fur, sedation, and
    diarrhea.  No deaths occurred.
  - Metabolism study in rats:  90-92% excreted in 96 hours.  Organs
    did not show persistent residues.
  - Rat 52-week interim report:  NOEL = 200 ppm.
  - Teratogenicity:  Teratogenic effects were not observed at dose
    levels up to 300 mg/kg/day, which was the highest dose tested.
  - Mutagenicity:  Nonmutagenic
  - Dermal sensitization:  Not sensitizing
  - 21-day dermal:  NOEL = 200 mg/kg/day (slight erythema; elevated
    liver weight at top dose).


Physiological and Biochemical Characteristics

  Fenoxycarb is an Insecticide that disrupts the development of the
  pest.  Fenoxycarb has an insect-specific mode of action exhibiting
  strong juvenile hormone activity.  It inhibits metamorphosis to
  the adult stage, induces interference with the molting of early
  instar larvae, and produces certain ovicide and delayed larvicide/
  adulticide effects in various insect species.


Environmental Characteristics

- Fenoxycarb is stable to hydrolysis at pH 3-9 and temperatures
  up to 50 degrees C.  However, fenoxycarb is expected to photodegrade
  in pure and natural water with a half-life of five hours.
- Field studies indicate that under exaggerated and normal use
  conditions, dissipation of fenoxycarb in soil is rapid; residues
  are no longer detectable three days after application.
- Soil column studies using fresh and aged soils indicate a low
  potential for leaching.  Adsorption/desorption studies indicate
  moderate to strong soil binding.  Fish exposed to fenoxycarb in
  water will bioaccumulate fenoxycarb to concentrations 300X greater
  than the concentration in the water.  However, the fish will
  release 99% of the residues within 2 weeks when placed in water
  containing no fenoxycarb.


Ecological Characteristics

- Avian oral LD50 = > 3,000 mg/kg (mallard ducks).
- Avian dietary LC50 = 11,574 ppm (bobwhite quail).  Data show that
  fenoxycarb is practically nontoxic to birds.
- Fish LC50 = 1.6 ppm for rainbow trout and 1.86 ppm for bluegill.
  Data show that fenoxycarb is moderately toxic to fish,
- Data submitted indicate that fenoxycarb is low to moderate in
  toxicity to honeybees.  Bee hazard is decreased because the
  pesticide will be formulated as a grit or corncob bait, which
  will result in little or no bee exposure.  Thus, currently
  registered uses of the formulated product should present no hazard
  to bees.
- It is unlikely that the use of fenoxycarb would adversely affect
  endangered aquatic species, because of the low acute toxicity of
  fenoxycarb to this group and the low use rates.  The expected
  concentrations in 6 inches of water are less than 1/20 the fish
  LC50 and 1/20 the Daphnia LC50.
- It is unlikely that the use of fenoxycarb would affect avian
  species, because of its low acute toxicity and low use rate.
  levels up to 300 mg/kg/day, which was the highest dose tested.
  - Mutagenicity:  Nonmutagenic
  - Dermal sensitization:  Not sensitizing
  - 21-day dermal:  NOEL = 200 mg/kg/day (slight erythema; elevated
  liver weight at top dose).


Physiological and Biochemical Characteristics

  Fenoxycarb is an insecticide that disrupts the development of the
  pest.  Fenoxycarb has an insect-specific mode of action exhibiting
  strong juvenile hormone activity.  It inhibits metamorphosis to
  the adult stage, induces interference with the molting of early
  instar larvae, and produces certain ovicide and delayed larvicide/
  adulticide effects in various insect species.


Environmental Characteristics

- Fenoxycarb is stable to hydrolysis at pH 3-9 and temperatures
  up to 50 degrees C.  However, fenoxycarb is expected to photodegrade
  in pure and natural water with a half-life of five hours.
- Field studies indicate that under exaggerated and normal use
  conditions, dissipation of fenoxycarb in soil is rapid; residues
  are no longer detectable three days after application.
- Soil column studies using fresh and aged soils indicate a low
  potential for leaching.  Adsorption/desorption studies indicate
  moderate to strong soil binding.  Fish exposed to fenoxycarb in
  water will bioaccumulate fenoxycarb to concentrations 300X greater
  than the concentration in the water.  However, the fish will
  release 99% of the residues within 2 weeks when placed in water
  containing no fenoxycarb.


Ecological Characteristics

- Avian oral LD50 = > 3,000 mg/kg (mallard ducks).
- Avian dietary LC50 = 11,574 ppm (bobwhite quail).  Data show that
  fenoxycarb is practically nontoxic to birds.
- Fish LC50 = 1.6 ppm for rainbow trout and 1.86 ppm for bluegill.
  Data show that fenoxycarb is moderately toxic to fish.
- Data submitted indicate that fenoxycarb is low to moderate in
  toxicity to honeybees.  Bee hazard is decreased because the
  pesticide will be formulated as a grit or corncob bait, which
  will result in little or no bee exposure.  Thus, currently
  registered uses of the formulated product should present no hazard
  to bees.
- It is unlikely that the use of fenoxycarb would adversely affect
  endangered aquatic species, because of the low acute toxicity of
  fenoxycarb to this group and the low use rates.  The expected
  concentrations in 6 inches of water are less than 1/20 the fish
  LC50 and 1/20 the Daphnia LC50.
- It is unlikely that the use of fenoxycarb would affect avian
  species, because of its low acute toxicity and low use rate.


                  5. SUMMARY OF MAJOR DATA GAPS

Environmental fate:  Soil photolysis, due date 2/86.


                   6.  CONTACT PERSON AT EPA

Timothy A. Gardner
Product Manager 17
Insecticide-Rodenticide Branch (TS-767C)
401 M Street S.W.
Washington, DC  20460
(703) 557-2690


DISCLAIMER:  THE INFORMATION PRESENTED IN THIS CHEMICAL INFORMATION FACT 
SHEET IS FOR INFORMATIONAL PURPOSES ONLY AND NOT TO BE USED TO FULFILL 
DATA REQUIREMENTS FOR PESTICIDE REGISTRATION AND REREGISTRATION.