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Fenpropathrin - Chemical Fact Sheet 12/89

Name of Chemical:  Fenpropathrin
Reason for Issuance:  New Chemical
Date Issued:  December 22, 1989
Fact Sheet Number:   210

                     1.  DESCRIPTION OF THE CHEMICAL

Generic Name:  (alpha-Cyano-3-phenoxybenzyl-2,2,3,3-tetramethyl
Common Name:  Fenpropathrin (proposed)
Trade Name:  Danitol
Other Names:  S-3206, ML-41706, SD-41706
EPA Shaughnessy Code (OPP Chemical Code):  127901
Chemical Abstracts Service (CAS) Number:  39515-41-8
Year of Initial Registration:  1989
Pesticide Type:  Insecticide-Miticide
Chemical Family:  Pyrethroid
Producer:  Sumitomo Chemical Company, Ltd.

                     2.  USE PATTERNS AND FORMULATIONS

- Application Sites:  Greenhouse Ornamentals including Lath House and
  Shade House Use (container-grown plants only).
- Type and Methods of Application:  Foliar spray (ground application)
- Rates of Application:  0.1 to 0.3 pound active ingredient (ai) per
  100 gallons of spray (5.33 to 16 oz product).
- Types of Formulations:  90% Technical; 2.4 Emulsifiable Concentrate
  Spray (30% ai; 2.4 lb ai/gallon).
- Usual Carriers:  Water.
- Target Pests:  Mites (two spotted, Southern Red, European Red,
  McDaniel), Aphids (apple, wooly apple, rose), Beet armyworm, mealybug
  (including immature stages of citrus mealybug), potato leafhopper, San
  Jose scale (crawlers, Japanese Beetle, spotted tentiform leafminer,
  thrips, Pandemis moth, codling moth, leafrollers, southern red pine,
- Limitations:  For Commercial Greenhouse Use Only.

                           3.  SCIENCE FINDINGS

Summary Science Statement

   The end-use product (Danitol 2.4 EC Spray) has moderate to low acute
oral, dermal, inhalation and eye/skin irritation toxicity.  This product
is assigned to Toxicity Category II (Warning) due to oral route of
exposure and eye irritation hazard.  The technical product is highly
toxic to mammals by the oral route, with rat oral LD50 values o# 54.0
mg/kg (male), and 48.5 mg/kg (female).  There was no evidence of any
carcinogenic effects in a 2-year dietary study (0, 40, 150, 600 ppm) in
rats at dose levels up to and including 600 ppm.  No developmental toxic
effects were observed in rats at dose levels greater than 10 mg/kg/ day
nor in rabbits at levels greater than 36 mg/kg/day (highest dose levels
tested).  Fenpropathrin was not found to be mutagenic. Laboratory data
indicate fenpropathrin is extremely toxic to fish and aquatic organisms
and is toxic to wildlife.  Leaching data show that fenpropathrin and its
aged residues are unlikely to leach in most soils.  It is unlikely that
ground water contamination will occur.

Chemical Characteristics:  (Technical Grade)

- Physical State:  Liquid or solid
- Color:  Yellowish brown
- Odor:  Faint characteristic odor
- Melting Point:  25-50 degrees C
- Boiling Point:  377 degrees C
- Specific Gravity:  d 20/20 = 1.05
- Density at 20 degrees C:  1.103
- Empirical Formula:  C24H2503N
- Molecular Weight:  349.4
- Solubility:  0.33  ppm at 25 degrees C in H2O; easily soluble in
  common organic solvents
- Octanol/Water Partition Coefficient:  Pow = 1 x 10 minus 6
- Storage Stability:  Data indicate that S-3206 is stable in organic
  solvents at warehouse temperature and in light of wavelengths above
  350 nm.

Toxicology Characteristics

Technical Formulation:

- Acute Oral Toxicity, Rat:  LD50 = 54.0 mg/kg (males ), 48.5
  mg/kg (females).  Toxicity Category I
- Acute Dermal, Rat:  LD50 = 1600 mg/kg (males), 870 mg/kg
  (females).  Toxicity Category II.
- Acute Inhalation LC50, Mouse and Rat:  The maximum attainable
  concentration (0.009 ug/L as vapor) was nontoxic.  Toxicity
  Category IV.
- Primary Eye Irritation, Rabbit:  No corneal involvement.  Mild iris
  and conjunctival irritant.  Toxicity Category III.
- Primary Dermal Irritation, Rabbit:  Not an irritant.  Toxicity
  Category IV.
- Dermal Sensitization, Guinea Pig:  Not a sensitizer.
- Neurotoxicity, Hen:  No delayed neurotoxicity at < 1000 mg/kg/day x 5.
- 2-Year Feeding/Carcinogenic, Mouse:  Systemic NOEL > 600 ppm (HDT; M/F
  56.0/65.2 mg/kg/day).  There were no indications of toxicity or
  oncogenicity other than marginally increased hyperactivity in females
  dosed at 600 ppm.
- 2-Year Feeding/Carcinogenic, Rat:  Systemic NOEL = 450 ppm (17.06
  mg/kg/day) in males, 150 ppm (7.23 mg/kg/day) in females Systemic
  LEL = 600 ppm (HDT; 22.80 mg/kg/day) in males (increased mortality,
  body tremors, increased pituitary, kidney, and adrenal weights) 450
  ppm (19.45 mg/kg/day) in females (increased mortality and body
- There was no evidence of oncogenicity at any dose.
- 1-Year Feeding, Dog:  Systemic NOEL = 2.5 mg/kg/day
                        Systemic LEL = 6.25 mg/kg/day
- Developmental Toxicity, Rabbit:
  - Maternal NOEL = 4 mg/kg/day
  - Maternal LEL = 12 mg/kg/day (grooming, anorexia, flicking of the
  - Developmental NOEL > 36 mg/kg/day (HDT)
- Developmental Toxicity, Rat:
  - Maternal NOEL = 0.4 mg/kg/day
  - Maternal LEL = 2.0 mg/kg/day
  - Developmental NOEL > 10 mg/kg/day (HDT)

- 3-Generation Reproduction, Rat:
  - Parents:  Systemic NOEL = 40 ppm (M/F 3.0/3.4 mg/kg/day)
              Systemic NOEL = 120 ppm (M/F 8.9/10.1 mg/kg/day) (body
                tremors with spasmodic muscle twitches, increased
                sensitivity and maternal lethality)
  - Pups:  Reproductive NOEL = 120 ppm (M/F 8.0/10.1 mg/kg/day)
           Reproductive LEL = 360 ppm (M/F 26.9/32.0 mg/kg/day)
            (decreased mean F1B pup weight, increased F2B loss)
           Fetotoxic NOEL = 40 ppm (M/F 3.0/3.4 mg/kg/day)
           Fetotoxic LEL = 120 ppm (M/F 8.9/10.1 mg/kg/day) (body
             tremors, increased mortality)

Mutagenicity Studies

A. Gene Mutation Test:  Negative for Salmonella TA98, TA100, TA1535,
   TA1537, and TA1538; and E. coli WP2uvrA (trp ) with or without
   metabolic activation.

    In Vitro Assay in             Equivocal results - probably of no
    Mouse Lymphoma cells          concern

B. Structural Chromosome          Data submitted October 1989 and under
    Aberration Test:              review.

C.  In Vitro Sister Chromatid     There were no increases in sister
     Exchange Test:               chromatid exchanges seen in CHO-K1

D.  DNA Damaging Sister           Not mutagenic
     Chromatid Exchange Test

Metabolism Studies:

A.  Metabolism, Rat               97% is eliminated in 48 hours.
    (2 studies)                   Little residue after 8 days. Highest
                                  concentration in fat.  Metabolites
                                  were identified in urine.

B. Percutaneous Absorption,       Over a 24-hour period, very little
    Rat                           test article was absorbed through the
                                  skin.  The major route of elimination
                                  was the urine.

End-Use Formulation:

- Acute Oral, Rat:  LD50 = 72.4 mg/kg (males), 71.8 mg/kg
  (females) and 72.1 mg/kg (both sexes).  Toxicity Category II
- Acute Dermal, Rabbit:  LD50 > 2000 mg/kg.  Toxicity Category III
- Acute Inhalation, Rat:  LC50 = 3.72 mg/L (males, 2.75 mg/L
  (females), 3.20 mg/L (both sexes).  Toxicity Category III
- Primary Eye Irritation, Rabbit:   Moderately persistent corneal
  opacity.  Toxicity Category II
- Primary Dermal Irritation, Rabbit:  Draize Score = 2.2.  Toxicity
  Category III
- Skin Sensitization, Guinea Pig:  Not a sensitizer
- 21-Day Dermal, Rabbits:  Local irritation only at dose levels of 100
  mg/kg/day and above.  No systemic pathology at 900 mg/kg (HDT)

Physiological and Biochemical Characteristics

- Foliar Absorption:  Not absorbed
- Translocation: Not translocated
- Mechanism of Pesticide Action:  Neurotoxicity characteristic of

  pyrethroid insecticides (contact action).

Ecological Effects Characteristics

- Avian Acute Oral
  - Mallard Duck:  LD50 = 1089 mg/kg
- Avian Dietary
  - Bobwhite quail:  LD50 = > 10,000
  - Mallard duck:  LC50 = 9026 ppm
  - Freshwater Fish
  - Rainbow trout:  LC50 = 2.3 ppb
  - Bluegill:  LC50 = 2.2 ppb
  - Channel catfish:  LC50 = 5.5 ppb
  - Sheepshead minnow:  LC50 = 31 ppb
- Aquatic Invertebrate
  - Daphnia magna:  LC50 = 0.53 ppb (48 hr)
  - Daphnia magna:  MATC > 0.22 < 0.35 ppb
- Avian Reproduction Studies
  - Bobwhite quail:  Environmental concentrations of up to 2.0 ppm do
    not present a reproductive hazard
    - Mallard duck:  No reproductive related effects were seen at 2.0
      ppm (HDT).

Environmental Fate and Ground water Characteristics:

- Hydrolysis:  Stable at environmental pH (pH 6-8) and temperature of
  25 degrees C.
- Aerobic Soil Metabolism:  Degrades under aerobic soil conditions with
  a half-life of 33 to 34 days.  Fenpropathrin degrades to desphenyl-
  fenpropathrin and other minor metabolites which undergo further
  degradation to C02.
- Mobility/Leaching:  Soil column leaching data show that fenpropathrin
  and its aged residues are unlikely to leach in most soils.  However,
  some leaching may occur in sand soils very low in organic matter
  (e.g., 0.1% organic matter).
- Environmental Fate and Surface and Ground Water Contamination
  Concerns:  No concerns at this time.
- Exposure of Humans and Nontarget Organisms to Chemical or Degradates:
  Applicator exposure in greenhouse:  Fenpropathrin is not highly
  toxic by the dermal or inhalation route; however, the formulated
  product can be irritating to the eyes.  Goggles or a face shield
  will provide protection to the eyes in case of accidental splashing
  during mixing/loading and during spraying.
- Exposure During Reentry Operations:  No special precautions needed
  in greenhouses once spray residues are dry.

Tolerance Assessment

Not applicable for greenhouse ornamental crops.


   The Agency has determined that it should allow the unconditional
registration of fenpropathrin to control pests for greenhouse use since
all of the data required to support this use pattern have been sub-
mitted, reviewed and found acceptable.  Adequate data are available to
assess the acute and chronic effects of fenpropathrin to humans.  Based
on exposure to aquatic organisms and terrestrial wildlife from green-
house usage, adverse effects to nontarget organisms and endangered
species are unlikely.  Likewise, surface and groundwater contamination
is unlikely from greenhouse usage.

                           5.  SUMMARY OF DATA GAPS



The following use limitations must appear on products registered for
use in greenhouses:

- For commercial greenhouse use only.

  - Do not reenter treated areas until sprays have dried.

  - Do not apply this product through any type of irrigation

  - Appropriate personal protective equipment and work safety
    statements must appear on the label of products registered
    for use on/in lath house, shade house, and greenhouse.

                         7.  CONTACT PERSON AT EPA

George T. LaRocca
Product Manager 15
Insecticide-Rodenticide Branch
Registration Division (H7505C)
Office of Pesticide Programs
U.S. Environmental Protection Agency
401 M Street SW.
Washington, DC  20460

Office location and telephone number:

Rm. 203, CM #2
1921 Jefferson Davis Highway
Arlington, VA  22202

(703) 557-2400