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fenvalerate (Pydrin) Chemical Profile 3/85


      CHEMICAL NAME:  cyano(3-phenoxyphenyl)methyl 4-chloroalpha-
                      (1-methylethyl) benzeneacetate (56)

      TRADE NAME(S):  Pydrin, Ectrin (56)

      FORMULATION(S): Pydrin in 2.4 pounds a.i. per gallon emulsible
                      concentrate.  Presently packaged in 1-quart glass,
                      1-gallon plastic, and 5,30, and 55-gallon metal
                      containers.  Ectrin in 10 gram eartags and 10% liquid
                      formulation in 1 quart container (56).

      TYPE:           Synthetic pyrethroid insecticide

      BASIC PRODUCER(S):  Shell Chemical Company, A Division of Shell Oil
                          P. O. Box 3871
                          Houston, TX  77001

                          SDS Biotech Corp.
                          7528 Auburn Rd.
                          P.O. Box 348
                          Painesville, OH 44077

      STATUS:         Restricted use

      PRINCIPAL USES:  Insects on fruit, field crops, and vegetables.
      Nonsystemic (1).
           Pydrin was conditionally registered by EPA in early 1979 for use
      on cotton, and in late 1980 for use on peanuts, potatoes, and pears
      (dormant).  Tolerances have been established for cotton, peanuts,
      potatoes, pears, apples, peaches, pecans, filberts, cabbage, melons,
      pumpkins, winter squash, summer squash, tomatoes, cucumbers, field corn,
      sweet corn, dry beans, dry peas, broccoli, cauliflower, soybeans,
      artichokes, eggplant, peppers, fat of milk, and meat and meat byproducts.
           Ectrin used in dairy and beef cattle eartags for control of
      hornflies, faceflies, Gulf Coast ticks, spinose ear ticks, and as an aid
      to control stable flies and house flies (56).

                                I.  EFFICACY

      Important Pests Controlled:  Cotton bollworm, cotton leaf perforator,
      leafhoppers, thrips, tobacco budworm, lygus bugs, and many lepidopterous
      species (8a).
           Gives good residual control with a fast knockdown (8a).

                             II.  PHYSICAL PROPERTIES

      MOLECULAR FORMULA:  C25 H22 Cl NO3 (62)

      MOLECULAR WEIGHT:   419.9 (62)

      PHYSICAL STATE:     Viscous yellow or brown liquid, sometimes partly
                          crystallized at room temperature (technical grade)

      ODOR:               Mild chemical odor (56)

      VAPOR PRESSURE:     37 uPa at 25 C (technical grade) (62)

      SOLUBILITY:         < 1 mg /l water at 20 C (technical grade) (62)

                           III.  HEALTH HAZARD INFORMATION

      OSHA STANDARD:  None established

      NIOSH RECOMMENDED LIMIT:  None established

      ACGIH RECOMMENDED LIMIT:  None established - for xylene (solvent in
                                Pydrin): TWA (Time Weighted Average) = 435
                                mg/m3; STEL (Short Term Exposure Limit) =
                                655 mg/m 3 (18a).


           A.  ACUTE TOXICITY

               DERMAL:  LD50 = 2500 mg/kg (rabbit); >5000 mg/kg (rat) (56).
                        May be irritating to the skin (8a).

               ORAL:    LD50 = 451 mg/kg (DMSO, rat); >3200 mg/kg (aqueous
                          suspension, rat) (56).
                        LD50 = 451 mg/kg (rat), > 1600 mg/kg (domestic fowl)

               INHALATION:  Irritating to the nose and throat (18a)

               EYES:    Can cause eye irritation or damage (18a)
                        May be irritating to the eyes (8a).


           In 2-yr feeding trials NEL for rats was 250 mg/kg diet (62).


           Some hazard to fish, beneficial insects and honey bees.  Biological
      magnification unlikely.  Nonphytotoxic (1).  Pydrin is highly toxic to
      bees and extremely toxic to fish (18a).

      The LC50 (96 hr) for rainbow trout is 3.6 ug/l (62).

      Approximate Residual Period: 1-3 weeks on plants or exposed surfaces (1).


           The chemical information provided below has been condensed
      from original source documents, primarily from "Recognition and
      Management of Pesticide Poisonings", 3rd ed. by Donald P.  Morgan,
      which have been footnoted.  This information has been provided in
      this form for your convenience and general guidance only.  In
      specific cases, further consultation and reference may be required
      and is recommended.  This information is not intended as a sub-
      stitute for a more exhaustive review of the literature nor for the
      judgement of a physician or other trained professional.

           If poisoning is suspected, do not wait for symptoms to develop.
      Contact a physician, the nearest hospital, or the nearest Poison
      Control Center.


      A STUFFY, RUNNY NOSE and scratchy throat from inhalation of partly
      purified pyrethrum extract is the most common adverse effect of these
      agents.  Asthmatic WHEEZING may be precipitated by exposure of
      predisposed individuals.  Sudden bronchospasm, swelling of oral and
      laryngeal mucous membranes, and shock (anaphylaxis) have been reported
      after pyrethrum inhalation.  Delayed appearance of dyspnea, cough and
      fever, with patchy lung infiltrates on x-ray, suggest hypersensitivity
      pneumonitis.  Nervous irritability, tremors, and ataxis have occurred
      rarely in persons who have had massive inhalation exposure to
      pyrethrins.  Halocarbon propellents in bug-bomb products present a risk
      of CARDIAC ARRHYTHMIA and possibly fibrillation if inhaled to excess.
      Hydrocarbons used as solvents in spray products are likely to result in
      COUGH, FEVER, and CHEST PAIN (hydrocarbon pneumonitis) if these liquids
      are inadvertently aspirated (25).

           SKIN CONTACT:  Irritating to skin.  Wash thoroughly with soap and
      water.  If abnormal skin sensations occur (i.e., tingling, burning, or
      itching), immediately apply vegetable oil to affected areas.  Reapply
      every 30 minutes if symptoms recur and use until symptoms are gone.  Get
      medical attention if irritation is severe (18a).

           INGESTION:  No specific antidote is known.  In cases of ingestion
      carry out gastric lavage with care to prevent aspiration.  Treat
      symptomatically (56).

           EYE CONTACT:  Can cause eye irritation or damage.  Flush with plenty
      of water for 15 minutes.  Get medical attention (18a).


      If victim is not fully alert, empty stomach immediately by intubation,
      aspiration, and lavage, using isotonic saline or 5% sodium
      bicarbonate.  Because many pesticides are dissolved in petroleum
      distillates, emesis and intubation of the stomach involve a risk that
      solvent will be aspirated, leading to chemical pneumonitis.  Do not
      administer or instill milk, cream, or other substances containing
      vegetable or animal fats, which enhance absorption of lipophilic
      substances, such as pyrethrins and pyrethroids.

      Diazepam (Valium (TM)), 5-10 mg in adults, 0.1 mg/kg in children, given
      orally or slowly IV, should control nervousness and tremors in rare
      cases having these symptoms after extraordinary exposure to pyrethrins
      and pyrethroids (25).

                         VI.  FIRE AND EXPLOSION INFORMATION

           Technical Pyrdrin has a high flash point and is a relatively
      minor fire hazard.  However, Pydrin 2.4 EC will burn if exposed to an
      ignition source.  Do not use, pour, or store near heat or open flame.
      With sufficient heat, either product may decompose, releasing noxious
      fumes such as hydrogen cyanide, which could be fatal if inhaled.  Fire
      fighters should use a supplied air pressure - demand self-contained
      breathing apparatus for protection against both toxic and oxygen
      deficient atmospheres.  Respirators with canisters or cartridges should
      not be used (18a).

                                 VII.  COMPATIBILITY

           Generally compatible with most insecticides and fungicides (1).

                             VIII.  PROTECTIVE MEASURES

      STORAGE AND HANDLING:  Store in a locked cool place well away from water,
      feed, or foodstuffs and inaccessible to animals or children.  Keep away
      from heat or open flames (18a).  Avoid contact with mouth, eyes, and
      skin (56).

      PROTECTIVE CLOTHING:  Wear neoprene rubber gloves if material could
      contact hands.  In addition to goggles, wear other clean, liquid-
      resistant protective equipment (boots, body covering, hat, face shield)
      as necessary to protect against spills or splashes (18a).  While
      handling, wear protective gloves and goggles or full face shield (56).

                       IX.  PROCEDURES FOR SPILLS AND LEAKS

                      IN CASE OF EMERGENCY, CALL, DAY OR NIGHT
                                   (800) 424-9300

      1.   Isolate the affected area and keep out unauthorized personnel.
           Avoid contact.

      2.   If anyone has been affected by Pydrin, remove the person from
           continued exposure.  Call a physician or poison control center and
           give first aid.

      3.   If the leak is indoors, ventilate the area as thoroughly as

      4.   Stop any leaks by repositioning the containers or by patching or
           otherwise repairing the leaks, but take care to avoid contact with
           the insecticide.  Pack the damaged containers in a salvage drum.
           Fill the drum with compatible cushioning and absorbent material.

      5.   Cover the spill area with a generous amount of clay or other
           absorbent materials, such as sawdust or earth.  Never use alkaline
           absorbents or soda ash in the cleanup.  Ventilate the area.  Sweep
           the contaminated absorbent onto a shovel and put the sweepings in
           another salvage drum.  If leakage occurs on soil, dig up enough of
           the surface to remove the contamination and place it in a salvage

      For Decontamination of Contaminated Areas and Equipment

           Formulated Pydrin:

           Wash down the affected areas and exposed equipment with water
           containing a mild (low-alkaline) liquid household detergent, then
           rinse with water.  Absorb waste water as above or drain it to a
           sump for future collection and disposal.  Scoop up contaminated
           absorbent and place it in the salvage drum (18a).

                               X.  LITERATURE CITED

       1.  Harding, W.C.  1979.  Pesticide profiles, part one: insecticides
               and miticides.  Univ. Maryland, Coop. Ext. Serv. Bull. 267.
               30 pp.

       8a. Thomson, W. T.  1976.  Agricultural chemicals - book 1:
               insecticides, acaricides, and ovicides.  Revised ed.  Thomson
               Publ., Indianapolis, IN.  232 pp.

      18a. Shell Chemical Company.  1981.  Agricultural chemicals safety
               manual:  Pydrin insecticide safety guide.  Houston, TX.

      25.  Morgan, D.P.  1982.  Recognition and management of pesticide
               poisonings, 3rd ed.  U.S. Environmental Protection Agency,
               Washington, DC.  120 pp.

      56.  Farm Chemicals Handbook, 70th ed.  1984.  R. T. Meister, G. L.
               Berg, C. Sine, S. Meister, and J. Poplyk, eds.  Meister
               Publishing Co., Willoughby, OH.

      62.  The Pesticide Manual:  A World Compendium, 7th ed.  1983.  C.R.
               Worthing, ed.  The British Crop Protection Council, Croydon,
               England.  695 pp.