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hexythiazox (Savey) New AI Registration NYS 2/96

February 15, 1996
Mr. Robert E. Hawk
Senior Regulatory Scientist
Gowan Company
P.O. Box 5569
Yuma, AZ 85366-5569
Dear Mr. Hawk:
Re: Registration of the New Active Ingredient
    Hexythiazox; Contained in the Pesticide Product
    Savey Ovicide/Miticide 50-WP (EPA Reg. No. 1 0 1 63-2 0 8)
Gowan Company applied to New York State for registration of Savey 
Ovicide/Miticide 50-WP (EPA Reg. No. 10163-208) which contains the new 
active ingredient hexythiazox.
Savey Ovicide/Miticide 50-WP is recommenced for use as a foliar 
application in apples and pears.  It is a 50% wettable powder 
formulation to be mixed with water and applied as a spray.  The maximum 
label rate is 3.0 ounces active ingredient per acre per season for pears 
and 1.5 ounces active ingredient per acre per season for apples.
The New York State Department of Environmental Conservation (the 
Department) has completed review of the information supplied to date in 
support of the pesticide product registration application for Savey 
Ovicide/Miticide 50-WP, which contains the new active ingredient 
hexythiazox.
Savey Ovicide/Miticide 50-WP is not toxic to fish, invertebrates, 
mammals, birds, or nontarget insects.  Neither the technical nor the 
formulated product was very toxic in acute oral, inhalation or dermal 
exposures in laboratory animals.  The technical and formulated product 
caused mild, reversible irritation to rabbit eyes, but neither were 
irritating to rabbit skin nor sensitizers in guinea pigs.
There is some evidence that hexythiazox is oncogenic in laboratory 
animals.  However, exposure of the general population to hexythiazox is 
expected to be very low given that residues in treated agricultural 
commodities are very low.  Worker exposure and risks from Savey 
Ovicide/Miticide 50-WP use are also expected to be low.
There are no chemical-specific federal or New York State drinking water 
standards for hexythiazox.  Based on the reference dose for hexythiazox 
(0.025 mg/kg/day) and United States Environmental Protection Agency 
(EPA) procedures for determining maximum contaminant level goals for 
Group C carcinogens a potential drinking water standard of 18 micrograms 
per liter (ug/L) can be calculated for hexythiazox.  This value of 1 8 
ug/L should also be considered a potential State groundwater standard.
Savey Ovicide/Miticide 50-WP should not impact groundwater in New York 
State when used according to label directions for both apples and pears.
Therefore, the Department hereby accepts for registration Savey 
Ovicide/Miticide 50-WP (EPA Reg. No. 1 0 163-2 08).  As a condition of 
this registration, we request a study summary and a copy of the EPA Data 
Evaluation Record (DER) report of the aquatic invertebrate life-cycle 
study (Guideline No. 72-2) with hexythiazox, which is-due to be 
submitted to the EPA by March 1, 1996 .
Enclosed are your New York State stamped "ACCEPTED" label and a copy of 
the Certificate of Registration.
Please contact Ms. Maureen Serafini, Supervisor of our Pesticide Product 
Registration Section, at (518) 457-7446, if you have any questions.
Sincerely,
Norman H. Nosenchuck, P.E.
Director
Division of Solid & Hazardous Materials
Enclosures
cc: w/enc.  N. Kim - NYS Dept. of Health
            A. Grey - NYS Dept. of Health
            N. Rudgers/R. Mungari - NYS Depth of Agriculture and Markets
            D. Rutz/W. Smith - Cornell University

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