hexythiazox (Savey) New AI Registration NYS 2/96
February 15, 1996
Mr. Robert E. Hawk
Senior Regulatory Scientist
P.O. Box 5569
Yuma, AZ 85366-5569
Dear Mr. Hawk:
Re: Registration of the New Active Ingredient
Hexythiazox; Contained in the Pesticide Product
Savey Ovicide/Miticide 50-WP (EPA Reg. No. 1 0 1 63-2 0 8)
Gowan Company applied to New York State for registration of Savey
Ovicide/Miticide 50-WP (EPA Reg. No. 10163-208) which contains the new
active ingredient hexythiazox.
Savey Ovicide/Miticide 50-WP is recommenced for use as a foliar
application in apples and pears. It is a 50% wettable powder
formulation to be mixed with water and applied as a spray. The maximum
label rate is 3.0 ounces active ingredient per acre per season for pears
and 1.5 ounces active ingredient per acre per season for apples.
The New York State Department of Environmental Conservation (the
Department) has completed review of the information supplied to date in
support of the pesticide product registration application for Savey
Ovicide/Miticide 50-WP, which contains the new active ingredient
Savey Ovicide/Miticide 50-WP is not toxic to fish, invertebrates,
mammals, birds, or nontarget insects. Neither the technical nor the
formulated product was very toxic in acute oral, inhalation or dermal
exposures in laboratory animals. The technical and formulated product
caused mild, reversible irritation to rabbit eyes, but neither were
irritating to rabbit skin nor sensitizers in guinea pigs.
There is some evidence that hexythiazox is oncogenic in laboratory
animals. However, exposure of the general population to hexythiazox is
expected to be very low given that residues in treated agricultural
commodities are very low. Worker exposure and risks from Savey
Ovicide/Miticide 50-WP use are also expected to be low.
There are no chemical-specific federal or New York State drinking water
standards for hexythiazox. Based on the reference dose for hexythiazox
(0.025 mg/kg/day) and United States Environmental Protection Agency
(EPA) procedures for determining maximum contaminant level goals for
Group C carcinogens a potential drinking water standard of 18 micrograms
per liter (ug/L) can be calculated for hexythiazox. This value of 1 8
ug/L should also be considered a potential State groundwater standard.
Savey Ovicide/Miticide 50-WP should not impact groundwater in New York
State when used according to label directions for both apples and pears.
Therefore, the Department hereby accepts for registration Savey
Ovicide/Miticide 50-WP (EPA Reg. No. 1 0 163-2 08). As a condition of
this registration, we request a study summary and a copy of the EPA Data
Evaluation Record (DER) report of the aquatic invertebrate life-cycle
study (Guideline No. 72-2) with hexythiazox, which is-due to be
submitted to the EPA by March 1, 1996 .
Enclosed are your New York State stamped "ACCEPTED" label and a copy of
the Certificate of Registration.
Please contact Ms. Maureen Serafini, Supervisor of our Pesticide Product
Registration Section, at (518) 457-7446, if you have any questions.
Norman H. Nosenchuck, P.E.
Division of Solid & Hazardous Materials
cc: w/enc. N. Kim - NYS Dept. of Health
A. Grey - NYS Dept. of Health
N. Rudgers/R. Mungari - NYS Depth of Agriculture and Markets
D. Rutz/W. Smith - Cornell University