Methiocarb - Chemical Profile 6/86
CHEMICAL NAME: 3,5-Dimethyl-4-(methylthio)phenol methylcarbamate
DEC INGRED. CODE:
TRADE NAME(S): Mesurol (56)
FORMULATION(S): Wettable powder, bait, hopper box t2YXW1 Seed
TYPE: Carbamate insecticide-molluscicide
BASIC PRODUCER(S): Mobay Chemical Corp.
Agricultural Chemicals Division
P.O. Box 4913
Kansas City, MO 64120
STATUS: General use. A recent EPA review of the methiocarb toxicology
data base has resulted in a reduction in the No-Effect-Level (NOEL) from
100 ppm to 5 ppm. Since it is the policy of the EPA not to establish or
maintain pesticide residue tolerances in excess of the NOEL (not above
the 5 ppm), Mobay Chemical Corporation found it necessary to delete
cherries, blueberries and peaches from the Mesurol 75% Wettable Powder
label (Mobay Chemical Corp., 4/9/85). Mobay is reviewing its data to
determine the feasibility of reducing the residues in those crops to 5.0
ppm or less by changing the use pattern.
A federal (EPA) and state registration (NYSDEC) for the use of
Mesurol has been approved for cherries and blueberries. Use
directions are as follows:
Blueberries: Apply 1 to 1.75 pounds to control maggot (adult flies)
and 2 pounds for bird repellency.
A maximum of 4 pounds of product may be applied per
season for maggot control and or bird repellency.
Applications may be made up to 7 days before harvest.
Cherries: Apply 1 to 1-1/3 pounds per acre (5.3 to 6.9 oz) for
cherry fruit fly and mite control. Apply 1-1/3 pounds
(6.9 oz) for plum curculio control.
To repell birds, apply 2 pounds per acre, 10.6 ounces
per 100 gallons. A maximum of 4 pounds of product may
be applied per acre per season. Applications may be
made up to 14 days prior to harvest. If only one ap-
plication (2 pounds of product maximum) is made in a
season, application may be made up to 3 days before
Mobay Chemical Corp., 6/17/86.
PRINCIPAL USES: Bird repellency on cherries and several states for
bird repellency on blueberries in U.S. Bird repellency on corn in
several countries. Research indicates excellent repellency on grapes,
rice, and sorghum.
Insect control on cherries includes the cherry maggot; blueberries,
blueberry maggot; grapes, yellow jackets.
Slug and snail control in and around home flower gardens and
ornamentals is also registered. Snail and Slug Pellets M-2 (Hopkins
Agricultural), Snail and Slug Bait-M (Rigo Co.) (56).
Important Pests Controlled: Thrips, slugs, snails, grasshoppers, fruit
flies, plum curculio, pear psylla, mosquitoes, mites, leafhoppers, flies,
aphids, codling moths and many others (8a).
Predominantly kills by contact activity. Fast cleanup with a long
residual activity (8a).
II. PHYSICAL PROPERTIES
MOLECULAR FORMULA: C11 H15 NO2 S (62)
MOLECULAR WEIGHT: 225.3 (62)
PHYSICAL STATE: Colorless crystalline powder (pure compound) (62)
ODOR: Mild odor (56)
MELTING POINT: 117-118 C (pure compound) (62)
VAPOR PRESSURE: 15 mPa at 60 C (pure compound) (62)
SOLUBILITY: 30 mg/l water at 20 C(pure compound) (62)
III. HEALTH HAZARD INFORMATION
OSHA STANDARD: None established
NIOSH RECOMMENDED LIMIT: None established
ACGIH RECOMMENDED LIMIT: None established
A. ACUTE TOXICITY
DERMAL: LD50 = >2000 mg/kg (rabbit) (56)
LD50 = 350-400 mg/kg (male rat) (62)
ORAL: LD50 = 15-35 mg/kg (rat, technical product) (56)
LD50 = 100 mg/kg (male rat); 40 mg/kg (guinea-pig)
INHALATION: LC50 = >20 mg/l (rat, technical product) (56)
B. SUBACUTE AND CHRONIC TOXICITY:
In 1.67-yr. feeding trials no symptom was noted in rats receiving
100 mg/kg diet (62).
IV. ENVIRONMENTAL CONSIDERATIONS
Some hazard to fish, birds and beneficial insects. Hazardous to
honey bees. Biological magnification unlikely. Some blossom thinning
may occur at high rates. Some injury reported on apples and cherries
Toxic to fish. Somewhat toxic to earthworms (8a).
Mesurol is highly toxic to bees (38b).
Approximate Residual Period: 1-2 weeks on plants (1).
V. EMERGENCY AND FIRST AID PROCEDURES
The chemical information provided below has been condensed
from original source documents, primarily from "Recognition and
Management of Pesticide Poisonings", 3rd ed. by Donald P. Morgan,
which have been footnoted. This information has been provided in
this form for your convenience and general guidance only. In
specific cases, further consultation and reference may be required
and is recommended. This information is not intended as a sub-
stitute for a more exhaustive review of the literature nor for the
judgement of a physician or other trained professional.
If poisoning is suspected, do not wait for symptoms to develop.
Contact a physician, the nearest hospital, or the nearest Poison
FREQUENT SYMPTOMS AND SIGNS OF POISONING BY CARBAMATE PESTICIDES
DIARRHEA, NAUSEA, VOMITING, ABDOMINAL PAIN, PROFUSE SWEATING,
SALIVATION, and BLURRED VISION are frequently reported. Other common
symptoms have been dyspnea, tremor, muscle twitching, ataxia, and
headache. Temporary paralysis of the extremities has also occurred.
Most reported illnesses have not exceeded a few hours, and the
prognosis is generally better than in organophosphate intoxications.
However, in severe poisonings, one should anticipate the possibility of
RESPIRATORY DEPRESSION, pulmonary edema, and convulsions. Continuing
absorption of intermediate quantities may cause protracted MALAISE,
weakness, and anorexia, resembling influenza (25).
SKIN CONTACT: Bathe and shampoo victim with soap and water if
there is any chance that skin and hair are contaminated (25).
INGESTION: If victim is alert and respiration is not
depressed, give Syrup of Ipecac, followed by 1-2 glasses of water to
induce vomiting; adults (including children over 12), 30 ml; children
(under 12 years), 15 ml (25).
INHALATION: Remove to fresh air. If not breathing, give
artificial respiration, preferably mouth to mouth. Get medical
EYE CONTACT: Wash with plenty of water for at least 15 minutes
NOTES TO PHYSICIAN:
Administer ATROPINE SULFATE intravenously, or intramuscularly if IV
injection is not possible.
In MODERATELY SEVERE poisoning: Adult dosage: 0.4-2.0 mg repeated
every 15 minutes until atropinization is achieved (tachycardia,
flushing, dry mouth, mydriasis). Maintain atropinization by repeated
doses for 2-12 hours, or longer, depending on severity of poisoning.
Dosage for children under 12 years: 0.05 mg/kg body weight repeated
every 15 minutes until atropinization is achieved. Maintain
atropinization with repeated dosage of 0.02-0.05 mg/kg.
SEVERELY POISONED individuals may exhibit remarkable tolerance to
atropine; twice the doses suggested above may be needed.
Pralidoxime (Protopam (TM)-Ayerst, 2-PAM) is of doubtful value in
poisonings by carbamate inhibitors of cholinesterase. Atropine alone
is almost always an adequate antidote (25).
VI. FIRE AND EXPLOSION INFORMATION
To be developed.
Do not apply with oil. Not compatible with alkaline compounds
(1). Compatible with most other pesticides (8a).
VIII. PROTECTIVE MEASURES
STORAGE AND HANDLING: Store in a dry place. Protect from water and
extreme heat. Store away from foods in an area designated
specifically for pesticides. Wash hands, arms, and face thoroughly
with soap and warm water before eating or smoking (38b).
PROTECTIVE CLOTHING: Wear protective clothing, natural rubber gloves,
and goggles (38b).
PROTECTIVE EQUIPMENT: Do not breathe dust, fumes, or spray mist. Wear
a mask or respirator effective for protection against carbamate
insecticides. Information as to suitable types of masks or respirators
is available from the U. S. Bureau of Mines (38b).
IX. PROCEDURES FOR SPILLS AND LEAKS
IN CASE OF EMERGENCY, CALL, DAY OR NIGHT
PESTICIDE TEAM SAFETY NETWORK/CHEMTREC
X. LITERATURE CITED
1. Harding, W.C. 1979. Pesticide profiles, part one: insecticides
and miticides. Univ. Maryland, Coop. Ext. Serv. Bull. 267.
8a. Thomson, W. T. 1976. Agricultural chemicals - book 1:
insecticides, acaricides, and ovicides. Revised ed. Thomson
Publ., Indianapolis, IN. 232 pp.
25. Morgan, D.P. 1982. Recognition and management of pesticide
poisonings, 3rd ed. U.S. Environmental Protection Agency,
Washington, DC. 120 pp.
38b. Mobay Chemical Corporation, Agricultural Chemicals Division.
1979. Technical information: Mesurol insecticide,
bird repellent-molluscicide. Kansas City, MO.
56. Farm Chemicals Handbook, 70th ed. 1984. R. T. Meister, G. L.
Berg, C. Sine, S. Meister, and J. Poplyk, eds. Meister
Publishing Co., Willoughby, OH.
62. The Pesticide Manual: A World Compendium, 7th ed. 1983. C.R.
Worthing, ed. The British Crop Protection Council, Croydon,
England. 695 pp.