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Methiocarb - Chemical Profile 6/86


      CHEMICAL NAME:      3,5-Dimethyl-4-(methylthio)phenol methylcarbamate


      TRADE NAME(S):      Mesurol (56)

      FORMULATION(S):     Wettable powder, bait, hopper box t2YXW1 Seed
                          Protectant-M (56).

      TYPE:               Carbamate insecticide-molluscicide

      BASIC PRODUCER(S):  Mobay Chemical Corp.
                          Agricultural Chemicals Division
                          P.O. Box 4913
                          Kansas City, MO 64120

      STATUS:  General use.  A recent EPA review of the methiocarb toxicology
      data base has resulted in a reduction in the No-Effect-Level (NOEL) from
      100 ppm to 5 ppm.  Since it is the policy of the EPA not to establish or
      maintain pesticide residue tolerances in excess of the NOEL (not above
      the 5 ppm), Mobay Chemical Corporation found it necessary to delete
      cherries, blueberries and peaches from the Mesurol 75% Wettable Powder
      label (Mobay Chemical Corp., 4/9/85).  Mobay is reviewing its data to
      determine the feasibility of reducing the residues in those crops to 5.0
      ppm or less by changing the use pattern.

      A federal (EPA) and state registration (NYSDEC) for the use of
      Mesurol has been approved for cherries and blueberries.  Use
      directions are as follows:
      Blueberries:  Apply 1 to 1.75 pounds to control maggot (adult flies)
                    and 2 pounds for bird repellency.
                    A maximum of 4 pounds of product may be applied per
                    season for maggot control and or bird repellency.
                    Applications may be made up to 7 days before harvest.

      Cherries:     Apply 1 to 1-1/3 pounds per acre (5.3 to 6.9 oz) for
                    cherry fruit fly and mite control.  Apply 1-1/3 pounds
                    (6.9 oz) for plum curculio control.
                    To repell birds, apply 2 pounds per acre, 10.6 ounces
                    per 100 gallons.  A maximum of 4 pounds of product may
                    be applied per acre per season.  Applications may be
                    made up to 14 days prior to harvest.  If only one ap-
                    plication (2 pounds of product maximum) is made in a
                    season, application may be made up to 3 days before

                    Mobay Chemical Corp., 6/17/86.

      PRINCIPAL USES:  Bird repellency on cherries and several states for
      bird repellency on blueberries in U.S.  Bird repellency on corn in
      several countries.  Research indicates excellent repellency on grapes,
      rice, and sorghum.
           Insect control on cherries includes the cherry maggot; blueberries,
      blueberry maggot; grapes, yellow jackets.
           Slug and snail control in and around home flower gardens and
      ornamentals is also registered.  Snail and Slug Pellets M-2 (Hopkins
      Agricultural), Snail and Slug Bait-M (Rigo Co.) (56).

                                   I.  EFFICACY

      Important Pests Controlled:  Thrips, slugs, snails, grasshoppers, fruit
      flies, plum curculio, pear psylla, mosquitoes, mites, leafhoppers, flies,
      aphids, codling moths and many others (8a).
           Predominantly kills by contact activity.  Fast cleanup with a long
      residual activity (8a).

                             II.  PHYSICAL PROPERTIES

      MOLECULAR FORMULA:  C11 H15 NO2 S (62)

      MOLECULAR WEIGHT:   225.3 (62)

      PHYSICAL STATE:     Colorless crystalline powder (pure compound) (62)

      ODOR:               Mild odor (56)

      MELTING POINT:      117-118 C (pure compound) (62)

      VAPOR PRESSURE:     15 mPa at 60 C (pure compound) (62)

      SOLUBILITY:         30 mg/l water at 20 C(pure compound) (62)

                           III.  HEALTH HAZARD INFORMATION

      OSHA STANDARD:  None established

      NIOSH RECOMMENDED LIMIT:  None established

      ACGIH RECOMMENDED LIMIT:  None established


           A.  ACUTE TOXICITY

               DERMAL:  LD50 = >2000 mg/kg (rabbit) (56)
                        LD50 = 350-400 mg/kg (male rat) (62)

               ORAL:    LD50 = 15-35 mg/kg (rat, technical product) (56)
                        LD50 = 100 mg/kg (male rat); 40 mg/kg (guinea-pig)

               INHALATION:  LC50 = >20 mg/l (rat, technical product) (56)


           In 1.67-yr. feeding trials no symptom was noted in rats receiving
      100 mg/kg diet (62).

                        IV.  ENVIRONMENTAL  CONSIDERATIONS

            Some hazard to fish, birds and beneficial insects.  Hazardous to
      honey bees.  Biological magnification unlikely.  Some blossom thinning
      may occur at high rates.  Some injury reported on apples and cherries
            Toxic to fish.  Somewhat toxic to earthworms (8a).
            Mesurol is highly toxic to bees (38b).

      Approximate Residual Period:  1-2 weeks on plants (1).


           The chemical information provided below has been condensed
      from original source documents, primarily from "Recognition and
      Management of Pesticide Poisonings", 3rd ed. by Donald P.  Morgan,
      which have been footnoted.  This information has been provided in
      this form for your convenience and general guidance only.  In
      specific cases, further consultation and reference may be required
      and is recommended.  This information is not intended as a sub-
      stitute for a more exhaustive review of the literature nor for the
      judgement of a physician or other trained professional.

           If poisoning is suspected, do not wait for symptoms to develop.
      Contact a physician, the nearest hospital, or the nearest Poison
      Control Center.


      SALIVATION, and BLURRED VISION are frequently reported.  Other common
      symptoms have been dyspnea, tremor, muscle twitching, ataxia, and
      headache.  Temporary paralysis of the extremities has also occurred.
      Most reported illnesses have not exceeded a few hours, and the
      prognosis is generally better than in organophosphate intoxications.
      However, in severe poisonings, one should anticipate the possibility of
      RESPIRATORY DEPRESSION, pulmonary edema, and convulsions.  Continuing
      absorption of intermediate quantities may cause protracted MALAISE,
      weakness, and anorexia, resembling influenza (25).

           SKIN CONTACT:  Bathe and shampoo victim with soap and water if
      there is any chance that skin and hair are contaminated (25).

           INGESTION:  If victim is alert and respiration is not
      depressed, give Syrup of Ipecac, followed by 1-2 glasses of water to
      induce vomiting; adults (including children over 12), 30 ml; children
      (under 12 years), 15 ml (25).

           INHALATION:  Remove to fresh air.  If not breathing, give
      artificial respiration, preferably mouth to mouth.  Get medical
      attention (38b).

           EYE CONTACT:  Wash with plenty of water for at least 15 minutes


      Administer ATROPINE SULFATE intravenously, or intramuscularly if IV
      injection is not possible.
      In MODERATELY SEVERE poisoning:  Adult dosage:  0.4-2.0 mg repeated
      every 15 minutes until atropinization is achieved (tachycardia,
      flushing, dry mouth, mydriasis).  Maintain atropinization by repeated
      doses for 2-12 hours, or longer, depending on severity of poisoning.
      Dosage for children under 12 years:  0.05 mg/kg body weight repeated
      every 15 minutes until atropinization is achieved.  Maintain
      atropinization with repeated dosage of 0.02-0.05 mg/kg.
      SEVERELY POISONED individuals may exhibit remarkable tolerance to
      atropine; twice the doses suggested above may be needed.
      Pralidoxime (Protopam (TM)-Ayerst, 2-PAM) is of doubtful value in
      poisonings by carbamate inhibitors of cholinesterase.  Atropine alone
      is almost always an adequate antidote (25).

                        VI.  FIRE AND EXPLOSION INFORMATION

           To be developed.

                                VII.  COMPATIBILITY

           Do not apply with oil.  Not compatible with alkaline compounds
      (1).  Compatible with most other pesticides (8a).

                            VIII.  PROTECTIVE MEASURES

      STORAGE AND HANDLING:  Store in a dry place.  Protect from water and
      extreme heat.  Store away from foods in an area designated
      specifically for pesticides.  Wash hands, arms, and face thoroughly
      with soap and warm water before eating or smoking (38b).

      PROTECTIVE CLOTHING:  Wear protective clothing, natural rubber gloves,
      and goggles (38b).

      PROTECTIVE EQUIPMENT: Do not breathe dust, fumes, or spray mist.  Wear
      a mask or respirator effective for protection against carbamate
      insecticides.  Information as to suitable types of masks or respirators
      is available from the U. S. Bureau of Mines (38b).

                       IX.  PROCEDURES FOR SPILLS AND LEAKS

                                  (800) 424-9300

                               X.  LITERATURE CITED

       1.  Harding, W.C.  1979.  Pesticide profiles, part one: insecticides
               and miticides.  Univ. Maryland, Coop. Ext. Serv. Bull. 267.
               30 pp.

       8a. Thomson, W. T.  1976.  Agricultural chemicals - book 1:
               insecticides, acaricides, and ovicides.  Revised ed.  Thomson
               Publ., Indianapolis, IN.  232 pp.

      25.  Morgan, D.P.  1982.  Recognition and management of pesticide
               poisonings, 3rd ed.  U.S. Environmental Protection Agency,
               Washington, DC.  120 pp.

      38b. Mobay Chemical Corporation, Agricultural Chemicals Division.
               1979.  Technical information:  Mesurol insecticide,
               bird repellent-molluscicide.  Kansas City, MO.

      56.  Farm Chemicals Handbook, 70th ed.  1984.  R. T. Meister, G. L.
               Berg, C. Sine, S. Meister, and J. Poplyk, eds.  Meister
               Publishing Co., Willoughby, OH.

      62.  The Pesticide Manual:  A World Compendium, 7th ed.  1983.  C.R.
               Worthing, ed.  The British Crop Protection Council, Croydon,
               England.  695 pp.