methoprene (Altosid) Chemical Profile 4/85
CHEMICAL NAME: Isopropyl (2E-4E)-11-methoxy-3,7,11-trimethyl-
DEC INGRED. CODE:
TRADE NAME(S): Altosid, Apex, Diacon, Dianex, Kabat, Minex,
Pharorid, Precor (56).
FORMULATION(S): Altosid SR-10, a special slow release formulation
containing 10% active ingredient, has been developed for mosquito
-Altosid Briquets, a special slow release formulation containing 4%
-Altosid CP-10, a premix containing 10% active ingredient, to be
incorporated into cattle supplements for feed-through hornfly control.
-Apex 5E for control of sciarid flies in mushroom houses.
-Diacon for control of stored products pests on peanuts.
-Dianex Residual Spray to control stored product pests in food and
tobacco processing plants and warehouses.
-Kabat Tobacco Protector for protection of stored tobacco from
damage by cigarette beetle and tobacco moth.
-Minex 5E for control of leafminers in chrysanthemums grown in
greenhouses or other shaded growing areas.
-Pharorid Bait premix for pharoah's ant control registered in the
United Kingdom and U.S.
-Precor 5E for control of indoor dog and cat flea populations.
-Precor Fogger for control of indoor dog and cat flea populations (56).
TYPE: Insect growth regulator
BASIC PRODUCER(S): Zoecon Corp.
975 California Ave.
Palo Alto, CA 94304
STATUS: General use
PRINCIPAL USES: Insect growth regulator (especially active against
coleoptera, diptera, homoptera, and siphonaptera). Selective
mosquito larvicide (56).
Important Pests Controlled: Flies, moths, ants, boll weevil, lice,
leafhoppers, mosquitoes, plant hoppers, cucumber beetle, cigarette
beetle, tobacco moth and others (8a).
Especially effective against flies. Stable but non-persistent.
Effective at very low rates. Growth regulators such as these cause the
insects not to mature to the adult stage of growth so they cannot
reproduce. Shows little or no effect on the adult or pupal stage of
insect development (8a).
Unlike ordinary insecticides, this relatively non-persistent
chemical exhibits morphological rather than direct toxic activity (56).
II. PHYSICAL PROPERTIES
MOLECULAR FORMULA: C19 H34 O3 (62)
MOLECULAR WEIGHT: 310.5 (62)
PHYSICAL STATE: Amber liquid (pure compound) (62)
BOILING POINT: 100 C/0.05 mmHg (pure compound) (62)
VAPOR PRESSURE: 3.15 mPa at 25 C (pure compound) (62)
SOLUBILITY: 1.4 mg/l water (pure compound) (62)
III. HEALTH HAZARD INFORMATION
OSHA STANDARD: None established
NIOSH RECOMMENDED LIMIT: None established
ACGIH RECOMMENDED LIMIT: None established
A. ACUTE TOXICITY
DERMAL: LD50 = 3500 mg/kg, nonirritating to skin (rabbit) (62).
ORAL: LD50 = >34600 mg/kg (rat), 5000-10000 mg/kg (dog) (62).
INHALATION: LC50 = >210 mg/l (rat) (56)
EYES: Nonirritating to eye (rabbit) (62)
B. SUBACUTE AND CHRONIC TOXICITY:
In 2-yr feeding trials no methoprene-related effects were observed:
with rats at 5000 mg/kg diet; with mice at 250 mg/kg diet. No effect was
observed at the highest rates tested: in 3-generation reproduction
studies in rats (2500 mg/kg diet); teratogenicity in rabbits (500 mg/kg)
or rats (1000 mg/kg); mutagenicity in rats (2000 mg/kg) (62).
IV. ENVIRONMENTAL CONSIDERATIONS
Little or no hazard to birds and fish. No biological magnification.
No phytotoxicity to date (1).
Somewhat toxic to fish. Shrimp and crabs may be killed. Relatively
non-toxic to non-target species (8a).
Acute static fish toxicity showed TL50's of 4.62 ppm on bluegill;
4.39 ppm on trout (106 ppm when water is aerated); and greater than 100
ppm on channel catfish (56).
Approximate Residual Period: Relatively nonpersistent (1).
V. EMERGENCY AND FIRST AID PROCEDURES
The chemical information provided below has been condensed
from original source documents, primarily from "Recognition and
Management of Pesticide Poisonings", 3rd ed. by Donald P. Morgan,
which have been footnoted. This information has been provided in
this form for your convenience and general guidance only. In
specific cases, further consultation and reference may be required
and is recommended. This information is not intended as a sub-
stitute for a more exhaustive review of the literature nor for the
judgement of a physician or other trained professional.
If poisoning is suspected, do not wait for symptoms to develop.
Contact a physician, the nearest hospital, or the nearest Poison
To be developed.
VI. FIRE AND EXPLOSION INFORMATION
To be developed.
Ordinarily would not be mixed with other materials (1). Do not
mix with oil. Do not combine with other pesticides (8a).
VIII. PROTECTIVE MEASURES
To be developed.
IX. PROCEDURES FOR SPILLS AND LEAKS
IN CASE OF EMERGENCY, CALL, DAY OR NIGHT
PESTICIDE TEAM SAFETY NETWORK/CHEMTREC
X. LITERATURE CITED
1. Harding, W.C. 1979. Pesticide profiles, part one: insecticides
and miticides. Univ. Maryland, Coop. Ext. Serv. Bull. 267.
8a. Thomson, W. T. 1976. Agricultural chemicals - book 1:
insecticides, acaricides, and ovicides. Revised ed. Thomson
Publ., Indianapolis, IN. 232 pp.
56. Farm Chemicals Handbook, 70th ed. 1984. R. T. Meister, G. L.
Berg, C. Sine, S. Meister, and J. Poplyk, eds. Meister
Publishing Co., Willoughby, OH.
62. The Pesticide Manual: A World Compendium, 7th ed. 1983. C.R.
Worthing, ed. The British Crop Protection Council, Croydon,
England. 695 pp.