piperonyl butoxide Chemical Profile 3/85
CHEMICAL NAME: 3,4-methylenedioxy-6-propylbenzyl (heptyl) diethylene
glycol ether (56)
DEC INGRED. CODE:
TRADE NAME(S): Butacide (56)
FORMULATION(S): Used as a synergist in conjunction with pyrethrin,
allethrin, and other synthetic pyrethroids, etc., in ratios ranging
from 3:1 to 20:1 by weight, as pressurized sprays, solutions, emulsions,
foggers, dusts, wettable powders, paper coatings, and E.C. for tank
mix (Fairfield American, Penick); E.C. 8 pounds/gallon (McLaughlin
Gormley King) (56).
TYPE: Organic synergist
BASIC PRODUCER(S): Fairfield American Corp. Prentiss Drug & Chem. Co
3932 Salt Road 3673 Seventh Ave.
Medina, NY 14103 New York, NY 10001
McLaughlin Gormley King Co.
8810 Tenth Ave. North
Minneapolis, MN 55427
STATUS: General use. RPAR: criteria possibly met or exceeded:
co-carcinogenicity, carcinogenicity. Decision document complete. FR
notice 47 FR 20376 published 5/12/82. NTIS # PB83-0137901. Returned
to the Registration Process on May 12, 1982. Section 3(c)(2)(B) Notice
requesting additional data issued on Sept. 30, 1983 (22).
PRINCIPAL USES: Highly synergistic action on pyrethrins, allethrin,
tetramethrin, rotenone, and others when combined with these insecticides
To be developed.
II. PHYSICAL PROPERTIES
MOLECULAR FORMULA: C19 H30 O5 (62)
MOLECULAR WEIGHT: 338.4 (62)
PHYSICAL STATE: Pale yellow oil (technical product) (62)
BOILING POINT: 180 C/l mmHg (technical product) (62)
SOLUBILITY: Not soluble in water (56)
III. HEALTH HAZARD INFORMATION
OSHA STANDARD: None established
NIOSH RECOMMENDED LIMIT: None established
ACGIH RECOMMENDED LIMIT: None established
A. ACUTE TOXICITY
DERMAL: LD50 = >1880 mg/kg (1)
ORAL: LD50 = c. 7500 mg/kg (rat, rabbit) (62)
LD50 = >7500 mg/kg (rat) (56)
B. SUBACUTE AND CHRONIC TOXICITY:
In 2-yr feeding trials rats receiving 100 mg/kg diet suffered no
It is noncarcinogenic and the safe human tolerance for chronic
ingestion is estimated at 42 mg/kg diet (62).
IV. ENVIRONMENTAL CONSIDERATIONS
Little or no hazard to birds, fish and beneficial insects (1).
Approximate Residual Period: Short-lived compound; when combined with
pyrethrins and some others gives good knockdown and kill (1).
V. EMERGENCY AND FIRST AID PROCEDURES
The chemical information provided below has been condensed
from original source documents, primarily from "Recognition and
Management of Pesticide Poisonings", 3rd ed. by Donald P. Morgan,
which have been footnoted. This information has been provided in
this form for your convenience and general guidance only. In
specific cases, further consultation and reference may be required
and is recommended. This information is not intended as a sub-
stitute for a more exhaustive review of the literature nor for the
judgement of a physician or other trained professional.
If poisoning is suspected, do not wait for symptoms to develop.
Contact a physician, the nearest hospital, or the nearest Poison
FREQUENT SYMPTOMS AND SIGNS OF UNDUE EXPOSURE TO PYRETHRUM, PYRETHRINS,
PYRETHROIDS, AND PIPERONYL BUTOXIDE
A STUFFY, RUNNY NOSE and scratchy throat from inhalation of partly
purified pyrethrum extract is the most common adverse effect of these
agents. Asthmatic WHEEZING may be precipitated by exposure of
predisposed individuals. Sudden bronchospasm, swelling of oral and
laryngeal mucous membranes, and shock (anaphylaxis) have been reported
after pyrethrum inhalation. Delayed appearance of dyspnea, cough and
fever, with patchy lung infiltrates on x-ray, suggest hypersensitivity
pneumonitis. Nervous irritability, tremors, and ataxia have occurred
rarely in persons who have had massive inhalation exposure to
pyrethrins. Halocarbon propellents in bug-bomb products present a risk
of CARDIAC ARRHYTHMIA and possibly fibrillation if inhaled to excess.
Hydrocarbons used as solvents in spray products are likely to result in
COUGH, FEVER, and CHEST PAIN (hydrocarbon pneumonitis) if these liquids
are inadvertently aspirated (25).
INGESTION: If large amounts of pyrethroid formulation (>5
mg/kg) have been ingested:
If victim is alert and respiration is not depressed, give Syrup of
Ipecac followed by 1-2 glasses of water to induce vomiting (adults and
children 12 years and older: 30 ml; children under 12 years: 15 ml) (25).
EYE CONTACT: Wash contaminating pesticide from the eye with
copious amounts of water. Wash contaminated skin with soap and water
NOTES TO PHYSICIAN:
If victim is not fully alert, empty stomach immediately by intubation,
aspiration, and lavage, using isotonic saline or 5% sodium bicarbonate.
Because many pesticides are dissolved in petroleum distillates, emesis
and intubation of the stomach involve a risk that solvent will be
aspirated, leading to chemical pneumonitis. Do not administer or
instill milk, cream, or other substances containing vegetable or animal
fats, which enhance absorption of lipophilic substances, such as
pyrethrins and pyrethroids.
Diazepam (Valium) 5-10 mg in adults, 0.1 mg/kg in children, given
orally or slowly IV, should control nervousness and tremors in rare
cases having these symptoms after extraordinary exposure to pyrethrins
and pyrethroids (25).
VI. FIRE AND EXPLOSION INFORMATION
To be developed.
To be developed.
VIII. PROTECTIVE MEASURES
STORAGE AND HANDLING: Ordinary good manufacturing practices and
sanitation. Ventilate well. Store in closed drum in cool, dry place
PROTECTIVE CLOTHING: None (56).
IX. PROCEDURES FOR SPILLS AND LEAKS
IN CASE OF EMERGENCY, CALL, DAY OR NIGHT
PESTICIDE TEAM SAFETY NETWORK/CHEMTREC
X. LITERATURE CITED
1. Harding, W.C. 1979. Pesticide profiles, part one: insecticides
and miticides. Univ. Maryland, Coop. Ext. Serv. Bull. 267.
25. Morgan, D.P. 1982. Recognition and management of pesticide
poisonings, 3rd ed. U.S. Environmental Protection Agency,
Washington, DC. 120 pp.
56. Farm Chemicals Handbook, 70th ed. 1984. R. T. Meister, G. L.
Berg, C. Sine, S. Meister, and J. Poplyk, eds. Meister
Publishing Co., Willoughby, OH.
62. The Pesticide Manual: A World Compendium, 7th ed. 1983. C.R.
Worthing, ed. The British Crop Protection Council, Croydon,
England. 695 pp.