pirimicarb (Pirimor) Chemical Profile 4/85
CHEMICAL NAME: 2-Dimethylamino-5,6-dimethylpyrimidin-4-yl dimethyl-
DEC INGRED. CODE:
TRADE NAME(S): Pirimor, Abol, Aficida, Aphox, Fernos, Rapid (56)
FORMULATION(S): Dispersible grains, dispersible powders, emulsifiable
concentrates, aerosol, ULV spray, smoke generator
TYPE: Carbamate insecticide (aphicide)
BASIC PRODUCER(S): ICI Plant Protection Division
Surrey GU27 3JE England
STATUS: General use
PRINCIPAL USES: A fast-acting selective aphicide useful against both
OP-resistant and non-OP-resistant strains. It acts by contact,
translaminar, vapor, and systemic action. Used on a wide range of
crops including cereals, sugar beet, potatoes, fruit, vegetables. It
is relatively nontoxic to beneficial predators, parasites, and bees (56).
Important Pests Controlled: Aphids, flies and many others (8a).
Fast acting. Relatively short residual. Very selective. Has a
quick knockdown effect. Ideal for use in greenhouses (8a).
II. PHYSICAL PROPERTIES
MOLECULAR FORMULA: C11 H18 N4 O2 (62)
MOLECULAR WEIGHT: 238.3 (62)
PHYSICAL STATE: Colorless solid (pure compound) (62)
ODOR: None (20a)
MELTING POINT: 90.5 C (pure compound) (62)
VAPOR PRESSURE: 4.0 mPa at 30 C (pure compound) (62)
SOLUBILITY: 2.7 g/l water at 25 C (pure compound) (62)
III. HEALTH HAZARD INFORMATION
OSHA STANDARD: None established
NIOSH RECOMMENDED LIMIT: None established
ACGIH RECOMMENDED LIMIT: None established
A. ACUTE TOXICITY
DERMAL: LD50 = >500 mg/kg (rat) (56); nonirritant (20a).
ORAL: LD50 = 147 mg/kg (rat) (56)
LD50 = 107 mg/kg (mouse); 25-50 mg/kg (poultry);
100-200 mg/kg (dog) (62).
EYES: Pirimor caused no irritation when introduced as a 5%
solution of technical material into the eyes of
B. SUBACUTE AND CHRONIC TOXICITY:
Rat: No ill effects were detected when rats were fed 750 ppm for 90
Dog: In feeding tests for a period of 90 days, a no-effect level of
1.8 mg/kg was demonstrated.
Daily application of 500 mg/kg to rabbits (dermally) for 24 hours
over a 14 day period produced no toxic signs during the experiment or
during the next 14 days (20a).
Rats exposed for 6 hr/d (5 d/week) for 21 d, to air which had been
passed over technical pirimicarb at room temperature developed no toxic
sign, nor was there inhibition of cholinesterase. Daily applications of
500 mg/kg (for 24-hr) to rabbit skin over a 14-day period produced no
toxic symptom. In 2-yr feeding trials NEL was: for dogs 1.8 mg/kg daily;
for rats 250 mg/kg diet (12.5 mg/kg daily) (62).
IV. ENVIRONMENTAL CONSIDERATIONS
Some hazard to fish, birds, and beneficial insects. Some hazard to
honey bees. Biological magnification unlikely. Nonphytotoxic (1).
Does not harm lady bugs or lacewings. Low bee toxicity (8a).
LC50 (96-hr) is: for bluegill 55 mg/l; for rainbow trout 29 mg/l.
Acute oral LD50 for mallard duck 17.2 mg/kg; for bobwhite quail 8.2 mg/kg
Approximate Residual Period: Relatively short in plants; broken down
rapidly by ultraviolet light (1).
V. EMERGENCY AND FIRST AID PROCEDURES
The chemical information provided below has been condensed
from original source documents, primarily from "Recognition and
Management of Pesticide Poisonings", 3rd ed. by Donald P. Morgan,
which have been footnoted. This information has been provided in
this form for your convenience and general guidance only. In
specific cases, further consultation and reference may be required
and is recommended. This information is not intended as a sub-
stitute for a more exhaustive review of the literature nor for the
judgement of a physician or other trained professional.
If poisoning is suspected, do not wait for symptoms to develop.
Contact a physician, the nearest hospital, or the nearest Poison
FREQUENT SYMPTOMS AND SIGNS OF POISONING BY CARBAMATE PESTICIDES
DIARRHEA, NAUSEA, VOMITING, ABDOMINAL PAIN, PROFUSE SWEATING,
SALIVATION, and BLURRED VISION are frequently reported. Other common
symptoms have been dyspnea, tremor, muscle twitching, ataxia, and
headache. Temporary paralysis of the extremities has also occurred.
Most reported illnesses have not exceeded a few hours, and the
prognosis is generally better than in organophosphate intoxications.
However, in severe poisonings, one should anticipate the possibility of
RESPIRATORY DEPRESSION, pulmonary edema, and convulsions. Continuing
absorption of intermediate quantities may cause protracted MALAISE,
weakness, and anorexia, resembling influenza (25).
SKIN CONTACT: Wash with soap and water (25).
INGESTION: If victim is alert and respiration is not depressed,
give Syrup of Ipecac, followed by 1-2 glasses of water to induce
vomiting; adults (including children over 12), 30 ml; children (under
12 years), 15 ml (25).
NOTES TO PHYSICIAN:
For severe poisoning atropine is an antidote and should be given
immediately intramuscularly at a level of 1 to 4 mg and then 2 mg every
30 minutes. The patient must be kept fully atropinized. Oxime
reactivators (pralidoxime, P-25, P-2-AM) are not effective. Oxygen
and artificial respiration may be required (20a).
VI. FIRE AND EXPLOSION INFORMATION
To be developed.
Compatible with most materials (1).
VIII. PROTECTIVE MEASURES
STORAGE AND HANDLING: No special handling precautions are necessary
during conventional spraying. Remove contaminated clothing and launder
before re-use. Wash thoroughly after handling. Avoid breathing dust
or spray mist. Avoid contact with eyes (20a).
PROTECTIVE CLOTHING: Gloves, overalls (21a).
IX. PROCEDURES FOR SPILLS AND LEAKS
IN CASE OF EMERGENCY, CALL, DAY OR NIGHT
PESTICIDE TEAM SAFETY NETWORK/CHEMTREC
X. LITERATURE CITED
1. Harding, W.C. 1979. Pesticide profiles, part one: insecticides
and miticides. Univ. Maryland, Coop. Ext. Serv. Bull. 267.
8a. Thomson, W. T. 1976. Agricultural chemicals - book 1:
insecticides, acaricides, and ovicides. Revised ed. Thomson
Publ., Indianapolis, IN. 232 pp.
20a. ICI United States, Inc. 1976. Technical information: Pirimor
insecticide. Goldsboro, NC.
21a. Agricultural Canada, Products and Marketing Branch, Plant Products
Division. 1972. Registration of a new pesticide:
pirimicarb. Ottawa, Ontario, Canada.
25. Morgan, D.P. 1982. Recognition and management of pesticide
poisonings, 3rd ed. U.S. Environmental Protection Agency,
Washington, DC. 120 pp.
56. Farm Chemicals Handbook, 70th ed. 1984. R. T. Meister, G. L.
Berg, C. Sine, S. Meister, and J. Poplyk, eds. Meister
Publishing Co., Willoughby, OH.
62. The Pesticide Manual: A World Compendium, 7th ed. 1983. C.R.
Worthing, ed. The British Crop Protection Council, Croydon,
England. 695 pp.