propargite (Omite, Comite) Chemical Fact Sheet 9/86
CHEMICAL FACT SHEET FOR:
FACT SHEET NUMBER: 99
DATE ISSUED: SEPTEMBER 30, 1986
1. DESCRIPTION OF CHEMICAL
- Generic Name: 2-(p-tert-butylphenoxy)cyclohexyl 2-propynyl sulfite
- Common Name: Propargite
- Trade Names: OmiteTM, ComiteTM, and Uniroyal D014
- EPA Shaughnessy Code: 097601
- Pesticide Type: Acaricide
- Year of Initial Registration: 1966
- Chemical Family: Organosulfite
- U.S. Producer: Uniroyal Chemical Company
2. USE PATTERNS AND FORMULATION
- Application Sites: Terrestrial food crops (field, vegetable, aquatic
food crop (cranberry); and greenhouse nonfood crops (ornamentals).
- Types of Formulations: Single active ingredient (a.i.) formulations
consist of 4% dust; 3% and 30% wettable powders; 5, 6 and 6.55
pounds per gallon emulsifiable concentrate. The technical formulation
u is 85%a.i., and the formulation intermediate is 25% a.i.
- Types and Methods of Application: End-use product is applied foliarly
using air and/or ground equipment (including air blast).
- Application Rates: Application rate ranges from 0.75 to 6.75 lb
active ingredient per acre.
- Usual Carrier: Water
3. SCIENCE FINDINGS
- Physical State: Viscous liquid
- Color: Dark Amber
- Odor: Faint solvent odor to very faint solvent odor.
- Density: Specific gravity = 1.085 - 1.115 at 25 C; Bulk density =
- Solubility: In water, about 0.5 ppm at 25 C., miscible with organic
solvents such as acetone, benzene, and ethanol.
- Stability: No evidence of breakdown in one year.
- Flash Point: At least 38.5 degrees C.
- Acute effects
- Adequate data are not available to fully assess the toxicity of
Propargite. While, in general, propargite is not highly toxic
(Category III oral, dermal and inhalation), it is in toxicity
Category I for primary eye and skin irritation. Available data
present only supplementary information (as set fourth below), and
additional data must be submitted.
- Acute Oral Toxicity (Rat): 2.2 g/kg
- Acute Dermal Toxicity (Rabbit): 3.16(1.63-6.15) ml/kg
- Acute Inhalation: > 2.5 mg/l
- Primary Eye Irritation: Corneal effects that were not reversible
after 14 days were observed in four of six rabbits.
- Dermal Sensitization: Inconclusive
- Subchronic Dermal Toxicity: Inconclusive
- Chronic Effects
- Teratogenicity (Rabbit): Maternal NOEL = 2 mg/kg/day. Maternal
LEL s 6 mg/kg/day (reduced body weight gain). Developmental
Toxicity NOEL = 2 mg/kg/day; developmental (increased resorption,
reduced body weight, and delayed ossification). A/D ratio =
maternal LEL/Developmental = 2/2 = 1.
- 3-Gen. Reproduction (Rat): Noel > 300 ppm. Additional
data is required. Only one dose used throughout the study.
- Mutagenicity: Inconclusive. Additional categories of
mutagenicity testing are required.
- Chronic Feeding/Oncogenicity (Dog): NOEL = 900 ppm (HDT). No
adverse effects were observed by the hematology, blood chemistry
determinations or urine examinations.
- Feeding/Oncogenicity: Inconclusive. The study is classified as
Supplementary because too few animals were examined histologically
at 900 and 2000 ppm. This study needs to be repeated.
- Metabolism: Inconclusive. Additional data is required.
- Other Toxicological Effects
- Propargite is not an organophosphate chemical; therefore, it does
not have a neurotoxic potential, and a neurotoxicity study is not
- Major Routes of Exposure
- There is a potential for dermal, ocular and inhalation exposure
from mixing concentrates and applying spray mixtures.
Physiological and biochemical behavior characteristics
- Foliar Absorption: Data are not available to evaluate the effects
of propargite in plants.
- Translocation: Data are not available to evaluate the translocation
- Mechanism of Pesticidal Actions: Mode of activity involves residual
- Available data are insufficient to fully assess the environmental
fate of propargite. From the data that exists, however, there seems
to be no reason for concern about the leaching of the parent
chemical into groundwater.
- Avian Oral Toxicity: Mallard duck - > 4640 ppm.
- Avian Dietary Toxicity: Bobwhite quail - 3401 ppm;
Mallard duck - > 4640 ppm.
- Avian Reproduction: Data are inconclusive to determine the effects
on avian reproduction. Additional data are required.
- Freshwater Fish Toxicity: Bluegill Sunfish - 0.167 ppm;
Rainbow trout - 0.118 ppm.
- Aquatic Invertebrates (freshwater): Daphnia magna - 0.092 ppm.
- Aquatic Invertebrates (lifecycle): Daphia magna - 0.009 - 0.014 ppm.
- Available data indicate that propargite is practically nontoxic to
avian species. Propargite is highly toxic to fish.
- Tolerances have been established for residues of propargite in raw
agricultural commodities, milk, eggs, meat, fat and meat by-products
(40 CFR 180.259).
Commodity Parts Per Million (ppm)
Almonds, hulls 55.0
Beans, dry 0.2
Beans, succulent 20.0
Cattle, fat 0.1
Cattle, MBYP 0.1
Cattle, meat 0.1
Corn, fodder 10.0
Corn, forage 10.0
Corn, fresh (incl. sweet) (K+CWHR) 0.1
Corn, grain 0.1
Eggs o 1
Figs (fresh) 3.0
Goats, fats 0.1
Goats, meat 0.1
Hogs, fat 0.1
Hogs, meat 0.1
Horses, fat 0.1
Horses, MBYP 0.1
Horses, meat 0.1
Lemons 5 0
Milkfat (0.08 in whole milk) 2.0
Peaches 7 0
Peanuts, forage 10.0
Peanuts, hay 10.0
Peanuts, hulls 10.0
Plums (fresh prunes) 7.0
Poultry, fat 0.1
Poultry, MBYP 0.1
Poultry, meat 0.1
Sheep, fat 0.1
Sheep, MBYP 0.1
Sheep, meat 0.1
Sorghum, fodder 10.0
Sorghum, forage 10.0
Tea (dry) 10.0
- Results of the Tolerance Assessment: Because chronic feeding/
oncogenicity and reproduction studies are needed, the current PADI is
set on a 2-year dog feeding study a systemic NOEL at the highest dose
tested (900 ppm). At the highest dose tested, there were no effects
observed. With a safety factor of 1000, the TMRC is currently 112% of
the PADI. The TMRC, however, is based on the assumption that 100% of
the crop for which a tolerance is established is treated with
propargite, which is not the case. If the TMRC is adjusted to reflect
the actual percentage of crop treated, the TMRC would be reduced to a
percentage level of the PADI significantly lower than 112%.
Therefore, the public should be in no danger from dietary exposure
while the Agency awaits data.
Problems Known to Have Occurred with Use of the Chemical
Summary Science Statement
- Propargite is not considered at this time to be oncogenic. Propargite
has a low acute (Category III) oral, dermal, inhalation toxicity. It
is in toxicity category I however, for primary eye and primary skin
irritation, and cases of severe dermatitis afflicting workers
reentering treated sites have been reported. Chronic testing reveals
that propargite appears to have little effect on laboratory animals
except at higher dosage levels; effects reported include depressed
body weights and rates of weight gain. Oral subchronic test results
appear to parallel those for chronic testing. Propargite is not
teratogenic in rabbits and rats. Insufficient data exist to fully
assess the dermal sensitization, subchronic dermal toxicity,
subchronic inhalation toxicity, and mutagenicity of propargite.
Additional metabolism testing is also necessary. Propargite is
relatively nontoxic to honey bees and avian species. It is very
highly toxic to freshwater fish. The actual threat to aquatic
organisms at this time cannot be accurately assessed due to the
insufficiency of environmental fate data. Field monitoring data to
determine propargite residues in water from terrestrial applications
is needed as is additional testing to determine the effects of end-use
products on coldwater and warmwater species of fish, aquatic
invertebrates, and estuarine and marine organisms. The metabolism of
propargite in both plants and animals is not sufficiently understood;
additional metabolism data are necessary. Storage stability data are
also necessary, as well as additional crop residue data and processing
studies for certain crops registered for propargite use.
4. SUMMARY OF REGULATORY POSITIONS AND RATIONALES
- The following are warning statements that must be included on
propargite pesticide labels.
- Manufacturing Use Products
- Under the Environmental Hazard Statement, add the following
- "This pesticide is toxic to fish. Do not discharge effluent
containing this product into lakes, streams, ponds, estuaries,
oceans, or public water unless this product is specifically
identified and addressed in an NPDES permit. Do not discharge
effluent containing this product into sewer systems without
previously notifying the sewage treatment plant authority.
for guidance, contact your State Water Board or Regional
Office of the EPA."
- Protective Clothing Statement
- "Mixer/loaders must wear goggles or a face shield, chemical-
resistant apron, long-sleeved shirt and long pants or
coveralls, and mid-forearm to elbow length chemical-resistant
gloves when mixing, loading, or otherwise handling the
- End-Use Products
- Products with Aquatic Use(s): Under the Environmental Hazard
Statement, add the following precaution:
- "This pesticide is toxic to fish. Do not apply directly to
water except as specified on this label. Drift and runoff
from treated areas may be hazardous to aquatic organisms in
neighboring areas. do not contaminate water by cleaning of
equipment or disposal of wastes."
- Products with Terrestrial Use(s): Under the Environmental
Hazard Statement, add the following precaution:
- "This pesticide is toxic to fish. Do not apply directly to
water or wetlands (swamps, bogs, marshes, and potholes).
Drift and runoff from treated areas may be hazardous to
aquatic organisms in neighboring areas. Do not contaminate
water by cleaning of equipment or disposal of wastes.
- Reentry Statement (For all products with crop uses):
- "Do not allow worker reentry into treated fields within 3 days
of application, for strawberries, and within 7 days, for all
other agricultural uses of propargite, unless appropriate
protective clothing is worn. Protective clothing means at
least a hat or other suitable head covering, a long-sleeved
shirt and long-legged trousers or a coverall-type garment
(closely woven fabric covering the body, including the arms
and legs), chemical-resistant gloves, socks, and shoes."
- Crop Rotation Statement:
- "Do not plant any food or feed crop in rotation within 6 months
after last application of propargite unless the crop is a
registered use for propargite."
- Irrigated Crops Statement:
- "Do not use water leaving propargite treated fields to
irrigate crops used for food or feed that are not registered
for use with propargite."
- Protective Clothing Statement:
- "Mixer/loaders must wear goggles or a face shield, chemical-
resistant apron, long-sleeve shirt, long pants, and mid-
forearm to elbow length chemical-resistant gloves.
Applicators must wear a long-sleeve shirt and long pants, and
chemical-resistant gloves while applying this pesticide.
Applicators must also wear a wide brimmed hat during upward
- Any article of clothing worn while applying product must be
cleaned before re-use. Clothing should be laundered
separately from household articles. Clothing that has been
drenched or has otherwise absorbed concentrated pesticide must
be disposed of in a sanitary landfill, incinerated, or burned
if allowed by State and local authorities."
- Endangered Species Statement (For Products with Use on
Terrestrial and Aquatic Food Crops, by February 1988)
- "The use of any pesticide in a manner that may kill or
otherwise harm an endangered or threatened species or
adversely modify their habitat is a violation of Federal laws.
The use of this product is controlled to prevent death or harm
to endangered or threatened species that occur in the
following counties or elsewhere in their range.
- Before using this pesticide in the following counties, you
must obtain the EPA Cropland Endangered Species Bulletin. The
use of this pesticide is prohibited in these counties unless
specified otherwise in the Bulletin. The EPA Bulletin is
available from either your local pesticide distributor, your
County Agricultural Extension Agent, the Endangered Species
Specialist in your State Wildlife Agency Headquarters, or the
appropriate Regional Office of the U.S. Fish and Wildlife
Service (FWS). THIS BULLETIN MUST BE REVIEWED PRIOR TO
5. SUMMARY OF MAJOR DATA GAPS
- The following list presents data required and the due date for
submission of this data:
Product Chemistry Due Dates
Product Chemistry Feb. 1987
Plant/Livestock Metabolism Feb. 1988
Plant/Animal Residues Feb. 1988
Storage Stability Feb. 1988
Sensitization Study July 1987
Subchronic Dermal Toxicity (21 days) May 1987
Subchronic Inhalation Toxicity (90 days) May 1987
Metabolism Sep. 1988
Mutagenicity Sep. 1987
Chronic Feeding/oncogenicity Dec. 1990
Two-Gen. Reproduction Dec. 1989
Soil Dissipation (Field Dec. 1988
Aquatic (Sediment) Dec. 1988
Rotational Crops (Confined) Dec. 1989
Rotational Crops (Field) Nov. 1990
Irrigated Crops Dec. 1989
Fish (Accumulation Studies) Sep. 1987
Hydrolysis Photodegradation July 1987
Aerobic Soil Metabolism Dec. 1988
Anaerobic Soil Metabolism Dec. 1988
Anaerobic Aquatic Dec. 1988
Aerobic Aquatic Dec. 1988
Leaching and Adsorption/Desorption July 1987
Volatility (Lab) July 1987
Foliar dissipation (Reentry) Nov. 1987
Soil Dissipation (Reentry) Nov. 1987
Glove Permeability Nov. 1987
Residue Level Monitoring (Aquatic) Feb. 1988
Avian Reproduction Sep. 1988
Freshwater Fish (Warmwater) July 1987
Freshwater Fish (Coldwater) July 1987
Acute LC50 Freshwater (Invertebrates) July 1987
Acute LC50 Estuarine & Marine
Organisms (Shrimps) July 1987
(Fish) July 1987
(Molusk) July 1987
6. CONTACT PERSON AT EPA
George T. LaRocca
Product Manager Number 15
U.S. Environmental Protection Agency
401 M Street. S.W.
Washington, D.C. 20460
DISCLAIMER: THE INFORMATION PRESENTED IN THIS CHEMICAL INFORMATION FACT
SHEET IS FOR INFORMATIONAL PURPOSES ONLY AND NOT TO BE USED TO FULFILL
DATA REQUIREMENTS FOR PESTICIDE REGISTRATION AND REREGISTRATION.