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propargite (Omite, Comite) Chemical Fact Sheet 9/86

                        CHEMICAL FACT SHEET FOR:
                                PROPARGITE

FACT SHEET NUMBER: 99

DATE ISSUED: SEPTEMBER 30, 1986


                     1.  DESCRIPTION OF CHEMICAL

- Generic Name:  2-(p-tert-butylphenoxy)cyclohexyl 2-propynyl sulfite
- Common Name:  Propargite
- Trade Names:  OmiteTM, ComiteTM, and Uniroyal D014
- EPA Shaughnessy Code:  097601
- Pesticide Type:  Acaricide
- Year of Initial Registration:  1966
- Chemical Family:  Organosulfite
- U.S. Producer:  Uniroyal Chemical Company


                 2.  USE PATTERNS AND FORMULATION

- Application Sites:  Terrestrial food crops (field, vegetable, aquatic
  food crop (cranberry); and greenhouse nonfood crops (ornamentals).
- Types of Formulations:  Single active ingredient (a.i.) formulations
  consist of 4% dust; 3% and 30% wettable powders; 5, 6 and 6.55
  pounds per gallon emulsifiable concentrate.  The technical formulation
  u is 85%a.i., and the formulation intermediate is 25% a.i.
- Types and Methods of Application:  End-use product is applied foliarly
  using air and/or ground equipment (including air blast).
- Application Rates:  Application rate ranges from 0.75 to 6.75 lb
  active ingredient per acre.
- Usual Carrier:  Water


                    3.  SCIENCE FINDINGS

Chemical Characteristics

- Physical State:  Viscous liquid
- Color:  Dark Amber
- Odor:  Faint solvent odor to very faint solvent odor.
- Density:  Specific gravity = 1.085 - 1.115 at 25 C; Bulk density =
  40.92 lb/ft.
- Solubility:  In water, about 0.5 ppm at 25 C., miscible with organic
  solvents such as acetone, benzene, and ethanol.
- Stability:  No evidence of breakdown in one year.
- Flash Point:  At least 38.5 degrees C.


Toxicological Characteristics

- Acute effects
  - Adequate data are not available to fully assess the toxicity of
    Propargite.  While, in general, propargite is not highly toxic
    (Category III oral, dermal and inhalation), it is in toxicity
    Category I for primary eye and skin irritation.  Available data
    present only supplementary information (as set fourth below), and
    additional data must be submitted.
  - Acute Oral Toxicity (Rat): 2.2 g/kg
  - Acute Dermal Toxicity (Rabbit):  3.16(1.63-6.15) ml/kg
  - Acute Inhalation:  > 2.5 mg/l
  - Primary Eye Irritation:  Corneal effects that were not reversible
    after 14 days were observed in four of six rabbits.
  - Dermal Sensitization:  Inconclusive
  - Subchronic Dermal Toxicity:  Inconclusive
- Chronic Effects
  - Teratogenicity (Rabbit):  Maternal NOEL = 2 mg/kg/day.  Maternal
    LEL s 6 mg/kg/day (reduced body weight gain).  Developmental
    Toxicity NOEL = 2 mg/kg/day; developmental (increased resorption,
    reduced body weight, and delayed ossification).  A/D ratio =
    maternal LEL/Developmental = 2/2 = 1.
  - 3-Gen. Reproduction (Rat):  Noel > 300 ppm.  Additional
    data is required.  Only one dose used throughout the study.
  - Mutagenicity:  Inconclusive.  Additional categories of
    mutagenicity testing are required.
  - Chronic Feeding/Oncogenicity (Dog):  NOEL = 900 ppm (HDT).  No
    adverse effects were observed by the hematology, blood chemistry
    determinations or urine examinations.
  - Feeding/Oncogenicity:  Inconclusive.  The study is classified as
    Supplementary because too few animals were examined histologically
    at 900 and 2000 ppm.  This study needs to be repeated.
  - Metabolism:  Inconclusive.  Additional data is required.
- Other Toxicological Effects
  - Propargite is not an organophosphate chemical; therefore, it does
    not have a neurotoxic potential, and a neurotoxicity study is not
    required.
- Major Routes of Exposure
  - There is a potential for dermal, ocular and inhalation exposure
    from mixing concentrates and applying spray mixtures.


Physiological and biochemical behavior characteristics

- Foliar Absorption:  Data are not available to evaluate the effects
  of propargite in plants.
- Translocation:  Data are not available to evaluate the translocation
  in plants.
- Mechanism of Pesticidal Actions:  Mode of activity involves residual
  killing action.


Environmental Characteristics

- Available data are insufficient to fully assess the environmental
  fate of propargite.  From the data that exists, however, there seems
  to be no reason for concern about the leaching of the parent
  chemical into groundwater.


Ecological Characteristics

- Avian Oral Toxicity:  Mallard duck - > 4640 ppm.
- Avian Dietary Toxicity:  Bobwhite quail - 3401 ppm;
                           Mallard duck - > 4640 ppm.
- Avian Reproduction:  Data are inconclusive to determine the effects
  on avian reproduction.  Additional data are required.
- Freshwater Fish Toxicity:  Bluegill Sunfish - 0.167 ppm;
                             Rainbow trout - 0.118 ppm.
- Aquatic Invertebrates (freshwater):  Daphnia magna - 0.092 ppm.
- Aquatic Invertebrates (lifecycle):  Daphia magna - 0.009 - 0.014 ppm.
- Available data indicate that propargite is practically nontoxic to
  avian species.  Propargite is highly toxic to fish.


Tolerance Assessment

- Tolerances have been established for residues of propargite in raw
  agricultural commodities, milk, eggs, meat, fat and meat by-products
  (40 CFR 180.259).

 Commodity                         Parts Per Million (ppm)
  Almonds                                    0.1
  Almonds, hulls                            55.0
  Apples                                     3.0
  Apricots                                   7.0
  Beans, dry                                 0.2
  Beans, succulent                          20.0
  Cattle, fat                                0.1
  Cattle, MBYP                               0.1
  Cattle, meat                               0.1
  Corn, fodder                              10.0
  Corn, forage                              10.0
  Corn, fresh (incl. sweet) (K+CWHR)         0.1
  Corn, grain                                0.1
  Cottonseed                                 0.1
  Cranberries                               10.1
  Eggs                                       o 1
  Figs (fresh)                               3.0
  Goats, fats                                0.1
  Goats, meat                                0.1
  Grapefruit                                 6.0
  Grapes                                    10.0
  Hogs, fat                                  0.1
  Hogs, meat                                 0.1
  Horses, fat                                0.1
  Horses, MBYP                               0.1
  Horses, meat                               0.1
  Lemons                                     5 0
  Milkfat (0.08 in whole milk)               2.0
  Mint                                       2.0
  Nectarines                                 4.0
  Oranges                                    5.0
  Peaches                                    7 0
  Peanuts                                    0.1
  Peanuts, forage                           10.0
  Peanuts, hay                              10.0
  Peanuts, hulls                            10.0
  Pears                                      3.0
  Plums (fresh prunes)                       7.0
  Potatoes                                   0.1
  Poultry, fat                               0.1
  Poultry, MBYP                              0.1
  Poultry, meat                              0.1
  Sheep, fat                                 0.1
  Sheep, MBYP                                0.1
  Sheep, meat                                0.1
  Sorghum, fodder                           10.0
  Sorghum, forage                           10.0
  Strawberries                               7.0
  Tea (dry)                                 10.0
  Walnuts                                    0.1

- Results of the Tolerance Assessment:  Because chronic feeding/
  oncogenicity and reproduction studies are needed, the current PADI is
  set on a 2-year dog feeding study a systemic NOEL at the highest dose
  tested (900 ppm).  At the highest dose tested, there were no effects
  observed.  With a safety factor of 1000, the TMRC is currently 112% of
  the PADI.  The TMRC, however, is based on the assumption that 100% of
  the crop for which a tolerance is established is treated with
  propargite, which is not the case.  If the TMRC is adjusted to reflect
  the actual percentage of crop treated, the TMRC would be reduced to a 
  percentage level of the PADI significantly lower than 112%.
  Therefore, the public should be in no danger from dietary exposure
  while the Agency awaits data.


Problems Known to Have Occurred with Use of the Chemical

- N/A


Summary Science Statement

- Propargite is not considered at this time to be oncogenic. Propargite
  has a low acute (Category III) oral, dermal, inhalation toxicity.  It
  is in toxicity category I however, for primary eye and primary skin
  irritation, and cases of severe dermatitis afflicting workers
  reentering treated sites have been reported.  Chronic testing reveals
  that propargite appears to have little effect on laboratory animals
  except at higher dosage levels; effects reported include depressed
  body weights and rates of weight gain.  Oral subchronic test results
  appear to parallel those for chronic testing.  Propargite is not
  teratogenic in rabbits and rats. Insufficient data exist to fully
  assess the dermal sensitization, subchronic dermal toxicity,
  subchronic inhalation toxicity, and mutagenicity of propargite.
  Additional metabolism testing is also necessary.  Propargite is
  relatively nontoxic to honey bees and avian species.  It is very
  highly toxic to freshwater fish.  The actual threat to aquatic
  organisms at this time cannot be accurately assessed due to the
  insufficiency of environmental fate data.  Field monitoring data to
  determine propargite residues in water from terrestrial applications
  is needed as is additional testing to determine the effects of end-use
  products on coldwater and warmwater species of fish, aquatic
  invertebrates, and estuarine and marine organisms.  The metabolism of
  propargite in both plants and animals is not sufficiently understood;
  additional metabolism data are necessary.  Storage stability data are
  also necessary, as well as additional crop residue data and processing
  studies for certain crops registered for propargite use.


          4. SUMMARY OF REGULATORY POSITIONS AND RATIONALES

- The following are warning statements that must be included on
  propargite pesticide labels.

  - Manufacturing Use Products

    - Under the Environmental Hazard Statement, add the following
      precaution.

      - "This pesticide is toxic to fish.  Do not discharge effluent
         containing this product into lakes, streams, ponds, estuaries,
         oceans, or public water unless this product is specifically
         identified and addressed in an NPDES permit.  Do not discharge
         effluent containing this product into sewer systems without
         previously notifying the sewage treatment plant authority.
         for guidance, contact your State Water Board or Regional
         Office of the EPA."

    - Protective Clothing Statement

      - "Mixer/loaders must wear goggles or a face shield, chemical-
         resistant apron, long-sleeved shirt and long pants or
         coveralls, and mid-forearm to elbow length chemical-resistant
         gloves when mixing, loading, or otherwise handling the
         concentrate."

  - End-Use Products

    - Products with Aquatic Use(s):  Under the Environmental Hazard
      Statement, add the following precaution:

      - "This pesticide is toxic to fish.  Do not apply directly to
         water except as specified on this label.  Drift and runoff
         from treated areas may be hazardous to aquatic organisms in
         neighboring areas.  do not contaminate water by cleaning of
         equipment or disposal of wastes."

    - Products with Terrestrial Use(s):  Under the Environmental
      Hazard Statement, add the following precaution:

      - "This pesticide is toxic to fish.  Do not apply directly to
         water or wetlands (swamps, bogs, marshes, and potholes).
         Drift and runoff from treated areas may be hazardous to
         aquatic organisms in neighboring areas.  Do not contaminate
         water by cleaning of equipment or disposal of wastes.

    - Reentry Statement (For all products with crop uses):

      - "Do not allow worker reentry into treated fields within 3 days
         of application, for strawberries, and within 7 days, for all
         other agricultural uses of propargite, unless appropriate
         protective clothing is worn.  Protective clothing means at
         least a hat or other suitable head covering, a long-sleeved
         shirt and long-legged trousers or a coverall-type garment
         (closely woven fabric covering the body, including the arms
         and legs), chemical-resistant gloves, socks, and shoes."

    - Crop Rotation Statement:

      - "Do not plant any food or feed crop in rotation within 6 months
         after last application of propargite unless the crop is a
         registered use for propargite."

    - Irrigated Crops Statement:

      - "Do not use water leaving propargite treated fields to
         irrigate crops used for food or feed that are not registered
         for use with propargite."

    - Protective Clothing Statement:

      - "Mixer/loaders must wear goggles or a face shield, chemical-
         resistant apron, long-sleeve shirt, long pants, and mid-
         forearm to elbow length chemical-resistant gloves.
         Applicators must wear a long-sleeve shirt and long pants, and
         chemical-resistant gloves while applying this pesticide.
         Applicators must also wear a wide brimmed hat during upward
         directed spray.
       - Any article of clothing worn while applying product must be
         cleaned before re-use.  Clothing should be laundered
         separately from household articles.  Clothing that has been
         drenched or has otherwise absorbed concentrated pesticide must
         be disposed of in a sanitary landfill, incinerated, or burned
         if allowed by State and local authorities."

    - Endangered Species Statement (For Products with Use on
      Terrestrial and Aquatic Food Crops, by February 1988)

      - "The use of any pesticide in a manner that may kill or
         otherwise harm an endangered or threatened species or
         adversely modify their habitat is a violation of Federal laws.
         The use of this product is controlled to prevent death or harm
         to endangered or threatened species that occur in the
         following counties or elsewhere in their range.
       - Before using this pesticide in the following counties, you
         must obtain the EPA Cropland Endangered Species Bulletin.  The
         use of this pesticide is prohibited in these counties unless
         specified otherwise in the Bulletin.  The EPA Bulletin is
         available from either your local pesticide distributor, your
         County Agricultural Extension Agent, the Endangered Species
         Specialist in your State Wildlife Agency Headquarters, or the
         appropriate Regional Office of the U.S. Fish and Wildlife
         Service (FWS).  THIS BULLETIN MUST BE REVIEWED PRIOR TO
         PESTICIDE USE."


                    5.  SUMMARY OF MAJOR DATA GAPS

- The following list presents data required and the due date for
  submission of this data:

 Product Chemistry                                Due Dates
 _________________                                __________

 Product Chemistry                                Feb. 1987

 Residue Chemistry
   Plant/Livestock Metabolism                     Feb. 1988
   Plant/Animal Residues                          Feb. 1988
   Storage Stability                              Feb. 1988

 Toxicology

   Sensitization Study                            July 1987
   Subchronic Dermal Toxicity (21 days)           May 1987
   Subchronic Inhalation Toxicity (90 days)       May 1987
   Metabolism                                     Sep. 1988
   Mutagenicity                                   Sep. 1987
   Chronic Feeding/oncogenicity                   Dec. 1990
   Two-Gen. Reproduction                          Dec. 1989

 Environmental Fate

   Soil Dissipation (Field                        Dec. 1988
   Aquatic (Sediment)                             Dec. 1988
   Rotational Crops (Confined)                    Dec. 1989
   Rotational Crops (Field)                       Nov. 1990
   Irrigated Crops                                Dec. 1989
   Fish (Accumulation Studies)                    Sep. 1987
   Hydrolysis Photodegradation                    July 1987
   Aerobic Soil Metabolism                        Dec. 1988
   Anaerobic Soil Metabolism                      Dec. 1988
   Anaerobic Aquatic                              Dec. 1988
   Aerobic Aquatic                                Dec. 1988
   Leaching and Adsorption/Desorption             July 1987
   Volatility (Lab)                               July 1987
   Foliar dissipation (Reentry)                   Nov. 1987
   Soil Dissipation (Reentry)                     Nov. 1987
   Glove Permeability                             Nov. 1987

 Ecological Effects

   Residue Level Monitoring (Aquatic)             Feb. 1988
   Avian Reproduction                             Sep. 1988
   Freshwater Fish (Warmwater)                    July 1987

   Freshwater Fish (Coldwater)                    July 1987
   Acute LC50 Freshwater (Invertebrates)          July 1987
   Acute LC50 Estuarine & Marine
     Organisms (Shrimps)                          July 1987
               (Fish)                             July 1987
               (Molusk)                           July 1987


                 6.  CONTACT PERSON AT EPA

George T. LaRocca
Product Manager Number 15
U.S. Environmental Protection Agency
TX-767C
401 M Street. S.W.
Washington, D.C. 20460
(703) 557-2400


DISCLAIMER:  THE INFORMATION PRESENTED IN THIS CHEMICAL INFORMATION FACT 
SHEET IS FOR INFORMATIONAL PURPOSES ONLY AND NOT TO BE USED TO FULFILL
DATA REQUIREMENTS FOR PESTICIDE REGISTRATION AND REREGISTRATION.