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Propoxur - Chemical Profile 3/85

                                      propoxur

      CHEMICAL NAME:      2-(1-methylethoxy) phenol methylcarbamate (56)

      DEC INGRED. CODE:

      TRADE NAME(S):      Baygon (56)

      FORMULATION(S):     Emulsifiable concentrate, wettable powder, bait,
                          and dust (56).

      TYPE:               Carbamate insecticide

      BASIC PRODUCER(S):  Mobay Chemical Corp.
                          Agricultural Chemicals Div.
                          P.O. Box 4913
                          Kansas City, MO 64120

      STATUS:             General use

      PRINCIPAL USES:  Particularly effective against insects affecting
      man and animals such as cockroaches, flies, and mosquitoes where rapid
      knockdown and residual properties are important.  Also effective for
      control of lawn and turf insects (56).

                                   I.  EFFICACY

           Housefly:  LD50 = 25 ug/g
           Western corn rootworm:  LD50 = 10 ug/g (10).

      Important Pests Controlled:  Earwigs, crickets, chinch bugs, cockroaches,
      ants, grasshoppers, aphids, leafhoppers, flies, fleas, thrips, mites,
      mosquitoes, spiders, ticks and many others (8a).

           Very effective against most public health pests.  Fast knockdown
      with long residual activity.  This compound has shown systemic activity
      when applied to the soil (8a).

                             II.  PHYSICAL PROPERTIES

      MOLECULAR FORMULA:  C11 H15 NO3 (62)

      MOLECULAR WEIGHT:   209.2 (62)

      PHYSICAL STATE:     Colorless crystalline solid (pure compound) (62)
                          Technical purity: minimum 95% (56)

      ODOR:               Faint characteristic odor (pure compound) (62)

      MELTING POINT:      84-87 C (pure compound) (62)

      VAPOR PRESSURE:     1.3 Pa at 120 C (pure compound) (62)

      SOLUBILITY:         2 g/l water at 20 C (pure compound) (62)

                          III.  HEALTH HAZARD INFORMATION

      OSHA STANDARD:  None established

      NIOSH RECOMMENDED LIMIT:  None established

      ACGIH RECOMMENDED LIMIT:  TWA (Time Weighted Average) = 0.5 mg/m3;
                                STEL (Short Term Exposure Limit) = 2 mg/m3
                                (15c).

      TOXICOLOGY

           A.  ACUTE TOXICITY

               DERMAL:  LD50 = 800-1000 mg/kg (male rat) (62)
                        LD50 = >500 mg/kg (male rabbit, technical); >5000
                          mg/kg (male rat, technical) (56).

               ORAL:    LD50 = 100-200 mg/kg (male rat, technical); 70-130
                          mg/kg (female rat, technical) (56).
                        LD50 = 90-128 mg/kg (rat); 100-109 mg/kg (male
                          mouse); 40 mg/kg (male guinea-pig) (62).

               INHALATION:  LC50 = 210 ug/l (female rat) (5a)

           B.  SUBACUTE AND CHRONIC TOXICITY:

           In 2-yr feeding trials male and female rats receiving 250 mg
      a.i./kg diet showed no ill effect; at 750 mg/kg diet the liver weight of
      female rats increased, otherwise there was no ill-effect (62).

                        IV.  ENVIRONMENTAL  CONSIDERATIONS

           Some hazard to birds, fish, and beneficial insects.  Hazardous to
      honey bees.  Biological magnification unlikely.  Some injury reported
      on chrysanthemums, carnations and hydrangeas at higher rates (1).

           LD50 (acute oral) is:  for red-winged blackbirds, 2-6 mg/kg;
      for starlings, 15-20 mg/kg (62).

           Propoxur is highly toxic to honey bees (62).

           LD50 = >1.0 ug/insect for honey bee.  LC50 = 0.029 ppm for
      Daphnia; 0.354 ppm for mosquito larvae (10).

      Species              LD50 (mg/kg)
      _______              ____________

      Mallard                   12
      Pheasant                  20
      Pigeon                    60
      House sparrow             13     (Ref. 10)

      Approximate Residual Period:  Up to 1 month on plant surfaces; several
      months on unexposed surfaces.  Breakdown in soil and water accelerated
      by alkalinity (1).

           Birds feeding on treated areas may be killed.  Toxic to fish.  Do
      not apply to tidal marshes or estuaries (8a).

                      V.  EMERGENCY AND FIRST AID PROCEDURES

           The chemical information provided below has been condensed
      from original source documents, primarily from "Recognition and
      Management of Pesticide Poisonings", 3rd ed. by Donald P.  Morgan,
      which have been footnoted.  This information has been provided in
      this form for your convenience and general guidance only.  In
      specific cases, further consultation and reference may be required
      and is recommended.  This information is not intended as a sub-
      stitute for a more exhaustive review of the literature nor for the
      judgement of a physician or other trained professional.

           If poisoning is suspected, do not wait for symptoms to develop.
      Contact a physician, the nearest hospital, or the nearest Poison
      Control Center.

      FREQUENT SYMPTOMS AND SIGNS OF POISONING BY CARBAMATE PESTICIDES

           DIARRHEA, NAUSEA, VOMITING, ABDOMINAL PAIN, PROFUSE SWEATING,
      SALIVATION, and BLURRED VISION are frequently reported.  Other common
      symptoms have been dyspnea, tremor, muscle twitching, ataxia, and
      headache.  Temporary paralysis of the extremities has also occurred.
      Most reported illnesses have not exceeded a few hours, and the
      prognosis is generally better than in orgnophosphate intoxications.
      However, in severe poisonings, one should anticipate the possibility of
      RESPIRATORY DEPRESSION, pulmonary edema, and convulsions.  Continuing
      absorption of intermediate quantities may cause protracted MALAISE,
      weakness, and anorexia, resembling influenza (25).

           SKIN CONTACT:  Bathe and shampoo victim with soap and water if
      there is any chance that skin and hair are contaminated (25).

           INGESTION:  If victim is alert and respiration is not
      depressed, give Syrup of Ipecac, followed by 1-2 glasses of water to
      induce vomiting; adults (including children over 12), 30 ml; children,
      15 ml (25).

           EYE CONTACT:  Wash with flowing water for at least 15 minutes (5a).

      NOTES TO PHYSICIAN:

      Administer ATROPINE SULFATE intravenously, or intramuscularly if IV
      injection is not possible.
      In MODERATELY SEVERE poisoning:  Adult dosage: 0.4-2.0 mg repeated
      every 15 minutes until atropinization is achieved (tachycardia,
      flushing, dry mouth, mydriasis).  Maintain atropinization by repeated
      doses for 2-12 hours, or longer, depending on severity of poisoning.
      Dosage for children under 12 years:  0.05 mg/kg body weight repeated
      every 15 minutes until atropinization is achieved.  Maintain
      atropinization with repeated dosage of 0.02-0.05 mg/kg.
      SEVERELY POISONED individuals may exhibit remarkable tolerance to
      atropine; twice the doses suggested above may be needed.
      Pralidoxime (Protopam (TM)-Ayerst, 2-PAM) is of doubtful value in
      poisonings by carbamate inhibitors of cholinesterase.  Atropine alone
      is almost always an adequate antidote (25).

                        VI.  FIRE AND EXPLOSION INFORMATION

           To be developed.

                                VII.  COMPATIBILITY

           Generally compatible with other insecticides and fungicides but
      broken down by alkaline materials (1).

                            VIII.  PROTECTIVE MEASURES

      STORAGE AND HANDLING:  Store in dry conditions at ambient or lower
      temperatures (56).

                       IX.  PROCEDURES FOR SPILLS AND LEAKS

                     IN CASE OF EMERGENCY, CALL, DAY OR NIGHT
                                  (800) 424-9300
                      PESTICIDE TEAM SAFETY NETWORK/CHEMTREC

                               X.  LITERATURE CITED

       1.  Harding, W.C.  1979.  Pesticide profiles, part one: insecticides
               and miticides.  Univ. Maryland, Coop. Ext. Serv. Bull. 267.
               30 pp.

       5a. Chemagro Corporation.  1971.  Baygon insecticide.  Kansas City,
               MO.

       8a. Thomson, W. T.  1976.  Agricultural chemicals - book 1:
               insecticides, acaricides, and ovicides.  Revised ed.  Thomson
               Publ., Indianapolis, IN.  232 pp.

      10.  Kuhr, R. J. and H. W. Dorough.  1976.  Carbamate insecticides:
               chemistry, biochemistry, and toxicology.  CRC Press, Inc.,
               Cleveland, OH.  301 pp.

      15c. American Conference of Governmental Industrial Hygienists.  1984.
               TLVs:  threshold limit values for chemical substances and
               physical agents in the work environment and biological exposure
               indices with intended changes for 1984-85.  Cincinnati, OH.
               116 pp.

      25.  Morgan, D.P.  1982.  Recognition and management of pesticide
               poisonings, 3rd ed.  U.S. Environmental Protection Agency,
               Washington, DC.  120 pp.

      56.  Farm Chemicals Handbook, 70th ed.  1984.  R. T. Meister, G. L.
               Berg, C. Sine, S. Meister, and J. Poplyk, eds.  Meister
               Publishing Co., Willoughby, OH.

      62.  The Pesticide Manual:  A World Compendium, 7th ed.  1983.  C.R.
               Worthing, ed.  The British Crop Protection Council, Croydon,
               England.  695 pp.

      3/29/85