resmethrin (SBP-1382) Chemical Profile 4/85
CHEMICAL NAME: ([5-(phenylmethyl)-3-furanyl] methyl 2,2-dimethyl-3-
(2-methyl-1-propenyl) cyclopropanecarboxylate (56)
DEC INGRED. CODE:
TRADE NAME(S): Premgard, Pyretherm, Synthrin (56)
FORMULATION(S): Aerosols, aqueous pressurized sprays, emulsifiable
concentrates, transparent emulsions, and oil-base liquids including ULV
TYPE: Synthetic pyrethroid insecticide
BASIC PRODUCER(S): Fairfield American Corp.
An AOSI Co.
238 Wilson Ave.
Newark, NJ 07105
P.O. Box 89
Buckner, KY 40010
STATUS: General use
PRINCIPAL USES: Flying and crawling insect control for household,
greenhouse, indoor landscaping, mushroom houses, industrial, stored
product insects, and mosquito insect control. Cleared for use in
aerosols, aqueous pressurized sprays, emulsifiable concentrates,
transparent emulsions, and oil base liquids including ULV. Cleared for
fabric protection, pet sprays, pet shampoo, and application on horses and
in horse stables. Cleared for USDA meat and poultry inspection programs
Important Pests Controlled: Flies, roaches, ants, mosquitoes, wasps,
gnats, spiders, centipedes, fleas, earwigs, sowbugs, moths and others
Synergists used with pyrethrins do not work well with this material.
Replaces the pyrethrins at the same concentration without a synergist. A
contact insecticide with fast knockdown (8a).
II. PHYSICAL PROPERTIES
MOLECULAR FORMULA: C22 H26 O3 (62)
MOLECULAR WEIGHT: 338.4 (62)
PHYSICAL STATE: Colorless waxy solid (technical grade, containing
20-30% of (1RS)-cis- and 80-70% of (1RS)-trans-
ODOR: Characteristic chrysanthemate odor (56)
MELTING POINT: 43-48 C (technical grade) (62)
VAPOR PRESSURE: 1.46 uPa at 30 C (technical grade) (62)
SOLUBILITY: <1 mg/l water at 30 C (technical grade) (62)
III. HEALTH HAZARD INFORMATION
OSHA STANDARD: None established
NIOSH RECOMMENDED LIMIT: None established
ACGIH RECOMMENDED LIMIT: None established
A. ACUTE TOXICITY
DERMAL: LD50 = 2500 mg/kg (rabbit); skin sensitization
negative (guinea-pig) (56).
LD50 = >3000 mg/kg (rat) (62)
ORAL: LD50 = 4240 mg/kg (rat, technical material) (56)
LD50 = >2500 mg/kg (rat) (62)
INHALATION: No untoward effects at a space concentration of
100 mg/1 or 200 ppm (rats and dogs). Rats
exposed to daily intermittent sprays from a true
aerosol at a space concentration of 73 ppm for
five days resulted in no deaths or untoward
effects including prenatal toxicity (19).
EYES: Results of tests conducted in a number of laboratories
classified resmethrin as mildly irritating (rabbits)
B. SUBACUTE AND CHRONIC TOXICITY:
In 90-day feeding trials rats receiving 3000 mg/kg diet suffered no
ill-effect. No teratogenic effect was seen in rats receiving 25 mg/kg
daily, or in mice at 50 mg/kg daily (62).
No mutagenic activity was demonstrated in both active and nonactive
tests. No teratogenic response was observed (19).
IV. ENVIRONMENTAL CONSIDERATIONS
Little hazard to birds, fish, and beneficial insects. Hazardous to
honey bees. Biological magnification very unlikely. Nonphytotoxic
when used as directed (1).
Toxic to fish (8a).
Approximate Residual Period: Short lived; compound is readily
V. EMERGENCY AND FIRST AID PROCEDURES
The chemical information provided below has been condensed
from original source documents, primarily from "Recognition and
Management of Pesticide Poisonings", 3rd ed. by Donald P. Morgan,
which have been footnoted. This information has been provided in
this form for your convenience and general guidance only. In
specific cases, further consultation and reference may be required
| and is recommended. This information is not intended as a sub-
stitute for a more exhaustive review of the literature nor for the
judgement of a physician or other trained professional.
If poisoning is suspected, do not wait for symptoms to develop.
Contact a physician, the nearest hospital, or the nearest Poison
FREQUENT SYMPTOMS AND SIGNS OF UNDUE EXPOSURE TO PYRETHRUM, PYRETHRINS,
PYRETHROIDS, AND PIPERONYL BUTOXIDE.
A STUFFY, RUNNY NOSE and scratchy throat from inhalation of partly
purified pyrethrum extract is the most common adverse effect of these
agents. Asthmatic WHEEZING may be precipiated by exposure of
predisposed individuals. Sudden bronchospasm, swelling of oral and
laryngeal mucous membranes, and shock (anaphylaxis) have been reported
after pyrethrum inhalation. Delayed appearance of dyspnea, cough and
fever, with patchy lung infiltrates on x-ray, suggest hypersensitivity
pneumonitis. Nervous irritability, tremors, and ataxis have occurred
rarely in persons who have had massive inhalation exposure to
pyrethrins. Halocarbon propellents in bug-bomb products present a risk
of CARDIAC ARRHYTHMIA and possibly fibrillation if inhaled to excess.
Hydrocarbons used as solvents in spray products are likely to result in
COUGH, FEVER, and CHEST PAIN (hydrocarbon pneumonitis) if these liquids
are inadvertently aspirated (25).
SKIN CONTACT: Wash contaminated skin with soap and water (25).
INGESTION: Ingestion of a small amount is not likely to cause
poisoning. Examine the label to identify additional insecticides which
may be more toxic. Base treatment on the most toxic ingredients. For
ingestion of large amounts (>5 mg/kg) induce vomiting by giving Syrup
of Ipecac (25).
EYE CONTACT: Wash contaminating pesticide from the eye with copious
amounts of water (25).
NOTES TO PHYSICIAN:
If victim is not fully alert, empty stomach immediately by intubation,
aspiration, and lavage, using isotonic saline or 5% sodium
bicarbonate. Because many pesticides are dissolved in petroleum
distillates, emesis and intubation of the stomach involve a risk that
solvent will be aspirated, leading to chemical pneumonitis. Do not
administer or instill milk, cream, or other substances containing
vegetable or animal fats, which enhance absorption of lipophilic
substances, such as pyrethrins and pyrethroids.
Diazepam (Valium) 5-10 mg in adults, 0.1 mg/kg in children, given
orally or slowly IV, should control nervousness and tremors in rare
cases having these symptoms after extraordinary exposure to pyrethrins
and pyrethroids (25).
VI. FIRE AND EXPLOSION INFORMATION
To be developed.
Usually not combined with other materials (1).
VIII. PROTECTIVE MEASURES
STORAGE AND HANDLING: Avoid contact with skin. Toxic to fish. Keep out
of any body of water. Do not contaminate water by cleaning of equipment
or disposal of waste. Do not reuse empty container. Destroy it by
perforating or crushing. Bury or discard in a safe place away from water
IX. PROCEDURES FOR SPILLS AND LEAKS
IN CASE OF EMERGENCY, CALL, DAY OR NIGHT
PESTICIDE TEAM SAFETY NETWORK/CHEMTREC
X. LITERATURE CITED
1. Harding, W.C. 1979. Pesticide profiles, part one: insecticides
and miticides. Univ. Maryland, Coop. Ext. Serv. Bull. 267.
8a. Thomson, W. T. 1976. Agricultural chemicals - book 1:
insecticides, acaricides, and ovicides. Revised ed. Thomson
Publ., Indianapolis, IN. 232 pp.
19. Penick Corporation. Technical information sheet: Crossfire 3%
SBP-1382 (contains resmethrin) multipurpose spray. Lyndhurst,
25. Morgan, D.P. 1982. Recognition and management of pesticide
poisonings, 3rd ed. U.S. Environmental Protection Agency,
Washington, DC. 120 pp.
56. Farm Chemicals Handbook, 70th ed. 1984. R. T. Meister, G. L.
Berg, C. Sine, S. Meister, and J. Poplyk, eds. Meister
Publishing Co., Willoughby, OH.
62. The Pesticide Manual: A World Compendium, 7th ed. 1983. C.R.
Worthing, ed. The British Crop Protection Council, Croydon,
England. 695 pp.