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resmethrin (SBP-1382) Chemical Profile 4/85

                                     resmethrin

      CHEMICAL NAME:      ([5-(phenylmethyl)-3-furanyl] methyl 2,2-dimethyl-3-
                          (2-methyl-1-propenyl) cyclopropanecarboxylate (56)

      DEC INGRED. CODE:

      TRADE NAME(S):      Premgard, Pyretherm, Synthrin (56)

      FORMULATION(S):  Aerosols, aqueous pressurized sprays, emulsifiable
      concentrates, transparent emulsions, and oil-base liquids including ULV
      (56).

      TYPE:               Synthetic pyrethroid insecticide

      BASIC PRODUCER(S):  Fairfield American Corp.
                          An AOSI Co.
                          238 Wilson Ave.
                          Newark, NJ 07105

                          Rigo Co.
                          P.O. Box 89
                          Buckner, KY 40010

      STATUS:             General use

      PRINCIPAL USES:  Flying and crawling insect control for household,
      greenhouse, indoor landscaping, mushroom houses, industrial, stored
      product insects, and mosquito insect control.  Cleared for use in
      aerosols, aqueous pressurized sprays, emulsifiable concentrates,
      transparent emulsions, and oil base liquids including ULV.  Cleared for
      fabric protection, pet sprays, pet shampoo, and application on horses and
      in horse stables.  Cleared for USDA meat and poultry inspection programs
      (56).

                                I.  EFFICACY

      Important Pests Controlled:  Flies, roaches, ants, mosquitoes, wasps,
      gnats, spiders, centipedes, fleas, earwigs, sowbugs, moths and others
      (8a).
           Synergists used with pyrethrins do not work well with this material.
      Replaces the pyrethrins at the same concentration without a synergist.  A
      contact insecticide with fast knockdown (8a).


                          II.  PHYSICAL PROPERTIES

      MOLECULAR FORMULA: C22 H26 O3 (62)

      MOLECULAR WEIGHT:  338.4 (62)

      PHYSICAL STATE:    Colorless waxy solid (technical grade, containing
                         20-30% of (1RS)-cis- and 80-70% of (1RS)-trans-
                         isomers) (62).

      ODOR:              Characteristic chrysanthemate odor (56)

      MELTING POINT:     43-48 C (technical grade) (62)

      VAPOR PRESSURE:    1.46 uPa at 30 C (technical grade) (62)

      SOLUBILITY:        <1 mg/l water at 30 C (technical grade) (62)


                        III.  HEALTH HAZARD INFORMATION

      OSHA STANDARD:  None established

      NIOSH RECOMMENDED LIMIT:  None established

      ACGIH RECOMMENDED LIMIT:  None established

      TOXICOLOGY

           A.  ACUTE TOXICITY

               DERMAL:  LD50 = 2500 mg/kg (rabbit); skin sensitization
                          negative (guinea-pig) (56).
                        LD50 = >3000 mg/kg (rat) (62)

               ORAL:    LD50 = 4240 mg/kg (rat, technical material) (56)
                        LD50 = >2500 mg/kg (rat) (62)

               INHALATION:  No untoward effects at a space concentration of
                            100 mg/1 or 200 ppm (rats and dogs).  Rats
                            exposed to daily intermittent sprays from a true
                            aerosol at a space concentration of 73 ppm for
                            five days resulted in no deaths or untoward
                            effects including prenatal toxicity (19).

               EYES:    Results of tests conducted in a number of laboratories
                        classified resmethrin as mildly irritating (rabbits)
                        (19).

           B.  SUBACUTE AND CHRONIC TOXICITY:

           In 90-day feeding trials rats receiving 3000 mg/kg diet suffered no
      ill-effect.  No teratogenic effect was seen in rats receiving 25 mg/kg
      daily, or in mice at 50 mg/kg daily (62).
           No mutagenic activity was demonstrated in both active and nonactive
      tests.  No teratogenic response was observed (19).


                       IV.  ENVIRONMENTAL CONSIDERATIONS

           Little hazard to birds, fish, and beneficial insects.  Hazardous to
      honey bees.  Biological magnification very unlikely.  Nonphytotoxic
      when used as directed (1).
           Toxic to fish (8a).

      Approximate Residual Period:  Short lived; compound is readily
      biodegradable (1).


                   V.  EMERGENCY AND FIRST AID PROCEDURES

           The chemical information provided below has been condensed
      from original source documents, primarily from "Recognition and
      Management of Pesticide Poisonings", 3rd ed. by Donald P. Morgan,
      which have been footnoted.  This information has been provided in
      this form for your convenience and general guidance only.  In
      specific cases, further consultation and reference may be required
    |  and is recommended.  This information is not intended as a sub-
      stitute for a more exhaustive review of the literature nor for the
      judgement of a physician or other trained professional.

           If poisoning is suspected, do not wait for symptoms to develop.
      Contact a physician, the nearest hospital, or the nearest Poison
      Control Center.

      FREQUENT SYMPTOMS AND SIGNS OF UNDUE EXPOSURE TO PYRETHRUM, PYRETHRINS,
      PYRETHROIDS, AND PIPERONYL BUTOXIDE.

      A STUFFY, RUNNY NOSE and scratchy throat from inhalation of partly
      purified pyrethrum extract is the most common adverse effect of these
      agents.  Asthmatic WHEEZING may be precipiated by exposure of
      predisposed individuals.  Sudden bronchospasm, swelling of oral and
      laryngeal mucous membranes, and shock (anaphylaxis) have been reported
      after pyrethrum inhalation.  Delayed appearance of dyspnea, cough and
      fever, with patchy lung infiltrates on x-ray, suggest hypersensitivity
      pneumonitis.  Nervous irritability, tremors, and ataxis have occurred
      rarely in persons who have had massive inhalation exposure to
      pyrethrins.  Halocarbon propellents in bug-bomb products present a risk
      of CARDIAC ARRHYTHMIA and possibly fibrillation if inhaled to excess.
      Hydrocarbons used as solvents in spray products are likely to result in
      COUGH, FEVER, and CHEST PAIN (hydrocarbon pneumonitis) if these liquids
      are inadvertently aspirated (25).

           SKIN CONTACT:  Wash contaminated skin with soap and water (25).

           INGESTION:  Ingestion of a small amount is not likely to cause
      poisoning.  Examine the label to identify additional insecticides which
      may be more toxic.  Base treatment on the most toxic ingredients.  For
      ingestion of large amounts (>5 mg/kg) induce vomiting by giving Syrup
      of Ipecac (25).

           EYE CONTACT:  Wash contaminating pesticide from the eye with copious
      amounts of water (25).

      NOTES TO PHYSICIAN:

      If victim is not fully alert, empty stomach immediately by intubation,
      aspiration, and lavage, using isotonic saline or 5% sodium
      bicarbonate.  Because many pesticides are dissolved in petroleum
      distillates, emesis and intubation of the stomach involve a risk that
      solvent will be aspirated, leading to chemical pneumonitis.  Do not
      administer or instill milk, cream, or other substances containing
      vegetable or animal fats, which enhance absorption of lipophilic
      substances, such as pyrethrins and pyrethroids.
      Diazepam (Valium) 5-10 mg in adults, 0.1 mg/kg in children, given
      orally or slowly IV, should control nervousness and tremors in rare
      cases having these symptoms after extraordinary exposure to pyrethrins
      and pyrethroids (25).


                      VI.  FIRE AND EXPLOSION INFORMATION

           To be developed.


                             VII.  COMPATIBILITY

           Usually not combined with other materials (1).


                          VIII.  PROTECTIVE MEASURES

      STORAGE AND HANDLING:  Avoid contact with skin.  Toxic to fish. Keep out
      of any body of water.  Do not contaminate water by cleaning of equipment
      or disposal of waste.  Do not reuse empty container.  Destroy it by
      perforating or crushing.  Bury or discard in a safe place away from water
      supplies (56).


                     IX.  PROCEDURES FOR SPILLS AND LEAKS

                    IN CASE OF EMERGENCY, CALL, DAY OR NIGHT
                                 (800) 424-9300
                     PESTICIDE TEAM SAFETY NETWORK/CHEMTREC


                               X.  LITERATURE CITED

       1.  Harding, W.C.  1979.  Pesticide profiles, part one: insecticides
               and miticides.  Univ. Maryland, Coop. Ext. Serv. Bull. 267.
               30 pp.

       8a. Thomson, W. T.  1976.  Agricultural chemicals - book 1:
               insecticides, acaricides, and ovicides.  Revised ed.  Thomson
               Publ., Indianapolis, IN.  232 pp.

      19.  Penick Corporation.  Technical information sheet:  Crossfire 3%
               SBP-1382 (contains resmethrin) multipurpose spray.  Lyndhurst,
               NJ.

      25.  Morgan, D.P.  1982.  Recognition and management of pesticide
               poisonings, 3rd ed.  U.S. Environmental Protection Agency,
               Washington, DC.  120 pp.

      56.  Farm Chemicals Handbook, 70th ed.  1984.  R. T. Meister, G. L.
               Berg, C. Sine, S. Meister, and J. Poplyk, eds.  Meister
               Publishing Co., Willoughby, OH.

      62.  The Pesticide Manual:  A World Compendium, 7th ed.  1983.  C.R.
               Worthing, ed.  The British Crop Protection Council, Croydon,
               England.  695 pp.

      4/26/85