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TEPP (Kilmite 40) - Chemical Profile 3/85


      CHEMICAL NAME:      Tetraethyl diphosphate (56)

      TRADE NAME(S):      Kilmite-40, Tetron, Vapotone (56)

      FORMULATION(S):     Emulsifiable concentrate (1)

      TYPE:               Organophosphate insecticide-miticide

      BASIC PRODUCER(S):  Miller Chemical and Fertilizer Corp.
                          P.O. Box 333
                          Hanover, PA 17331

      STATUS:             Restricted use.  Product discontinued by Miller
                          Chemical and Fertilizer Corp (56).

      PRINCIPAL USES:     TEPP is a non-systemic acaricide and aphicide with a
                          very brief persistence (62).

                                   I.  EFFICACY

      Important Pests Controlled:  Aphids, mites, spiders, mealybugs,
      leafhoppers, lygus bugs, thrips, leafminers, and many others (8a).

                             II.  PHYSICAL PROPERTIES

      MOLECULAR FORMULA:  C8 H20 O7 P2 (62)

      MOLECULAR WEIGHT:   290.2 (62)

      PHYSICAL STATE:     Colorless hygroscopic liquid (pure compound);
                          dark amber-colored mobile liquid (technical
                          product) (62).

      BOILING POINT:      124 C/1 mmHg (pure compound) (62)

      VAPOR PRESSURE:     21 mPa at 20 C (pure compound) (62)

      SOLUBILITY:         Miscible with water (pure compound) (62)

                          III.  HEALTH HAZARD INFORMATION

      OSHA STANDARD:  0.05 mg/m3 averaged over an 8-hour work shift (14)

      NIOSH RECOMMENDED LIMIT:  None established

      ACGIH RECOMMENDED LIMIT:  TWA (Time Weighted Average) = 0.004 ppm, 0.05
                                mg/m3; STEL (Short Term Exposure Limit) = 0.01
                                ppm, 0.2 mg/m3 (deleted); skin notation (15c).


           A.  ACUTE TOXICITY

               DERMAL:  LD50 = 2.4 mg/kg (male rat) (62)

               ORAL:    LD50 = 1.12 mg/kg (rat) (62)


           To be developed.

                        IV.  ENVIRONMENTAL  CONSIDERATIONS

           Moderately hazardous to birds, fish, beneficial insects, and honey
      bees.  Biological magnification unlikely.  Check label for
      phytotoxicity (1).

           It is rapidly metabolised by animals (62).

           Hazardous to wildlife, highly toxic to bees (8a).

      Approximate Residual Period:  Hydrolyzes and breaks down rapidly
                                    (48 hrs.) (1).


           The chemical information provided below has been condensed
      from original source documents, primarily from "Recognition and
      Management of Pesticide Poisonings", 3rd ed. by Donald P.  Morgan,
      which have been footnoted.  This information has been provided in
      this form for your convenience and general guidance only.  In
      specific cases, further consultation and reference may be required
      and is recommended.  This information is not intended as a sub-
      stitute for a more exhaustive review of the literature nor for the
      judgement of a physician or other trained professional.

           If poisoning is suspected, do not wait for symptoms to develop.
      Contact a physician, the nearest hospital, or the nearest Poison
      Control Center.


           Symptoms of acute poisoning develop during exposure or within 12
      hours (usually within four hours) of contact.  headACHE, DIZZINESS,
      CRAMPS, DIARRHEA, and SWEATING are common early symptoms.  Blurred or

      dark vision, confusion, tightness in the chest, wheezing, productive
      cough, and PULMONARY EDEMA may occur.  Incontinence, unconsciousness
      and convulsions indicate very severe poisoning.  SLOW HEARTBEAT,
      salivation, and tearing are common.  TOXIC PSYCHOSIS, with manic or
      bizarre behavior, has led to misdiagnosis of acute alcoholism.  Slowing
      of the heartbeat may rarely progress to complete sinus arrest.
      RESPIRATORY DEPRESSION may be fatal.  Continuing daily absorption of
      organophosphate at intermediate dosage may cause an INFLUENZA-LIKE
      ILLNESS characterized by weakness, anorexia, and malaise (25).

           SKIN CONTACT:  Bathe and shampoo victim with soap and water if
      there is any chance that skin and hair are contaminated (25).

           INGESTION:  If victim is alert and respiration is not
      depressed, give Syrup of Ipecac, followed by 1-2 glasses of water to
      induce vomiting.  Adults (12 years and over):  30 ml; children:  15 ml

           INHALATION:  If a person breathes in large amounts of TEPP, move
      the exposed person to fresh air at once.  If breathing has stopped,
      perform artificial respiration.  Keep the affected person warm and at

      rest.  Get medical attention as soon as possible (14).

           EYE CONTACT:  Wash eyes immediately with large amounts of water,
      lifting the lower and upper lids occasionally.  Get medical attention
      immediately.  Contact lenses should not be worn when working with this
      chemical (14).


      Administer ATROPINE SULFATE intravenously, or intramuscularly, if IV
      injection is not possible.
      In MODERATELY SEVERE poisoning:  Adult dosage:  0.4-2.0 mg repeated
      every 15 minutes until atropinization is achieved:  tachycardia (pulse
      of 140 per minute), flushing, dry mouth, dilated pupils.  Maintain
      atropinization by repeated doses for 2-12 hours or longer depending on
      severity of poisoning.
      Dosage for children under 12 years:  0.05 mg/kg body weight, repeated
      every 15 minutes until atropinization is achieved.  Maintain
      atropinization with repeated dosage of 0.02-0.05 mg/kg.
      SEVERELY POISONED individuals may exhibit remarkable tolerance to
      atropine; two or more times the dosages suggested above may be needed.
      Administer PRALIDOXIME (Protopam (TM)-Ayerst, 2-PAM) in cases of severe
      poisoning in which respiratory depression, muscle weakness and
      twitchings are severe.
      Adult dosage:  1.0 gm intravenously at no more than 0.5 gm per minute.
      Child's dose (under 12 years):  20-50 mg/kg (depending on severity of
      poisoning) intravenously, injecting no more than half the total dose
      per minute.
      Dosage of pralidoxime may be repeated in 1-2 hours, then at 10-12 hour
      intervals if needed.  In very severe poisonings, dosage rates may be
      doubled (25).

                        VI.  FIRE AND EXPLOSION INFORMATION

           Temperatures above 150 C (300 F) cause decomposition with
      formation of flammable ethylene gas.  Contact with strong oxidizers may
      cause fires and explosions.  Toxic gases and vapors (such as phosphoric
      acid mist and carbon monoxide) may be released when TEPP decomposes

                                VII.  COMPATIBILITY

           Incompatible with alkaline materials and many pesticides (1).
      Corrosive to aluminum (8a).

                           VIII.  PROTECTIVE MEASURES

      PROTECTIVE CLOTHING:  Employees should be provided with and required
      to use impervious clothing, gloves, face shields (eight-inch minimum)
      and other appropriate protective clothing necessary to prevent any
      possibility of skin contact with TEPP (14).

      PROTECTIVE EQUIPMENT:  Respirators may be used when engineering and
      work practice controls are not technically feasible, when such controls
      are in the process of being installed, or when they fail and need to be
      supplemented.  The only respirators permitted are those that have been
      approved by the Mine Safety and Health Administration, or by the
      National Institute for Occupational Safety and Health (14).

                       IX.  PROCEDURES FOR SPILLS AND LEAKS

                                  (800) 424-9300

           Persons not wearing protective equipment and clothing should be
      restricted from areas of spills or leaks until cleanup has been

      If TEPP is spilled or leaked, the following steps should be taken:

      1.   Ventilate area of spill or leak.
      2.   Collect for reclamation or absorb in vermiculite, dry sand, earth,
           or a similar material.

      Waste disposal method:

           TEPP may be disposed of by absorbing in vermiculite, dry sand,
      earth, or a similar material and disposing in sealed containers in a
      secured sanitary landfill (14).

                               X.  LITERATURE CITED

       1.  Harding, W.C.  1979.  Pesticide profiles, part one: insecticides
               and miticides.  Univ. Maryland, Coop. Ext. Serv. Bull. 267.
               30 pp.

       8a. Thomson, W. T.  1976.  Agricultural chemicals - book 1:
               insecticides, acaricides, and ovicides.  Revised ed.  Thomson

               Publ., Indianapolis, IN.  232 pp.

      14.  U. S. Department of Health and Human Services, National Institute
               for Occuptational Safety and Health.  1981.  Occupational
               health guidelines for chemical hazards.  F. W. Mackinson, R.
               S. Stricoff, L. J. Partridge, Jr., and A. D. Little, Inc.,
               eds.  DHHS (NIOSH) Publ. No. 81-123.  Washington, DC.

      15c. American Conference of Governmental Industrial Hygienists.  1984.
               TLVs:  threshold limit values for chemical substances and
               physical agents in the work environment and biological exposure
               indices with intended changes for 1984-85.  Cincinnati, OH.
               116 pp.

      25.  Morgan, D.P.  1982.  Recognition and management of pesticide
               poisonings, 3rd ed.  U.S. Environmental Protection Agency,
               Washington, DC.  120 pp.

      56.  Farm Chemicals Handbook, 70th ed.  1984.  R. T. Meister, G. L.
               Berg, C. Sine, S. Meister, and J. Poplyk, eds.  Meister
               Publishing Co., Willoughby, OH.

      62.  The Pesticide Manual:  A World Compendium, 7th ed.  1983.  C.R.
               Worthing, ed.  The British Crop Protection Council, Croydon,
               England.  695 pp.