TEPP (Kilmite 40) - Chemical Profile 3/85
CHEMICAL NAME: Tetraethyl diphosphate (56)
TRADE NAME(S): Kilmite-40, Tetron, Vapotone (56)
FORMULATION(S): Emulsifiable concentrate (1)
TYPE: Organophosphate insecticide-miticide
BASIC PRODUCER(S): Miller Chemical and Fertilizer Corp.
P.O. Box 333
Hanover, PA 17331
STATUS: Restricted use. Product discontinued by Miller
Chemical and Fertilizer Corp (56).
PRINCIPAL USES: TEPP is a non-systemic acaricide and aphicide with a
very brief persistence (62).
Important Pests Controlled: Aphids, mites, spiders, mealybugs,
leafhoppers, lygus bugs, thrips, leafminers, and many others (8a).
II. PHYSICAL PROPERTIES
MOLECULAR FORMULA: C8 H20 O7 P2 (62)
MOLECULAR WEIGHT: 290.2 (62)
PHYSICAL STATE: Colorless hygroscopic liquid (pure compound);
dark amber-colored mobile liquid (technical
BOILING POINT: 124 C/1 mmHg (pure compound) (62)
VAPOR PRESSURE: 21 mPa at 20 C (pure compound) (62)
SOLUBILITY: Miscible with water (pure compound) (62)
III. HEALTH HAZARD INFORMATION
OSHA STANDARD: 0.05 mg/m3 averaged over an 8-hour work shift (14)
NIOSH RECOMMENDED LIMIT: None established
ACGIH RECOMMENDED LIMIT: TWA (Time Weighted Average) = 0.004 ppm, 0.05
mg/m3; STEL (Short Term Exposure Limit) = 0.01
ppm, 0.2 mg/m3 (deleted); skin notation (15c).
A. ACUTE TOXICITY
DERMAL: LD50 = 2.4 mg/kg (male rat) (62)
ORAL: LD50 = 1.12 mg/kg (rat) (62)
B. SUBACUTE AND CHRONIC TOXICITY:
To be developed.
IV. ENVIRONMENTAL CONSIDERATIONS
Moderately hazardous to birds, fish, beneficial insects, and honey
bees. Biological magnification unlikely. Check label for
It is rapidly metabolised by animals (62).
Hazardous to wildlife, highly toxic to bees (8a).
Approximate Residual Period: Hydrolyzes and breaks down rapidly
(48 hrs.) (1).
V. EMERGENCY AND FIRST AID PROCEDURES
The chemical information provided below has been condensed
from original source documents, primarily from "Recognition and
Management of Pesticide Poisonings", 3rd ed. by Donald P. Morgan,
which have been footnoted. This information has been provided in
this form for your convenience and general guidance only. In
specific cases, further consultation and reference may be required
and is recommended. This information is not intended as a sub-
stitute for a more exhaustive review of the literature nor for the
judgement of a physician or other trained professional.
If poisoning is suspected, do not wait for symptoms to develop.
Contact a physician, the nearest hospital, or the nearest Poison
FREQUENT SYMPTOMS AND SIGNS OF POISONING BY ORGANOPHOSPHATE PESTICIDES
Symptoms of acute poisoning develop during exposure or within 12
hours (usually within four hours) of contact. headACHE, DIZZINESS,
WEAKNESS, INCOORDINATION, MUSCLE TWITCHING, TREMOR, NAUSEA, ABDOMINAL
CRAMPS, DIARRHEA, and SWEATING are common early symptoms. Blurred or
dark vision, confusion, tightness in the chest, wheezing, productive
cough, and PULMONARY EDEMA may occur. Incontinence, unconsciousness
and convulsions indicate very severe poisoning. SLOW HEARTBEAT,
salivation, and tearing are common. TOXIC PSYCHOSIS, with manic or
bizarre behavior, has led to misdiagnosis of acute alcoholism. Slowing
of the heartbeat may rarely progress to complete sinus arrest.
RESPIRATORY DEPRESSION may be fatal. Continuing daily absorption of
organophosphate at intermediate dosage may cause an INFLUENZA-LIKE
ILLNESS characterized by weakness, anorexia, and malaise (25).
SKIN CONTACT: Bathe and shampoo victim with soap and water if
there is any chance that skin and hair are contaminated (25).
INGESTION: If victim is alert and respiration is not
depressed, give Syrup of Ipecac, followed by 1-2 glasses of water to
induce vomiting. Adults (12 years and over): 30 ml; children: 15 ml
INHALATION: If a person breathes in large amounts of TEPP, move
the exposed person to fresh air at once. If breathing has stopped,
perform artificial respiration. Keep the affected person warm and at
rest. Get medical attention as soon as possible (14).
EYE CONTACT: Wash eyes immediately with large amounts of water,
lifting the lower and upper lids occasionally. Get medical attention
immediately. Contact lenses should not be worn when working with this
NOTES TO PHYSICIAN:
Administer ATROPINE SULFATE intravenously, or intramuscularly, if IV
injection is not possible.
In MODERATELY SEVERE poisoning: Adult dosage: 0.4-2.0 mg repeated
every 15 minutes until atropinization is achieved: tachycardia (pulse
of 140 per minute), flushing, dry mouth, dilated pupils. Maintain
atropinization by repeated doses for 2-12 hours or longer depending on
severity of poisoning.
Dosage for children under 12 years: 0.05 mg/kg body weight, repeated
every 15 minutes until atropinization is achieved. Maintain
atropinization with repeated dosage of 0.02-0.05 mg/kg.
SEVERELY POISONED individuals may exhibit remarkable tolerance to
atropine; two or more times the dosages suggested above may be needed.
Administer PRALIDOXIME (Protopam (TM)-Ayerst, 2-PAM) in cases of severe
poisoning in which respiratory depression, muscle weakness and
twitchings are severe.
Adult dosage: 1.0 gm intravenously at no more than 0.5 gm per minute.
Child's dose (under 12 years): 20-50 mg/kg (depending on severity of
poisoning) intravenously, injecting no more than half the total dose
Dosage of pralidoxime may be repeated in 1-2 hours, then at 10-12 hour
intervals if needed. In very severe poisonings, dosage rates may be
VI. FIRE AND EXPLOSION INFORMATION
Temperatures above 150 C (300 F) cause decomposition with
formation of flammable ethylene gas. Contact with strong oxidizers may
cause fires and explosions. Toxic gases and vapors (such as phosphoric
acid mist and carbon monoxide) may be released when TEPP decomposes
Incompatible with alkaline materials and many pesticides (1).
Corrosive to aluminum (8a).
VIII. PROTECTIVE MEASURES
PROTECTIVE CLOTHING: Employees should be provided with and required
to use impervious clothing, gloves, face shields (eight-inch minimum)
and other appropriate protective clothing necessary to prevent any
possibility of skin contact with TEPP (14).
PROTECTIVE EQUIPMENT: Respirators may be used when engineering and
work practice controls are not technically feasible, when such controls
are in the process of being installed, or when they fail and need to be
supplemented. The only respirators permitted are those that have been
approved by the Mine Safety and Health Administration, or by the
National Institute for Occupational Safety and Health (14).
IX. PROCEDURES FOR SPILLS AND LEAKS
IN CASE OF EMERGENCY, CALL, DAY OR NIGHT
PESTICIDE TEAM SAFETY NETWORK/CHEMTREC
Persons not wearing protective equipment and clothing should be
restricted from areas of spills or leaks until cleanup has been
If TEPP is spilled or leaked, the following steps should be taken:
1. Ventilate area of spill or leak.
2. Collect for reclamation or absorb in vermiculite, dry sand, earth,
or a similar material.
Waste disposal method:
TEPP may be disposed of by absorbing in vermiculite, dry sand,
earth, or a similar material and disposing in sealed containers in a
secured sanitary landfill (14).
X. LITERATURE CITED
1. Harding, W.C. 1979. Pesticide profiles, part one: insecticides
and miticides. Univ. Maryland, Coop. Ext. Serv. Bull. 267.
8a. Thomson, W. T. 1976. Agricultural chemicals - book 1:
insecticides, acaricides, and ovicides. Revised ed. Thomson
Publ., Indianapolis, IN. 232 pp.
14. U. S. Department of Health and Human Services, National Institute
for Occuptational Safety and Health. 1981. Occupational
health guidelines for chemical hazards. F. W. Mackinson, R.
S. Stricoff, L. J. Partridge, Jr., and A. D. Little, Inc.,
eds. DHHS (NIOSH) Publ. No. 81-123. Washington, DC.
15c. American Conference of Governmental Industrial Hygienists. 1984.
TLVs: threshold limit values for chemical substances and
physical agents in the work environment and biological exposure
indices with intended changes for 1984-85. Cincinnati, OH.
25. Morgan, D.P. 1982. Recognition and management of pesticide
poisonings, 3rd ed. U.S. Environmental Protection Agency,
Washington, DC. 120 pp.
56. Farm Chemicals Handbook, 70th ed. 1984. R. T. Meister, G. L.
Berg, C. Sine, S. Meister, and J. Poplyk, eds. Meister
Publishing Co., Willoughby, OH.
62. The Pesticide Manual: A World Compendium, 7th ed. 1983. C.R.
Worthing, ed. The British Crop Protection Council, Croydon,
England. 695 pp.